Animal Models Of Human Cognitive Aging
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Animal Models Of Human Cognitive Aging
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Author : Jennifer L. Bizon
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-12
Animal Models Of Human Cognitive Aging written by Jennifer L. Bizon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-12 with Medical categories.
Significant improvements in lifestyle and medical science are leading to an ever increasing elderly population in the United States and other developed nations. The U.S census bureau estimates that the number of people over 65 will nearly double by 2030, and that the elderly will comprise nearly one-fifth of the world’s entire population within the next 20 years. In Animal Models of Human Cognitive Aging, Jennifer Bizon, Alisa Woods, and a panel of international authorities comprehensively discuss the use of animal models as a tool for understanding cognitive changes associated with the aging process. The book provides substantive background on the newest and most widely used animal models in studies of cognition and aging, while detailing the normal and pathological processes of brain aging of humans in relation to those models. Additional chapters comprehensively review frontal cortical deficits and executive function in primates as related to humans, and the use of transgenic modulation in mice to model Alzheimer’s and other age-related diseases. Groundbreaking and authoritative, Animal Models of Human Cognitive Aging provides a valuable resource for Neuroscientists, Gerontological Scientists and all aging medicine researchers, while serving as a primer for understanding current brain aging studies.
Brain Aging
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Author : David R. Riddle
language : en
Publisher: CRC Press
Release Date : 2019-12-16
Brain Aging written by David R. Riddle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-16 with categories.
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur, new possibilities emerge for limiting the effects of aging on neural function. A single source reference is necessary to keep abreast of the recent advances and future directions of gerontology research. Brain Aging: Models, Methods, and Mechanisms offers a selective overview of the research in this rapidly expanding field. A valuable resource for new and established investigators of the aging brain, this volume reviews critical studies of brain aging in new animal models, as well as advances in brain imaging techniques that permit investigations in aging humans with increasingly higher resolution. Detailed discussions link the information from human and animal studies to illustrate a comprehensive picture of the mechanism of aging. Emphasizing normal brain aging rather than pathological degeneration, the text provides an understanding of fundamental age-related changes in the nervous system and hypothesis-driven research into their basis. The book includes critical analyses of the distinct methodological challenges inherent in investigating the aging nervous system. Contributions from distinguished leaders and pioneers in their respective fields address data and mechanisms, as well as models and methods that are key to the study of aging. Each chapter is extensively referenced and highlights experimental concerns that are magnified or unique to the aging brain. Outlining relevant methods and techniques, this book provides scientists, researchers, and clinicians with a broad understanding of the important progress and implications for the future of this significant field.
Behavioral Neurobiology Of Aging
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Author : Marie-Christine Pardon
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-15
Behavioral Neurobiology Of Aging written by Marie-Christine Pardon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-15 with Medical categories.
This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.
Animal Models Of Cognitive Aging And Dementia In The Rat Problems And Perspectives
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Author : Arjan Blokland
language : en
Publisher:
Release Date : 1992
Animal Models Of Cognitive Aging And Dementia In The Rat Problems And Perspectives written by Arjan Blokland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Animal experimentation categories.
Handbook Of Models For Human Aging
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Author : P. Michael Conn
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Handbook Of Models For Human Aging written by P. Michael Conn and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations
Human And Animal Models For Translational Research On Neurodegeneration Challenges And Opportunities From South America
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Author : Agustín Ibáñez
language : en
Publisher: Frontiers Media SA
Release Date : 2018-06-21
Human And Animal Models For Translational Research On Neurodegeneration Challenges And Opportunities From South America written by Agustín Ibáñez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-21 with categories.
Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.
Behavioral Neurobiology Of Aging
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Author : Marie-Christine Pardon
language : en
Publisher: Springer
Release Date : 2012-04-19
Behavioral Neurobiology Of Aging written by Marie-Christine Pardon and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-19 with Medical categories.
This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.
Animal Models Of Cognitive Impairment
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Author : Edward D. Levin
language : en
Publisher: CRC Press
Release Date : 2006-06-22
Animal Models Of Cognitive Impairment written by Edward D. Levin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-22 with Science categories.
The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.
Handbook Of Cognitive Aging
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Author : Scott M. Hofer
language : en
Publisher: SAGE
Release Date : 2008-03-20
Handbook Of Cognitive Aging written by Scott M. Hofer and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-20 with Psychology categories.
"Provides a unique perspective. I am particularly impressed with the sections on innovative design and methods to investigate cognitive aging and the integrative perspectives. None of the existing texts covers this material to the same level." —Donna J. La Voie, Saint Louis University "The emphasis on integrating the literature with theoretical and methodological innovations could have a far-reaching impact on the field." —Deb McGinnis, Oakland University The Handbook of Cognitive Aging: Interdisciplinary Perspectives clarifies the differences in patterns and processes of cognitive aging. Along with a comprehensive review of current research, editors Scott M. Hofer and Duane F. Alwin provide a solid foundation for building a multidisciplinary agenda that will stimulate further rigorous research into these complex factors. Key Features Gathers the widest possible range of perspectives by including cognitive aging experts in various disciplines while maintaining a degree of unity across chapters Examines the limitations of the extant literature, particularly in research design and measurement, and offers new suggestions to guide future research Highlights the broad scope of the field with topics ranging from demography to development to neuroscience, offering the most complete coverage available on cognitive aging
Handbook Of The Neuroscience Of Aging
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Author : Patrick R. Hof
language : en
Publisher: Academic Press
Release Date : 2010-05-22
Handbook Of The Neuroscience Of Aging written by Patrick R. Hof and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-22 with Medical categories.
A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers. This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology. * The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention * Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves * Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries) * Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions * Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.) * Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers * Heavily illustrated with over 100 color figures