A Handbook Of Mouse Models Of Cardiovascular Disease
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A Handbook Of Mouse Models Of Cardiovascular Disease
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Author : Qingbo Xu
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-04
A Handbook Of Mouse Models Of Cardiovascular Disease written by Qingbo Xu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-04 with Science categories.
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.
A Handbook Of Mouse Models Of Cardiovascular Disease
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Author : Qingbo Xu
language : en
Publisher:
Release Date : 2006-10-28
A Handbook Of Mouse Models Of Cardiovascular Disease written by Qingbo Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-28 with Science categories.
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook will enable scientists to develop these models in their own laboratories. It contains detailed advice on the issues that investigators need to consider before starting their experiments. It then provides essential information about experimental procedures, specific instruments and technical knowledge and will prove an indispensable guide to all scientists planning to work with these mouse models. This book includes a brief introduction to each disease, followed by a detailed description of the methods and materials used to establish the relevant mouse model. Each chapter has been written by an expert familiar with that system, who provides helpful discussion of the problems that may be encountered and examples of applications of the model. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly. With coverage of all the major mouse models of cardiovascular disease, this book may be used to obtain a broad overview of commonly used methods and, more importantly, as a comprehensive source of detailed information on the development and study of such models. It will prove essential reading to all those working on experimental animal models of cardiovascular disease, from students to independent investigators.
Mouse Models Of Vascular Diseases
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Author : Masataka Sata
language : en
Publisher:
Release Date : 2016
Mouse Models Of Vascular Diseases written by Masataka Sata and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Blood-vessels categories.
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Animal Models In Cardiovascular Research
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Author : D.R. Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Animal Models In Cardiovascular Research written by D.R. Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Animal Models For The Study Of Human Disease
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Author : Li Chen
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by Li Chen and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models, it has been recently recognized that many exciting therapeutic targets identified in small animals are not validated in clinical trials in patients. Thus, suitable large animal models, particularly under conscious state with appropriate direct measurements of cardiovascular function, are needed to serve as a better translational bridge between preclinical and clinical studies. In this chapter, we primarily focus on surgically instrumented large animal models of common cardiovascular disease studied in the conscious state. In addition, several important physiological factors that influence the characteristics of the models, as well as the importance of proper data interpretation, will also be discussed.
Vascular Disease And Injury
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Author : Daniel I. Simon
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-11-09
Vascular Disease And Injury written by Daniel I. Simon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-09 with Medical categories.
A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.
Cardiovascular Physiology In The Genetically Engineered Mouse
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Author : Brian D. Hoit
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cardiovascular Physiology In The Genetically Engineered Mouse written by Brian D. Hoit and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The enormous advances in molecular biology and genetics coupled with the progress in instrumentation and surgical techniques have produced a voluminous and often bewildering quantity of data. The need for a second edition of Cardiovascular Physiology in the Genetically Engineered Mouse is underscored not only by these rapid advances, but by the increasing numbers of scientists who have focussed their research on genetically engineered mice. It is the primary objective of this second edition to interpret critically the literature and to provide a framework for the enormous amount of information in this burgeoning field. As in the first edition, the monograph serves as a practical guide for the investigator interested in the functional methods used to characterize the murine cardiovascular phenotype. However, this guidebook is a more comprehensive text than its predecessor; although the major objectives enumerated in the first edition have not substantially changed, they have been refined in keeping with the increased sophistication of the molecular biologist, geneticist, and physiologist in each other's discipline. Each chapter has been expanded and updated, richly enhanced with original tables and figures, and in many cases, extensively rewritten. Eight chapters written by internationally recognized experts have been added; this represents a 43 % increase from the first edition.
Animal Models In Cardiovascular Research
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Author : David Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-26
Animal Models In Cardiovascular Research written by David Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-26 with Science categories.
Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.
Animal Models For The Study Of Human Disease
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Author : Ross A. Breckenridge
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by Ross A. Breckenridge and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
Myocardial disease is one of the largest medical burdens facing populations of the developed world. Increasing diabetes and obesity in both the developed and developing world suggests that this problem will increase with time. So far, development of novel therapeutic approaches to myocardial disease has lagged behind medical need. One of the key components lacking from this area of medicine is reliable animal systems to model increasingly complex patient populations. This chapter takes a disease-centred approach to reviewing commonly used animal models of myocardial disease. It goes on to discuss possible future approaches to adapting existing models to the changing spectrum of cardiac disease.
Handbook Of Models For Human Aging
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Author : P. Michael Conn
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Handbook Of Models For Human Aging written by P. Michael Conn and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations
