Antimicrobial Immune Response
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Antimicrobial Immune Response
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Author : Maria Del Mar Ortega-Villaizan
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-11-24
Antimicrobial Immune Response written by Maria Del Mar Ortega-Villaizan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
Infectious microbial agents such as viruses, bacteria, fungi, and parasites can cause pathological disorders and even death in organisms exposed to the environment. However, organisms have an immune system to control infection caused by pathogens. The immune system is divided into the innate and the adaptive immune systems. The innate immune system is the first mechanism to respond to infections, whereas the adaptive immune system is based on immune memory. This book provides an overview of antiviral and antibacterial immune responses in different immune-reactive organs and across different animal species, from higher to lower vertebrates.
Antimicrobial Peptides And Innate Immunity
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Author : Pieter S. Hiemstra
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-02-01
Antimicrobial Peptides And Innate Immunity written by Pieter S. Hiemstra and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-01 with Medical categories.
Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
Advances In The Immunology Of Host Defense Peptide Mechanisms And Applications Of Antimicrobial Functions And Beyond
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Author : Mark Hulett
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-07
Advances In The Immunology Of Host Defense Peptide Mechanisms And Applications Of Antimicrobial Functions And Beyond written by Mark Hulett and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-07 with Medical categories.
Antimicrobial Peptides Utility Players In Innate Immunity
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Author : Mark W. Robinson
language : en
Publisher: Frontiers E-books
Release Date :
Antimicrobial Peptides Utility Players In Innate Immunity written by Mark W. Robinson and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Antimicrobial peptides (AMPs) represent an ancient group of molecules with diverse functions in innate immunity. To date, more than 1000 naturally-occurring AMPs have been identified which display considerable diversity in their primary sequences, lengths, structures and biological activities. Despite this variability, AMPs are broadly classified according to homologous secondary structures as cathelicidins (linear a-helical peptides), defensins (ß-strand peptides connected by disulfide bonds) and bactenecins (loop peptides). Most, but not all, AMPs are cationic with amphipathic faces. These biochemical properties bestow many peptides with potent antimicrobial activity by facilitating interactions with negatively charged microbial cell membrane components, thereby increasing membrane permeability and resulting in microbial death. Other indirect effects on microbial physiology have been reported including inhibition of DNA/RNA synthesis, impaired protein synthesis and folding, disruption of cell wall formation and inhibition of microbial cell metabolism. Thus, with the spread of antibiotic-resistant microbial pathogens, AMPs have emerged as exciting candidates for next generation anti-infective therapies. However, recent studies suggest that AMPs have evolved other mechanisms of pathogen clearance. Immunomodulation is a novel approach to antimicrobial therapy that centres on boosting host immunity rather than direct microbial killing. This is also an attractive means to treat sepsis and other immune-mediated diseases. Whilst several cationic peptides are under investigation as antimicrobial agents, a select few show a remarkable ability to protect against lethal endotoxaemia and clinically-relevant bacterial infections including methicillin-resistant Staphylococcus aureus (MRSA). The molecular mechanisms responsible for this protection are only beginning to emerge but include prevention of innate cell activation by targeting key stages of bacterial endotoxin-mediated cell signalling. In this research topic, hosted by Frontiers in Molecular Innate Immunity, we aim to highlight key areas of AMP research including peptide diversity, structure-function relationships, antimicrobial activity and mechanisms of immune-modulation. We also aim to stimulate discussion on the emerging therapeutic potential of AMPs including antifungal, antiviral and anticancer applications.
Antimicrobial Agents And Immunity
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Author : J. Jeljaszewicz
language : en
Publisher:
Release Date : 1986
Antimicrobial Agents And Immunity written by J. Jeljaszewicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Anti-infective agents categories.
Antimicrobial Peptides
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Author : Andrea Giuliani
language : en
Publisher: Methods in Molecular Biology
Release Date : 2010-03-23
Antimicrobial Peptides written by Andrea Giuliani and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-23 with Medical categories.
In this book, leading investigators present a broad, up-to-date collection of current research and experimental methods for the isolation, characterization, production, and optimization of AMPs. The book covers a rapidly expanding field of research.
Trends In Innate Immunity
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Author : Arne Egesten
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2008
Trends In Innate Immunity written by Arne Egesten and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
The last decade has witnessed the delineation of innate immunity - a new area which has revolutionized our understanding of host-parasite interactions and their impact on defense mechanisms in infectious and noninfectious diseases. This volume of the book series 'Contributions to Microbiology' provides an update of the current knowledge of this expanding field of research and highlights some of its most important aspects. In eleven state-of-the-art articles, eminent international experts in the field address topics such as the innate immune system in mammals and insects, microbial protein ligands, antimicrobial peptides, complement, antibacterial chemokines, the role of neutrophils and monocytes, oxidative innate immune defenses and the effect of aging on innate immunity. The book will be a valuable resource for microbiologists, immunologists, students, scientists of other related disciplines, and clinicians with an interest in infectious or immunological diseases.
Immune Response To Biofilms
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Author : Semih Esin
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-02
Immune Response To Biofilms written by Semih Esin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-02 with Medical categories.
Innate Immunity Of Plants Animals And Humans
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Author : Holger Heine
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-07
Innate Immunity Of Plants Animals And Humans written by Holger Heine and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-07 with Science categories.
This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.
Antimicrobial Peptides
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Author : Myung-Dae Seong
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Antimicrobial Peptides written by Myung-Dae Seong and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Immune response categories.
Antimicrobial peptides (AMPs) are small peptides which exhibit broad-spectrum antimicrobial activity and often activity against virus. In addition, AMPs exert several functions including endotoxin neutralization, chemotactic and immunomodulating activities, angiogenesis, and wound repair. In this book, the authors discuss the innate immune system and lipopolysaccharides; the biological role of fish antimicrobial peptides; casein-derived peptides; antimicrobial peptides in intestinal inflammation and infection; insect antimicrobial peptides in immunity and mechanisms of action; potential of AMPs as therapeutic tools against infectious disease; and how LC-MS/MS-based quantitative protein profiling can aid mechanistic studies of antimicrobial peptides.