Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration
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Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration
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Author : Maja Vinković
language : en
Publisher:
Release Date : 2019
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration written by Maja Vinković and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Age-related macular degeneration (AMD) is one of the most common causes of severe visual loss in middle and old-age population, and often leads to serious deterioration in quality of life. Currently, the first-line treatment for neovascular AMD (nAMD) are intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications, including bevacizumab, ranibizumab, and aflibercept and also latest commercially available drug, brolucizumab. During initial examination and imaging and treatment follow-up for patients with nAMD, optical coherence tomography (OCT) is used to predict and assess the therapeutic response and guide the treatment. Several OCT-based biomarkers, including the central subfoveal thickness (CSFT), the presence of intraretinal cysts (IRCs) or subretinal fluid (SRF), and the presence of pigment epithelial detachment (PED), were found to influence baseline visual acuity or visual improvements. Recent analyses of large randomized control trials (RCTs) summarized the usefulness of these OCT-based biomarkers. However, many of these early studies relied on time-domain OCT to evaluate the retinal structures thus providing less precise evaluation of the retinal details. After introduction of spectral-domain OCT (SD-OCT) which provided high resolution images, recent studies offered new insights in specific morphological changes and their different impact on visual function in nAMD. For example, these advancement in resolution offered new classification of IRCs into degenerative and exudative which impacts treatment strategy and final outcome in the treatment of nAMD. Moreover, the recent data disclose a substantial difference between RCTs and real-world studies regarding the response to anti-VEGF therapy. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a realworld setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy. These observations mandate large longitudinal studies focusing on the usefulness of these high resolution SD-OCT biomarkers in real-world situations.
Anti Vegf
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Author : Francesco Bandello
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-01-01
Anti Vegf written by Francesco Bandello and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with Medical categories.
The development of therapy with anti-angiogenics or vascular endothelial growth factor inhibitors (anti-VEGF) has marked the beginning of a new era in neovascularization and macular edema treatment. Its main goals are the inhibition of growth and development of new vessels along with the reduction of vascular permeability. The advantages over conventional laser photocoagulation are evident as laser treatment always leaves scars and causes a retinal sensitivity deterioration. Starting with an outline of treatment principles, this volume covers all aspects of anti-VEGF therapy for ophthalmological disorders. In particular, specific chapters are dedicated to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory diseases, hereditary dystrophies, retinal vein occlusion, diabetic retinopathy, ocular tumors, as well as anterior segment neovascularization. The book gives an update on the application of anti-VEGF in ocular diseases to general ophthalmologists as well as retina specialists.
Age Related Macular Degeneration
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Author : D. Virgil Alfaro
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2006
Age Related Macular Degeneration written by D. Virgil Alfaro and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
A renowned group of retina surgeons presents promising new developments in age-related macular degeneration, with emphasis on the most significant advances in the past five years. Content addresses all aspects of management, including anatomy, physiology, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and treatment; treatment; and future directions. Abundantly illustrated and superbly organized, this book serves as an excellent reference and textbook.
Recent Advances And New Perspectives In Managing Macular Degeneration
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Author : Pinakin Gunvant Davey
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-09-28
Recent Advances And New Perspectives In Managing Macular Degeneration written by Pinakin Gunvant Davey and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-28 with Medical categories.
Macular degeneration is a blinding disease with huge socioeconomic costs. This book presents a comprehensive overview of macular degeneration, including age-related macular degeneration (AMD). Chapters address such topics as the disease state of macular degeneration, diagnosis and management of AMD, treatment considerations, and vision rehabilitation. It is a useful resource for both novice readers and experts in the field.
Age Related Macular Degeneration
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Author : Gui-Shuang Ying
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-20
Age Related Macular Degeneration written by Gui-Shuang Ying and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-20 with Medical categories.
Age-related Macular Degeneration (AMD) is the leading cause of vision loss and blindness in the developed countries. In the past decade, great progress has been made in understanding the pathobiology and genetics of this blinding disease, as well as in finding new therapies for its treatment. These include the discovery of several genes that are associated with the risk of AMD, new anti-VEGF treatments for wet AMD and new imaging techniques to diagnose and monitor the AMD. All chapters in this book were contributed by outstanding research scientists and clinicians in the area of AMD. I hope this timely book will provide the basic scientists and clinicians with an opportunity to learn about the recent advances in the field of AMD.
Age Related Macular Degeneration
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Author : Jay Duker
language : en
Publisher: CRC Press
Release Date : 2024-06-01
Age Related Macular Degeneration written by Jay Duker and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-01 with Medical categories.
Retinal disease in general, and age-related macular degeneration (AMD) specifically, is of major interest worldwide due to the increasing aging population and the revolution in management of wet AMD over the past several years. Age-Related Macular Degeneration presents an up-to-date, clinically relevant monograph on the current diagnosis and management of AMD. Age-Related Macular Degeneration by Drs. Jay S. Duker and Andre J. Witkin serves as a reference for ophthalmologists treating AMD in the clinic as well as other eye care professionals who see and counsel patients with AMD. Chapters will focus on the pathogenesis and risk factors for AMD, the diagnosis of AMD, treatment options, and promising investigative interventions. To help readers gain familiarity recognizing AMD, the book contains multiple images in different formats: high quality color fundus photographs, black-and-white angiograms, black-and-white autofluorence images, and both color and black-and-white OCT images. Relevant to current management of AMD, Age-Related Macular Degeneration: Current Management concentrates on “clinical utility” rather than emphasizing published studies, filling the current void in the market for the general ophthalmology and optometry audience. Comprehensive ophthalmologists, optometrists and retinal specialists will appreciate the book’s practical approach to AMD.
Age Related Macular Degeneration
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Author : Weiye Li
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-03-23
Age Related Macular Degeneration written by Weiye Li and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-23 with Medical categories.
A consolidated view of a complex disorder, Age-Related Macular Degeneration, summarizes the latest evidence-based studies and translates these advancements into practical, actionable knowledge. This concise resource covers the fundamentals of age-related macular degeneration (AMD) diagnosis and treatment along with a modern definition of the disorder that acknowledges the range of presentations that ophthalmologists see in real practice. Offering practical, clinical guidance in addition to capturing new therapeutic approaches in the pipeline, this book is an essential reference for ophthalmologists, optometrists, and researchers. Takes a concise, yet comprehensive, approach to AMD, covering both basic science and clinical guidance. Features clinical guidelines on the diagnosis and treatment of AMD, including classification, signs/symptoms, imaging, and differential diagnosis in the pre-optical coherence tomography (OCT) and modern OCT eras. Presents up-to-date information on AMD therapies currently in the development pipeline and offers insights for the future of translational research. Explains molecular genetics and pathogenic events of AMD from both basic and clinical perspectives, which may help readers seek promising new therapeutic targets Contains more than 250 images, with multimodal imaging techniques that clearly demonstrate AMD pathophysiology and clinical pathology.
Age Related Macular Degeneration
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Author : Christopher Schütze
language : en
Publisher: epubli
Release Date : 2019-02-03
Age Related Macular Degeneration written by Christopher Schütze and has been published by epubli this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-03 with Medical categories.
Age-related macular degeneration (AMD) is a chronic disease leading to severe visual deterioration and impairment of daily life. Two types of AMD are distinguished: Wet or neovascular AMD and dry AMD. Dry AMD is characterized by drusen (small yellowish retinal deposits) and atrophy of the retinal pigment epithelium (RPE); causal treatment is currently not available. Wet AMD is marked by abnormal growth of blood vessels within the macular area (spot of sharpest sight) leading to fluid accumulation (edema) and retinal bleeding as well as scar formation. If the disease is not treated severe irreversible visual impairment will result. Treatment with new agents that are administered intravitreally and act against vascular endothelial growth factor (VEGF) are now available, impeding disease progression in many cases. The present book gives a comprehensive overview about all aspects of AMD, useful for affected patients and interested readers and covers causes, epidemiological facts, diagnostics (emphasizing the topic optical coherence tomography-OCT) and treatment strategies of the disease, based on extensive literature research.
Oct Biomarkers For Amd
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Author : Luciana de S√° Quirino-Makarczyk
language : en
Publisher:
Release Date : 2020
Oct Biomarkers For Amd written by Luciana de S√° Quirino-Makarczyk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Electronic books categories.
Age-related Macular Degeneration (AMD) is an acquired retina disease that can potentially cause significant central visual impairment. Optical coherence tomography (OCT) applied to the study of retinal pathologies has revolutionized the understanding and management of AMD, especially with the technology of full-depth imaging (FDI) Spectral Domain (SD) OCT. With the increasing amount of data from several important studies using SD-OCT and OCT-angiography (OCT-A) we can now better classify and more accurately decode AMD. The purpose of this chapter is to describe the most important AMD biomarkers recently discovered using SD OCT. Understanding AMD phenotype is very important to define prognosis and individualized forms of treatment and follow up. Biomarkers on OCT have been crucial for a better understanding of AMD.
Optical Coherence Tomography Monitoring Strategies For A Vegf Treated Age Related Macular Degeneration
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Author : G. Pron
language : en
Publisher:
Release Date : 2014
Optical Coherence Tomography Monitoring Strategies For A Vegf Treated Age Related Macular Degeneration written by G. Pron and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Electronic books categories.