Predictors Of Anti Vascular Endothelial Growth Factor Treatment Response In Neovascular Age Related Macular Degeneration
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Predictors Of Anti Vascular Endothelial Growth Factor Treatment Response In Neovascular Age Related Macular Degeneration
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Author : Sanjeewa Wickremasinghe
language : en
Publisher:
Release Date : 2015
Predictors Of Anti Vascular Endothelial Growth Factor Treatment Response In Neovascular Age Related Macular Degeneration written by Sanjeewa Wickremasinghe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Retinal degeneration categories.
Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration
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Author : Farshad Abedi
language : en
Publisher:
Release Date : 2013
Predictors Of Outcome Of Anti Vegf Treatment In Neovascular Age Related Macular Degeneration written by Farshad Abedi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Bevacizumab categories.
Does The Epiretinal Membrane Influence Anti Vascular Endothelial Growth Factor Response In Neovascular Age Related Macular Degeneration Treatment Anglais
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Author : Florine Reynaud
language : en
Publisher:
Release Date : 2022
Does The Epiretinal Membrane Influence Anti Vascular Endothelial Growth Factor Response In Neovascular Age Related Macular Degeneration Treatment Anglais written by Florine Reynaud and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Évaluer l'influence de la membrane épirétinienne sur l'efficacité des anti-VEGF dans le traitement de la DMLA exsudative. Nous avons rétrospectivement inclus dans l'étude des patients naïfs de tout traitement. Les yeux ont été divisé en 2 groupes selon la présence ou l'absence d'une membrane épirétinienne. L'acuité visuelle (AV), l'épaisseur maculaire centrale (EMC) ainsi que le nombre d'injections ont été relevés lors du diagnostic, à 12 et 24 mois. Des analyses en sous-groupes selon la molécule anti-VEGF reçu ont été réalisées. Un total de 202 yeux de 173 patients a été inclus dans l'étude parmi lesquels 42 yeux porteurs d'une MER comparés à 160 yeux dépourvus de MER. Le gain d'acuité visuelle après 24 mois était significativement plus important chez les patients dépourvus de MER (p=0,01). Parallèlement, le nombre d'injections intravitréennes était également plus élevé chez ces patients (p=0,01). Les analyses en sous-groupes ont révélé, au sein des patients traités par aflibercept, une différence significative en termes de gain d'acuité visuelle (p=0.03), nombre d'injection cumulées (p=0.005) et EMC moyenne à 24 mois (p=0.01); contrairement aux patients sous ranibizumab parmi lesquels la différence entre les 2 groupes fut moins importante et par conséquent non significative. La présence d'une membrane épirétinienne parmi les patients atteints d'une DMLA exsudative pourrait freiner la récupération visuelle et accroitre le nombre d'injections intravitréennes. Cette observation semble être atténuée chez les patients traités par ranibizumab.
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration
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Author : Maja Vinković
language : en
Publisher:
Release Date : 2019
Anti Vegf Treatment And Optical Coherence Tomography Biomarkers In Wet Age Related Macular Degeneration written by Maja Vinković and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Age-related macular degeneration (AMD) is one of the most common causes of severe visual loss in middle and old-age population, and often leads to serious deterioration in quality of life. Currently, the first-line treatment for neovascular AMD (nAMD) are intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications, including bevacizumab, ranibizumab, and aflibercept and also latest commercially available drug, brolucizumab. During initial examination and imaging and treatment follow-up for patients with nAMD, optical coherence tomography (OCT) is used to predict and assess the therapeutic response and guide the treatment. Several OCT-based biomarkers, including the central subfoveal thickness (CSFT), the presence of intraretinal cysts (IRCs) or subretinal fluid (SRF), and the presence of pigment epithelial detachment (PED), were found to influence baseline visual acuity or visual improvements. Recent analyses of large randomized control trials (RCTs) summarized the usefulness of these OCT-based biomarkers. However, many of these early studies relied on time-domain OCT to evaluate the retinal structures thus providing less precise evaluation of the retinal details. After introduction of spectral-domain OCT (SD-OCT) which provided high resolution images, recent studies offered new insights in specific morphological changes and their different impact on visual function in nAMD. For example, these advancement in resolution offered new classification of IRCs into degenerative and exudative which impacts treatment strategy and final outcome in the treatment of nAMD. Moreover, the recent data disclose a substantial difference between RCTs and real-world studies regarding the response to anti-VEGF therapy. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a realworld setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy. These observations mandate large longitudinal studies focusing on the usefulness of these high resolution SD-OCT biomarkers in real-world situations.
Anti Vascular Endothelial Growth Factor Drugs For The Treatment Of Retinal Conditions
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Author : Raywat Deonandan
language : en
Publisher:
Release Date : 2017
Anti Vascular Endothelial Growth Factor Drugs For The Treatment Of Retinal Conditions written by Raywat Deonandan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Retinal conditions, such as age related macular degeneration (AMD), diabetic macular edema (DME), retinal vein occlusion (RVO), and choroidal neovascularization due to pathologic myopia (CNV due to PM) are an important public health concern that threatens the vision of millions of patients in Canada. The mechanism of these conditions involve the new formation of blood vessels in the retina that eventually leads to loss of vision. Anti-vascular endothelial growth factor (Anti-VEGF) inhibits this growth and allows the restoration of vision. Currently in Canada, two licensed anti-VEGF agents are available in the market, ranibizumab and aflibercept. Bevacizumab, on the other hand, has been developed as an anti-cancer drug. However, its close molecular resemblance to ranibizumab and identical mechanism of action has made it a widely used option, especially in environments that are strained on health resources. However, despite the wide use of bevacizumab for retinal conditions, and the availability of several high-quality randomized controlled trials for its efficacy, Bevacizumab still lacks a Health Canada review for retinal indications. The bevacizumab product monograph carries a warning regarding the intravitreal use of bevacizumab, citing increased risk of ophthalmic complications. In addition, the intravenous use of bevacizumab in cancer patients is often associated with increased risk of thromboembolic events (e.g. stroke). The CADTH therapeutic review titled "Anti-Vascular Endothelial Growth Factor Drugs for the Treatment of Retinal Conditions" established that the efficacy of bevacizumab is not different than ranibizumab or aflibercept, and did not observe any signals indicating issues regarding bevacizumab comparative safety. However, the CADTH recommendation report for the therapeutic review identifies the lack of large randomized trials powered to detect differences in harms outcomes as a research gap. The statistical power required to detect a difference in harms outcome can make a randomized clinical trial prohibitive. A review of available evidence regarding safety of bevacizumab from real-world evidence is of high clinical value, as it represents a useful tool for identifying any potential issues regarding the safety of bevacizumab for use in treating retinal conditions. A summary and critical appraisal of studies regarding bevacizumab safety, contrasted with those of ranibizumab and aflibercept, for the treatment of retinal conditions would allow for a more informed and evidence-based policy and clinical decision process.
Indocyanine Green Angiography
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Author : Lawrence A. Yannuzzi
language : en
Publisher:
Release Date : 1997
Indocyanine Green Angiography written by Lawrence A. Yannuzzi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This is the only text available that is devoted exclusively to the ICG imaging technique, its methods and findings. It provides an invaluable guide to this new diagnostic/research tool.
Optical Coherence Tomography Of Ocular Diseases
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Author : Joel S. Schuman
language : en
Publisher: CRC Press
Release Date : 2024-06-01
Optical Coherence Tomography Of Ocular Diseases written by Joel S. Schuman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-01 with Medical categories.
The most comprehensive text and definitive guide for nearly 30 years about optical coherence tomography (OCT) imaging in ophthalmology, Optical Coherence Tomography of Ocular Diseases, Fourth Edition covers a range of subjects, from principles and operation techniques to clinical interpretation and the latest innovations in OCT. Written by the pioneers of OCT technologies and the world-renowned OCT researchers Drs. Joel S. Schuman, James G. Fujimoto, Jay S. Duker, Hiroshi Ishikawa, and Gadi Wollstein, Optical Coherence Tomography of Ocular Diseases, Fourth Edition is an essential text for imaging technology. OCT now occupies a dominant role as a diagnostic tool for retinal conditions and glaucoma. At the same time, the technology continues to show potential for emerging clinical and research applications across all the ophthalmological subspecialties. To reflect these rapid advances, this new edition of Optical Coherence Tomography of Ocular Diseases features a complete and thorough revision of the existing text as well as the addition of cutting-edge content to bring this classic resource completely up to date. New content in the Fourth Edition includes: • OCT angiography • Swept-source OCT • OCT in multimodal imaging • Clinical utility of OCT in glaucoma prediction and progression detection • OCT for neuro-ophthalmology Optical Coherence Tomography of Ocular Diseases, Fourth Edition is the one and only book needed by practitioners who use OCT for clinical eye care.
Encyclopedia Of Ophthalmology
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Author : Ursula Schmidt-Erfurth
language : en
Publisher:
Release Date :
Encyclopedia Of Ophthalmology written by Ursula Schmidt-Erfurth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Ophthalmology categories.
Optical Coherence Tomography In Age Related Macular Degeneration
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Author : Gabriel Coscas
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-25
Optical Coherence Tomography In Age Related Macular Degeneration written by Gabriel Coscas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-25 with Medical categories.
Rapid or even dramatic progress has been made in the field of AMD over recent years, leading to a constant revision of basic concepts. A wide range of fundus imaging modalities are now available, and this book explains the respective value of each technique. The information provided by OCT is presented logically by comparison with plain films, autofluorescence, fluorescein angiography, or indocyanine green angiography. Meticulous biomicroscopic examination of macular changes and the essential value of fluorescein angiography for the detection of anatomical alterations of the macula and for precise evaluation of lesions and their course by indocyanine green angiography have naturally led the author Gabriel Coscas to analyze the new data provided by OCT.
Fundus Fluorescein And Indocyanine Green Angiography
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Author : Amar Agarwal
language : en
Publisher: SLACK Incorporated
Release Date : 2008
Fundus Fluorescein And Indocyanine Green Angiography written by Amar Agarwal and has been published by SLACK Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Fundus Fluorescein and Indocyanine Green Angiography: A Textbook and Atlas is a complete and detailed reference that comprehensively covers fluorescein angiography, the more recent and advancing indocyanine green angiography and their effectiveness in identifying and evaluating various retinal diseases. Prof. Amar Agarwal has teamed up with more than 30 retina specialists to provide eyecare professionals with the most current and essential information for the successful employment and accurate interpretation of these vital diagnostic tests. Sections inside the book include: - Basics and principles - Macular diseases - Vascular retinal diseases - Non vascular retinal diseases - Optic nerve disorders This timely reference uses a unique textbook and atlas format to convey its key points and includes over 550 images and photographs to provide a visual representation of the disease process. Also included is an accompanying CD-ROM with over 35 minutes of supplemental video. Topics on video CD-ROM include: - Fundus fluorescein angiography - Indocyanine green angiography - Optical coherence tomography - Mirror telescopic IOL for macular degenerations With fluorescein and indocyanine green angiography continuing to grow as important and critical diagnostic tests, Fundus Fluorescein and Indocyanine Green Angiography: A Textbook and Atlas will keep ophthalmologists, retina specialists, and optometrists on the cutting edge in today's fast-paced and ever-changing industry. Some topics covered inside include: - Evolution of angiography - Instrumentation - Normal angiograms - Macular holes - Tumors - OCT and spectral OCT