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Anti Vegf


Anti Vegf
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Anti Vegf


Anti Vegf
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Author : Francesco Bandello
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-01-01

Anti Vegf written by Francesco Bandello and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with Medical categories.


The development of therapy with anti-angiogenics or vascular endothelial growth factor inhibitors (anti-VEGF) has marked the beginning of a new era in neovascularization and macular edema treatment. Its main goals are the inhibition of growth and development of new vessels along with the reduction of vascular permeability. The advantages over conventional laser photocoagulation are evident as laser treatment always leaves scars and causes a retinal sensitivity deterioration. Starting with an outline of treatment principles, this volume covers all aspects of anti-VEGF therapy for ophthalmological disorders. In particular, specific chapters are dedicated to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory diseases, hereditary dystrophies, retinal vein occlusion, diabetic retinopathy, ocular tumors, as well as anterior segment neovascularization. The book gives an update on the application of anti-VEGF in ocular diseases to general ophthalmologists as well as retina specialists.



Anti Vegf Use In Ophthalmology


Anti Vegf Use In Ophthalmology
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Author : Jay Duker
language : en
Publisher: CRC Press
Release Date : 2024-06-01

Anti Vegf Use In Ophthalmology written by Jay Duker and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-01 with Medical categories.


The introduction of anti-vascular endothelial growth factor (VEGF) agents has revolutionized therapy for a host of ocular diseases associated with leakage from normal blood vessels and pathologic blood vessel growth. Anti-VEGF Use in Ophthalmology is an all-inclusive reference designed to provide detailed, up-to-date, and clinically relevant information on the current use of anti-VEGF agents in the treatment of all ocular conditions. Drs. Jay S. Duker and Michelle C. Liang have assembled a prestigious group of contributors who pool their collective expertise in this comprehensive book. Anti-VEGF Use in Ophthalmology is split into two sections with the first providing the history of VEGF and an overview of anti-VEGF agents and different routes of drug delivery, as it is important for eye care providers to be familiar with up-to-date aspects of the medications and indications for use. The second section details the clinical uses of anti-VEGF agents in numerous ocular diseases, from the anterior segment including cornea and glaucoma to uveitis and various retinal and choroidal diseases. Each chapter in this section summarizes the disease process and utilizes high-quality ocular imaging to demonstrate the therapeutic use of the anti-VEGF agents. Some of the topics covered in Anti-VEGF Use in Ophthalmology: Neovascular Age-Related Macular Degeneration Proliferative Diabetic Retinopathy Retinal Vein Occlusion Uveitis Neovascular Glaucoma Macular Edema Retinopathy of Prematurity Corneal Disease Anti-VEGF Use in Ophthalmology combines the theory and applications of anti-VEGF agents, making it not only a great learning tool for beginners but also a useful reference tool for a wide range of eye care professionals including optometrists, residents, comprehensive ophthalmologists, as well as specialists in anterior segment, pediatrics, and vitreoretinal disease.



Anti Vegf Use In Ophthalmology


Anti Vegf Use In Ophthalmology
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Author : Jay S. Duker
language : en
Publisher: Slack
Release Date : 2017

Anti Vegf Use In Ophthalmology written by Jay S. Duker and has been published by Slack this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Therapeutics, Ophthalmological categories.


The introduction of anti-vascular endothelial growth factor (VEGF) agents has revolutionized therapy for a host of ocular diseases associated with leakage from normal blood vessels and pathologic blood vessel growth. Anti-VEGF Use in Ophthalmology is an all-inclusive reference designed to provide detailed, up-to-date, and clinically relevant information on the current use of anti-VEGF agents in the treatment of all ocular conditions. Drs. Jay S. Duker and Michelle C. Liang have assembled a prestigious group of contributors who pool their collective expertise in this comprehensive book. Anti-VEGF Use in Ophthalmology is split into two sections with the first providing the history of VEGF and an overview of anti-VEGF agents and different routes of drug delivery, as it is important for eye care providers to be familiar with up-to-date aspects of the medications and indications for use. The second section details the clinical uses of anti-VEGF agents in numerous ocular diseases, from the anterior segment including cornea and glaucoma to uveitis and various retinal and choroidal diseases. Each chapter in this section summarizes the disease process and utilizes high-quality ocular imaging to demonstrate the therapeutic use of the anti-VEGF agents. Some of the topics covered in Anti-VEGF Use in Ophthalmology: Neovascular Age-Related Macular Degeneration Proliferative Diabetic Retinopathy Retinal Vein Occlusion Uveitis Neovascular Glaucoma Macular Edema Retinopathy of Prematurity Corneal Disease Anti-VEGF Use in Ophthalmology combines the theory and applications of anti-VEGF agents, making it not only a great learning tool for beginners but also a useful reference tool for a wide range of eye care professionals including optometrists, residents, comprehensive ophthalmologists, as well as specialists in anterior segment, pediatrics, and vitreoretinal disease.



Overview Of Anti Vegf Therapy And Angiogenesis


Overview Of Anti Vegf Therapy And Angiogenesis
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Author :
language : en
Publisher:
Release Date : 2006

Overview Of Anti Vegf Therapy And Angiogenesis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.




Vegf Mediated Vascular Functions In Health And Disease


Vegf Mediated Vascular Functions In Health And Disease
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Author : Ziquan Cao
language : en
Publisher: Linköping University Electronic Press
Release Date : 2015-04-24

Vegf Mediated Vascular Functions In Health And Disease written by Ziquan Cao and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-24 with Diseases categories.


Angiogenesis is essential for physiological processes including embryonic development, tissue regeneration, and reproduction. Under various pathological conditions the same angiogenic process contribute to the onset, development, and progression of many human diseases including cancer, diabetic complications, ocular disease, chronic inflammation and cardiovascular disease. Vascular endothelial growth factor (VEGF) is a key angiogenic factor for physiological and pathological angiogenesis. In addition to its strong angiogenic activity, VEGF also potently induces vascular permeability, often causing tissue edema in various pathological tissues. VEGF transduces its vascular signal through two tyrosine kinase receptors-VEGFR1 and VEGFR2, the latter being a functional receptor that mediates both angiogenic and vascular permeability effects. To study physiological and pathological functions of VEGF, we developed novel zebrafish disease models that permit us to study hypoxia-induced retinopathy and cancer metastasis processes. We have also administered anti-VEGF and anti-VEGFR specific antibodies to healthy mice to study the homeostatic role of VEGF in the maintenance of vascular integrity and its functions in various tissues and organs. Finally, using a zebrafish model, we evaluated if VEGF expression is regulated by circadian clock genes. In paper I, we developed protocols that create hypoxia-induced retinopathy in adult zebrafish. Adult fli1:EGFP zebrafish were placed in hypoxic water for 3-10 days with retinal neovascularization being analyzed using confocal microscopy. This model provides a unique opportunity to kinetically study the development of retinopathy in adult animals using non-invasive protocols and to assess the therapeutic efficacy of orally administered anti-angiogenic drugs. In paper II, we developed a zebrafish metastasis model to dissect the complex events of hypoxia-induced tumor cell invasion and metastasis in association with angiogenesis at the single-cell level. In this model, fluorescent DiI-labeled human or mouse tumor cells were implanted into the perivitelline cavity of 48-hour-old zebrafish embryos, which were subsequently placed in hypoxic water for 3 days. Tumor cell invasion, metastasis and pathological angiogenesis were analyzed using fluorescent microscopy in the living fish. The average experimental time for this model is 7 days. Our protocol offers an opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis. In paper III, we show that systemic delivery of an anti-VEGF or an anti-VEGF receptor (VEGFR)-2 neutralizing antibody cause global vascular regression in mice. Among all examined tissues, the vasculature in endocrine glands, intestinal villi, and the uterus are most affected in response to VEGF or VEGFR-2 blockades. Pro-longed anti-VEGF treatment resulted in a significant decrease in the circulating levels of the predominant thyroid hormone, free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid function. These findings provide structural and functional bases of anti-VEGF-specific druginduced side effects in relation to vascular changes in healthy tissues. In paper IV, we show that disruption of the circadian clock by constant exposure to light coupled with genetic manipulation of key genes in the zebrafish led to impaired developmental angiogenesis. A bmal1-specific morpholino inhibited developmental angiogenesis in zebrafish embryos without causing obvious nonvascular phenotypes. Conversely, a period2 morpholino accelerated angiogenic vessel growth, suggesting that Bmal1 and Period2 display opposing angiogenic effects. These results offer mechanistic insights into the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis. Overall, the results in this thesis provide further insight to angiogenic mechanistic properties in tissues and suggest possible novel therapeutic targets for the treatment of various angiogenesis-dependent diseases.



Therapeutic Antibodies


Therapeutic Antibodies
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Author : Yuti Chernajovsky
language : en
Publisher: Springer
Release Date : 2007-11-22

Therapeutic Antibodies written by Yuti Chernajovsky and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-22 with Medical categories.


This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.



Anti Vegf Agents For Age Related Macular Degeneration


Anti Vegf Agents For Age Related Macular Degeneration
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Author : Shani Golan
language : en
Publisher:
Release Date : 2013

Anti Vegf Agents For Age Related Macular Degeneration written by Shani Golan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medicine categories.


Anti VEGF Agents for Age Related Macular Degeneration.



Anti Vegf Monotherapy As Treatment Of Wet Age Related Macular Degeneration


Anti Vegf Monotherapy As Treatment Of Wet Age Related Macular Degeneration
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Author : Dharti Joshi
language : en
Publisher:
Release Date : 2014

Anti Vegf Monotherapy As Treatment Of Wet Age Related Macular Degeneration written by Dharti Joshi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Blood-vessels categories.


Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over the age of 50 in the developed world. Although majority of individual's suffering from the condition have the dry form of the condition, it is the wet AMD that results in detrimental vision loss. This past decade has seen a great advancement in treatment of wet AMD through use of anti-angiogenic therapy in the form of anti-vascular endothelial growth factors (anti-VEGF) agents. In addition to halting the damage caused by angiogenic factors, anti-VEGF therapy also aims at preventing vision loss thus, making it a primary choice of physicians in treatment of wet AMD. This review aims at presenting a comprehensive summery of all of the currently available anti-VEGF drugs including their safety, efficacy and appropriate modality of treatment.



Anti Vegf Therapy In Ophthalmology


Anti Vegf Therapy In Ophthalmology
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Author : Evan S. Caplan
language : en
Publisher:
Release Date : 2016

Anti Vegf Therapy In Ophthalmology written by Evan S. Caplan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.




Vegf Vegfr Inhibitors Advances In Research And Application 2013 Edition


Vegf Vegfr Inhibitors Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21

Vegf Vegfr Inhibitors Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.


VEGF - VEGFR Inhibitors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Sorafenib in a concise format. The editors have built VEGF - VEGFR Inhibitors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Sorafenib in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of VEGF - VEGFR Inhibitors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.