Antimicrobial Peptides In Gastrointestinal Diseases
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Antimicrobial Peptides In Gastrointestinal Diseases
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Author : Chi Hin Cho
language : en
Publisher: Academic Press
Release Date : 2018-06-06
Antimicrobial Peptides In Gastrointestinal Diseases written by Chi Hin Cho and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-06 with Medical categories.
Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract. Provides an overview of AMPs, particularly cathelicidin and defensin, in different diseases Covers inflammation and ulcer repair in the stomach and colon and carcinogenesis in the GI tract Presents AMP information and knowledge in a concise manner Gives useful information on all aspects of AMPs Promotes research on AMPs and their development as drugs, from bench, to clinical application
Antimicrobial Peptides
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Author : Jürgen Harder
language : en
Publisher: Springer
Release Date : 2015-12-24
Antimicrobial Peptides written by Jürgen Harder and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-24 with Medical categories.
This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.
Antimicrobial Peptides And Innate Immunity
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Author : Pieter S. Hiemstra
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-02-01
Antimicrobial Peptides And Innate Immunity written by Pieter S. Hiemstra and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-01 with Medical categories.
Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
Antimicrobial Peptides
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Author : K. Ajesh
language : en
Publisher: Academic Press
Release Date : 2022-11-23
Antimicrobial Peptides written by K. Ajesh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Medical categories.
Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria Written by internationally recognized experts who provide readers with a wide and useful perspective Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details Addresses the possibility and availability of peptide antibiotics in the global drug market Serves as a complete resource from the discovery to drug development of peptide antibiotics
Antimicrobial Peptides
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Author :
language : en
Publisher:
Release Date : 2003
Antimicrobial Peptides written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Antimicrobial Peptides
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Author : Andrea Giuliani
language : en
Publisher: Methods in Molecular Biology
Release Date : 2010-03-23
Antimicrobial Peptides written by Andrea Giuliani and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-23 with Medical categories.
In this book, leading investigators present a broad, up-to-date collection of current research and experimental methods for the isolation, characterization, production, and optimization of AMPs. The book covers a rapidly expanding field of research.
Immunological Aspects Of Gastroenterology
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Author : Y.R. Mahida
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunological Aspects Of Gastroenterology written by Y.R. Mahida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Diseases of the gastrointestinal tract are common. There is increasing appreciation of the importance of the immune system in the pathogenesis of a number of these diseases. This book covers basic aspects of innate and adaptive immunity in the gastrointestinal tract, oral tolerance, and cellular and molecular mechanisms of acute and chronic inflammation. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease. Other topics include mucosal immunisation and intestinal transplantation immunology. The readership of this book includes clinicians, scientists, and students interested in the gastrointestinal tract.
Advances In The Immunology Of Host Defense Peptide Mechanisms And Applications Of Antimicrobial Functions And Beyond
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Author : Mark Hulett
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-07
Advances In The Immunology Of Host Defense Peptide Mechanisms And Applications Of Antimicrobial Functions And Beyond written by Mark Hulett and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-07 with Medical categories.
Antimicrobial Peptides In Human Health And Disease
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Author : Richard L. Gallo
language : en
Publisher: Taylor & Francis
Release Date : 2005
Antimicrobial Peptides In Human Health And Disease written by Richard L. Gallo and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
This book represents a cutting edge summary of one of the most important fields in innate immunity. Antimicrobial peptides rapidly and directly inhibit infection by microbes and are of enormous importance in the body's natural defence against disease. In addition the role of antimicrobial peptides in the development of therapeutic agents for the prevention and treatment of disease is becoming increasingly important. Written by the leaders in the field this book provides an understanding of the implications of antimicrobial peptides in human disease. The volume is divided into sections containing reviews of specific families of antimicrobials, select organ systems that have demonstrated a relevance for antimicrobial peptides and, in addition, a more global discussion of these peptides and organs from distinct perspectives. Alternatively, each chapter can stand on its own, providing the reader with the ability to dive right into the subject of most interest. Topics covered include cathelicidins, alpha and beta defensins, granulysin, hepcidin, the role of antimicrobial peptides in blood, gut, skin, lung and in the oral environment. A recurring theme is the possibility of creating therapeutics that induce the expression of endogenous antimicrobial peptides for the prevention or treatment of disease.
Antimicrobial Peptides And Human Disease
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Author : William Shafer
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-10-05
Antimicrobial Peptides And Human Disease written by William Shafer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-05 with Medical categories.
Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.