Anti Vegf Monotherapy As Treatment Of Wet Age Related Macular Degeneration
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Anti Vegf Monotherapy As Treatment Of Wet Age Related Macular Degeneration
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Author : Dharti Joshi
language : en
Publisher:
Release Date : 2014
Anti Vegf Monotherapy As Treatment Of Wet Age Related Macular Degeneration written by Dharti Joshi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Blood-vessels categories.
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over the age of 50 in the developed world. Although majority of individual's suffering from the condition have the dry form of the condition, it is the wet AMD that results in detrimental vision loss. This past decade has seen a great advancement in treatment of wet AMD through use of anti-angiogenic therapy in the form of anti-vascular endothelial growth factors (anti-VEGF) agents. In addition to halting the damage caused by angiogenic factors, anti-VEGF therapy also aims at preventing vision loss thus, making it a primary choice of physicians in treatment of wet AMD. This review aims at presenting a comprehensive summery of all of the currently available anti-VEGF drugs including their safety, efficacy and appropriate modality of treatment.
Age Related Macular Degeneration
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Author : Gui-Shuang Ying
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-20
Age Related Macular Degeneration written by Gui-Shuang Ying and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-20 with Medical categories.
Age-related Macular Degeneration (AMD) is the leading cause of vision loss and blindness in the developed countries. In the past decade, great progress has been made in understanding the pathobiology and genetics of this blinding disease, as well as in finding new therapies for its treatment. These include the discovery of several genes that are associated with the risk of AMD, new anti-VEGF treatments for wet AMD and new imaging techniques to diagnose and monitor the AMD. All chapters in this book were contributed by outstanding research scientists and clinicians in the area of AMD. I hope this timely book will provide the basic scientists and clinicians with an opportunity to learn about the recent advances in the field of AMD.
Anti Vegf
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Author : Francesco Bandello
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-01-01
Anti Vegf written by Francesco Bandello and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with Medical categories.
The development of therapy with anti-angiogenics or vascular endothelial growth factor inhibitors (anti-VEGF) has marked the beginning of a new era in neovascularization and macular edema treatment. Its main goals are the inhibition of growth and development of new vessels along with the reduction of vascular permeability. The advantages over conventional laser photocoagulation are evident as laser treatment always leaves scars and causes a retinal sensitivity deterioration. Starting with an outline of treatment principles, this volume covers all aspects of anti-VEGF therapy for ophthalmological disorders. In particular, specific chapters are dedicated to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory diseases, hereditary dystrophies, retinal vein occlusion, diabetic retinopathy, ocular tumors, as well as anterior segment neovascularization. The book gives an update on the application of anti-VEGF in ocular diseases to general ophthalmologists as well as retina specialists.
Sustained Delivery Of Anti Vegf For Treating Wet Age Related Macular Degeneration
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Author : Pengfei Jiang
language : en
Publisher:
Release Date : 2020
Sustained Delivery Of Anti Vegf For Treating Wet Age Related Macular Degeneration written by Pengfei Jiang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Blood-vessels categories.
To halt the progression of AMD, the monthly intravitreal injection of anti-VEGF is the current gold standard treatment, which relies on deactivating free VEGF in the eye. However, frequent invasive injections are associated with potential complications and low patient compliance. Previous research has focused on developing micro-sized and nano-sized drug delivery devices composed of poly(lactic-co-glycolic acid) (PLGA) or polydimethylsiloxane (PDMS). Unfortunately, the aforementioned devices could not release protein therapeutics sustainably and were limited by the release duration of four months, which reduces potential treatment efficacy.
Sustained Release Of Anti Vegf From Injectable Devices For Treating Wet Age Related Macular Degeneration
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Author : Pengfei Jiang
language : en
Publisher:
Release Date : 2018
Sustained Release Of Anti Vegf From Injectable Devices For Treating Wet Age Related Macular Degeneration written by Pengfei Jiang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Chemical engineering categories.
Age-related macular degeneration (AMD) is the fourth most common cause of blindness in the world. There are more than 11 million people diagnosed with AMD in the United States. It is estimated that this number will double in 2050. Accordingly, much work has been done understanding disease pathogenesis and developing therapeutic methods. It is widely noted that overexpression of vascular endothelial growth factor (VEGF) along with aging stimulates neovascularization in the choroid, which leads to irreversible damages to the retina during bleeding and scarring of newly formed blood vessels. The current gold standard treatment for wet AMD is a monthly intravitreal injection of anti-VEGF such as bevacizumab or ranibizumab to inhibit VEGF and to prevent angiogenesis. However, frequent injections often lead to infection, elevated intraocular pressure and rhegmatogenous retinal detachment, as well as issues with patient compliance. Therefore, there is a need for an improved therapeutic approach for the treatment of wet AMD. To address the problems associated with the current clinical treatment, we have developed several novel devices made from two polymeric materials to extend the period of drug release and to avoid the side effects associated with the monthly anti-VEGF injection. Our novel devices are in two different forms, microparticle and capsule. The preliminary results demonstrate that the devices enable the longer-term local drug administration as compared to previously reported devices. This study provides an alternative method to raise the therapeutic efficacy and further improve the quality of life for people diagnosed with wet AMD.
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration
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Author : Maja Vinković
language : en
Publisher:
Release Date : 2019
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration written by Maja Vinković and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Age-related macular degeneration (AMD) is one of the most common causes of severe visual loss in middle and old-age population, and often leads to serious deterioration in quality of life. Currently, the first-line treatment for neovascular AMD (nAMD) are intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications, including bevacizumab, ranibizumab, and aflibercept and also latest commercially available drug, brolucizumab. During initial examination and imaging and treatment follow-up for patients with nAMD, optical coherence tomography (OCT) is used to predict and assess the therapeutic response and guide the treatment. Several OCT-based biomarkers, including the central subfoveal thickness (CSFT), the presence of intraretinal cysts (IRCs) or subretinal fluid (SRF), and the presence of pigment epithelial detachment (PED), were found to influence baseline visual acuity or visual improvements. Recent analyses of large randomized control trials (RCTs) summarized the usefulness of these OCT-based biomarkers. However, many of these early studies relied on time-domain OCT to evaluate the retinal structures thus providing less precise evaluation of the retinal details. After introduction of spectral-domain OCT (SD-OCT) which provided high resolution images, recent studies offered new insights in specific morphological changes and their different impact on visual function in nAMD. For example, these advancement in resolution offered new classification of IRCs into degenerative and exudative which impacts treatment strategy and final outcome in the treatment of nAMD. Moreover, the recent data disclose a substantial difference between RCTs and real-world studies regarding the response to anti-VEGF therapy. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a realworld setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy. These observations mandate large longitudinal studies focusing on the usefulness of these high resolution SD-OCT biomarkers in real-world situations.
Treatment Of Wet Age Related Macular Degeneration
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Author : Krista Henry
language : en
Publisher:
Release Date : 2014
Treatment Of Wet Age Related Macular Degeneration written by Krista Henry and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Blood-vessels categories.
In optometric practice, age related macular degeneration (AMD) is a disease commonly seen in patients over the age of 65. As this disease can cause devastating effects on vision it is important to identify as well as treat and manage AMD with the most effective methods. Once AMD has progressed from the dry o wet form, intravitreal anti-VEGF injections are given to ameliorate vision and prevent the progression of the disease. The three anti-VEGF injections and how Lucentis, Avastin and Macugen. This literature review discusses these three injections and how Lucentis and Avastin are the most effective lines of treatment. Both of these anti-VEGF injections ameliorate visual acuity after being administered for a year.
New Therapies In The Treatment And Management Of Age Related Macular Degeneration
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Author : Gina Buk
language : en
Publisher:
Release Date : 2019
New Therapies In The Treatment And Management Of Age Related Macular Degeneration written by Gina Buk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Eye categories.
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in the developed countries. AMD is divided into two forms, dry and wet, referring to the absence or presence of neovascularization. There is currently no cure for either form and the current treatment for AMD on the market involves monthly intravitreal injections of anti-VEGF therapy. However, researchers are studying new treatments to either revert and/or prevent further vision loss with greater efficacy ad potency. In this review, we examined some of the therapeutic applications in AMD treatment that could change the visual outcome and improve the quality of life for patients with AMD.
Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration
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Author : Farshad Abedi
language : en
Publisher:
Release Date : 2013
Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration written by Farshad Abedi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Bevacizumab categories.
Macular Disorders
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Author : Ivana K. Kim
language : en
Publisher: Springer Nature
Release Date : 2020-05-27
Macular Disorders written by Ivana K. Kim and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-27 with Medical categories.
This atlas presents chapters on common and rare macular diseases including variants of age-related macular degeneration (dry, neovascular, polypoidal choroidal vasculopathy), cystoid macular edema, macular telangiectasia, central serous retinopathy and pachychoroid disease, photic retinopathy, presumed ocular histoplasmosis syndrome, myopic degeneration, angioid streaks, and a recently described entity: perifoveal exudative vascular anomalous complex. It provides a wealth of representative images, using various modalities to help the reader recognize the respective conditions. Importantly, it also includes images acquired using techniques more recently adopted in clinical practice such as autofluoresence, optical coherence tomography (OCT), and OCT angiography. The concise text reviews the basic concepts of etiology, diagnosis, and management in a highly accessible format. In contributions prepared by internationally respected experts, the atlas provides a cutting-edge analysis of each condition, as well as excellent summaries of recent work in the field. Macular Disorders is one of nine volumes in the series Retina Atlas. The series offers a global perspective on vitreoretinal diseases, covering imaging basics, retinal vascular disease, ocular inflammatory disease, retinal degeneration, surgical retina, macular disorders, ocular oncology, pediatric retina and trauma. In nine volumes and over 100 chapters, Retina Atlas offers comprehensive and validated information on retinal disorders.