Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration
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Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration
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Author : Farshad Abedi
language : en
Publisher:
Release Date : 2013
Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration written by Farshad Abedi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Bevacizumab categories.
Predictors Of Anti Vascular Endothelial Growth Factor Treatment Response In Neovascular Age Related Macular Degeneration
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Author : Sanjeewa Wickremasinghe
language : en
Publisher:
Release Date : 2015
Predictors Of Anti Vascular Endothelial Growth Factor Treatment Response In Neovascular Age Related Macular Degeneration written by Sanjeewa Wickremasinghe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Retinal degeneration categories.
Prognostic Factors For Long Term Visual Acuity Outcome After Ranibizumab Therapy In Patients With Neovascular Age Related Macular Degeneration
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Author : Steffen Hillebrand
language : de
Publisher:
Release Date : 2015
Prognostic Factors For Long Term Visual Acuity Outcome After Ranibizumab Therapy In Patients With Neovascular Age Related Macular Degeneration written by Steffen Hillebrand and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Management Strategies And Visual Results For The Treatment Of Neovascular Age Related Macular Degeneration
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Author : Sean Adrean
language : en
Publisher:
Release Date : 2022
Management Strategies And Visual Results For The Treatment Of Neovascular Age Related Macular Degeneration written by Sean Adrean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Electronic books categories.
The purpose of this chapter is to examine the various treatment strategies used to manage neovascular age-related macular degeneration (nAMD). The chapter will focus on the three main strategies including fixed interval dosing, as needed Pro-Re-Nata (PRN) treatment and Treat-and-Extend (TAE), with its variant the Treat-Extend-Stop (TES) protocol. We will discuss the visual results of randomized clinical trials and retrospective studies using these methodologies and compare their outcomes, the pros and cons of each treatment strategy, as well as the underlying mechanisms that may explain these differences. The results of long-term extension trials following landmark randomized clinical studies and other long-term retrospective studies will also be compared to studies using a fixed interval dosing or the TAE/TES method. We will also focus on the visual results of the TES protocol and examine recurrence rates, proposing a definition of the recurrence of choroidal neovascularization (CNV) versus increased disease activity. These topics discussed will help optimize anti-VEGF treatment regimens for patients with nAMD over the long term.
Indocyanine Green Angiography
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Author : Lawrence A. Yannuzzi
language : en
Publisher:
Release Date : 1997
Indocyanine Green Angiography written by Lawrence A. Yannuzzi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This is the only text available that is devoted exclusively to the ICG imaging technique, its methods and findings. It provides an invaluable guide to this new diagnostic/research tool.
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration
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Author : Maja Vinković
language : en
Publisher:
Release Date : 2019
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration written by Maja Vinković and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Age-related macular degeneration (AMD) is one of the most common causes of severe visual loss in middle and old-age population, and often leads to serious deterioration in quality of life. Currently, the first-line treatment for neovascular AMD (nAMD) are intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications, including bevacizumab, ranibizumab, and aflibercept and also latest commercially available drug, brolucizumab. During initial examination and imaging and treatment follow-up for patients with nAMD, optical coherence tomography (OCT) is used to predict and assess the therapeutic response and guide the treatment. Several OCT-based biomarkers, including the central subfoveal thickness (CSFT), the presence of intraretinal cysts (IRCs) or subretinal fluid (SRF), and the presence of pigment epithelial detachment (PED), were found to influence baseline visual acuity or visual improvements. Recent analyses of large randomized control trials (RCTs) summarized the usefulness of these OCT-based biomarkers. However, many of these early studies relied on time-domain OCT to evaluate the retinal structures thus providing less precise evaluation of the retinal details. After introduction of spectral-domain OCT (SD-OCT) which provided high resolution images, recent studies offered new insights in specific morphological changes and their different impact on visual function in nAMD. For example, these advancement in resolution offered new classification of IRCs into degenerative and exudative which impacts treatment strategy and final outcome in the treatment of nAMD. Moreover, the recent data disclose a substantial difference between RCTs and real-world studies regarding the response to anti-VEGF therapy. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a realworld setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy. These observations mandate large longitudinal studies focusing on the usefulness of these high resolution SD-OCT biomarkers in real-world situations.
Optical Coherence Tomography Of Ocular Diseases
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Author : Joel S. Schuman
language : en
Publisher: CRC Press
Release Date : 2024-06-01
Optical Coherence Tomography Of Ocular Diseases written by Joel S. Schuman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-01 with Medical categories.
The most comprehensive text and definitive guide for nearly 30 years about optical coherence tomography (OCT) imaging in ophthalmology, Optical Coherence Tomography of Ocular Diseases, Fourth Edition covers a range of subjects, from principles and operation techniques to clinical interpretation and the latest innovations in OCT. Written by the pioneers of OCT technologies and the world-renowned OCT researchers Drs. Joel S. Schuman, James G. Fujimoto, Jay S. Duker, Hiroshi Ishikawa, and Gadi Wollstein, Optical Coherence Tomography of Ocular Diseases, Fourth Edition is an essential text for imaging technology. OCT now occupies a dominant role as a diagnostic tool for retinal conditions and glaucoma. At the same time, the technology continues to show potential for emerging clinical and research applications across all the ophthalmological subspecialties. To reflect these rapid advances, this new edition of Optical Coherence Tomography of Ocular Diseases features a complete and thorough revision of the existing text as well as the addition of cutting-edge content to bring this classic resource completely up to date. New content in the Fourth Edition includes: • OCT angiography • Swept-source OCT • OCT in multimodal imaging • Clinical utility of OCT in glaucoma prediction and progression detection • OCT for neuro-ophthalmology Optical Coherence Tomography of Ocular Diseases, Fourth Edition is the one and only book needed by practitioners who use OCT for clinical eye care.
Diabetic Retinopathy And Cardiovascular Disease
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Author : C. Sabanayagam
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2019-06-03
Diabetic Retinopathy And Cardiovascular Disease written by C. Sabanayagam and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-03 with Medical categories.
Diabetic retinopathy (DR), a common microvascular complication, has consistently been shown to be associated with an increased risk of cardiovascular disease (CVD). This book provides complete coverage of DR as a potential marker for CVD in those with diabetes. It succinctly reviews the epidemiological and pathogenic links of DR to various cardiovascular events including stroke, coronary artery disease, chronic kidney disease, heart failure, and mortality. Furthermore, it discusses the usefulness of DR in CVD risk prediction and cardiovascular safety of anti-VEGF therapy in diabetic patients. There are insights from contemporary diabetic trials that demonstrated the enhanced cardiovascular benefit of novel glucose lowering therapy. It also highlights the potential of novel retinal imaging to predict CVD and its risk factors using the state-of-the art artificial intelligence-based deep learning systems. This book will be an invaluable resource for specialists translating research findings into clinical care, including those in cardiology, endocrinology, ophthalmology, and general practitioners. IT will also be of interest to public health practitioners, researchers, graduate students, and biotech companies interested in developing retinal image-based diagnostic and prognostic tools.
Sample Size Calculations In Clinical Research
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Author : Shein-Chung Chow
language : en
Publisher: CRC Press
Release Date : 2017-08-15
Sample Size Calculations In Clinical Research written by Shein-Chung Chow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-15 with Mathematics categories.
Praise for the Second Edition: "... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.
Management Of Diabetic Retinopathy
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Author : F. Bandello
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2017-04-20
Management Of Diabetic Retinopathy written by F. Bandello and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-20 with Medical categories.
Recently developed diagnostic and therapeutic technologies such as OCT-angiography and small gauge vitrectomy have influenced the modern treatment of diabetic retinopathy. This volume provides a summary of the state-of-the-art evidence-based approach to managing complications that may occur with diabetic retinopathy. It offers the latest information on pathogenesis and diagnosis, and highly experienced clinicians review the results of relevant randomized clinical trials that serve as the basis of current therapy. The book provides not only a summary of data from randomized trials but also an analysis and interpretation by internationally renowned experts. Ophthalmology residents, fellows, and practicing clinicians will find this book to be a useful reference when seeking evidence-based treatment strategies for various complications of diabetic retinopathy. It is also for researchers identifying new avenues of drug developments and for insurance professionals and health care policy administrators who are establishing evidence-based therapy guidelines for therapeutic intervention.