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Antimicrobial Therapies


Antimicrobial Therapies
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Antimicrobial Therapies


Antimicrobial Therapies
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Author : Carlos Barreiro
language : en
Publisher: Humana
Release Date : 2022-05-12

Antimicrobial Therapies written by Carlos Barreiro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-12 with Medical categories.


Antimicrobial resistance will become a global health threat since antimicrobial treatments continue at the forefront of the defense against microbial infections. To respond to the issue, this detailed book explores vital methodologies currently in use to advance our understanding of antibiotic issues and answer the worldwide demand for novel antibiotics therapies. Beginning with a review chapter that guides the reader through the worldwide demand for novel antibiotics therapies, the volume continues with sections covering new screening procedures and environmental sources, advances in analytical, microbiological, and biotechnological methodologies, antibiotic production and antibiotic resistances, as well as considerations of drug trials and clinical concerns regarding multi-resistant patients. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antimicrobial Therapies: Methods and Protocols provides a reference source for health, laboratory, and industrial professionals, as well as for graduate students in a number of bio-sanitary disciplines, including medicine, nursery, biotechnology, veterinary, microbiology, genetics, molecular biology, nutrition, farming, and more. Chapter “14” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.



Facing The Upcoming Of Multidrug Resistant And Extensively Drug Resistant Bacteria Novel Antimicrobial Therapies Nats


Facing The Upcoming Of Multidrug Resistant And Extensively Drug Resistant Bacteria Novel Antimicrobial Therapies Nats
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Author : Angel León-Buitimea
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-01

Facing The Upcoming Of Multidrug Resistant And Extensively Drug Resistant Bacteria Novel Antimicrobial Therapies Nats written by Angel León-Buitimea and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Science categories.




Medicinal Plants And Antimicrobial Therapies


Medicinal Plants And Antimicrobial Therapies
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Author : Vinay Kumar
language : en
Publisher: Springer Nature
Release Date : 2024-01-04

Medicinal Plants And Antimicrobial Therapies written by Vinay Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-04 with Medical categories.


This book serves as an excellent comprehensive material covering the current understandings and updates on antimicrobial resistance (AMR) and the use of medicinal plant resources for tackling it. Chapters cover important aspects of AMR and strategies to address this threatening issue with medicinal plants and their resources. One health perspectives for addressing AMR have been presented for the readers. Antimicrobial medicinal plant therapeutic resources including crude extracts, active fractions, pure molecules and essential oils, besides using them as functionalizing agents for nano-antimicrobials have been covered. Further, plant endophytes as a source of antimicrobial compounds have been discussed. Chapters cover both the bactericidal as well as resistance-reversal (or potentiating/ combinatorial therapies) potencies of medicinal plant resources. The book also focuses on how medicinal plant resources effectively target major determinants of AMR. Use of metabolomics in understanding and targeting AMR mechanisms and identifying potent phyto-therapeutics has been discussed as well. The book is a valuable read for both experienced and younger researchers working in the field of AMR and related fields in biomedicine, pharmacy, and clinical research.



Antimicrobial Therapy In Veterinary Medicine


Antimicrobial Therapy In Veterinary Medicine
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Author : Steeve Giguère
language : en
Publisher: John Wiley & Sons
Release Date : 2013-07-25

Antimicrobial Therapy In Veterinary Medicine written by Steeve Giguère and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-25 with Medical categories.


The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.



Challenges To Tackling Antimicrobial Resistance Economic And Policy Responses


Challenges To Tackling Antimicrobial Resistance Economic And Policy Responses
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2020-04-01

Challenges To Tackling Antimicrobial Resistance Economic And Policy Responses written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-01 with categories.


Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.



Antibiotic Alternatives And Combinational Therapies For Bacterial Infections


Antibiotic Alternatives And Combinational Therapies For Bacterial Infections
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Author : Sanna Sillankorva
language : en
Publisher: Frontiers Media SA
Release Date : 2019-03-20

Antibiotic Alternatives And Combinational Therapies For Bacterial Infections written by Sanna Sillankorva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-20 with categories.


The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.” As Alexander Fleming predicted already in 1945 bacteria have become resistant to antibiotics. From time to time we are bombarded with news of infections and deaths caused by antibiotic resistant and multiple drug resistant superbugs. This increase of resistance towards commonly used antibiotics due to decades of use, misuse and abuse of antibiotics, is today a global health concern. Research investments on development of new antimicrobials that can fight antimicrobial resistant microorganisms are scarce yet some new antibiotic discoveries have been described recently. Nevertheless, the advent of antibiotic failure due to bacterial resistance has brought interest in other alternative therapies. Natural products from microbial origin are examples of such alternative therapies. Bacteriophages are bacterial viruses and consequently bacterial natural enemies and together with their derived enzymes are efficient towards antibiotic resistant bacteria. Antimicrobial peptides (AMP), natural compounds with alternative mechanisms of action, are short-length peptides present in a variety of sources and in many forms. AMP have been recognized as promising candidates for replacing classical antimicrobials due to their multiple mechanisms of action and general low specificity in terms of molecular targets, which reduces the chance of acquired resistance. Quorum sensing inhibitors (QSI) are destabilisers of key communication mechanisms that regulate virulence and the establishment of biofilm-related infections.



Antibiotic Optimization


Antibiotic Optimization
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Author : Robert C. Owens
language : en
Publisher: CRC Press
Release Date : 2004-11-04

Antibiotic Optimization written by Robert C. Owens and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-04 with Medical categories.


This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi



Bacterial Resistance To Antimicrobials


Bacterial Resistance To Antimicrobials
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Author : Richard G Wax
language : en
Publisher: CRC Press
Release Date : 2019-08-30

Bacterial Resistance To Antimicrobials written by Richard G Wax and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.


The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.



Potential Novel Antimicrobial Therapies For Burn Wounds Peptides And Cold Plasma


Potential Novel Antimicrobial Therapies For Burn Wounds Peptides And Cold Plasma
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Author :
language : en
Publisher:
Release Date : 2021

Potential Novel Antimicrobial Therapies For Burn Wounds Peptides And Cold Plasma written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.


More than 40 AMPs have been studied in clinical trials but only a few AMPs have been approved for clinical use against bacterial infections. Based on the literature review (Chapter 2), clinical trials using AMPs have been discontinued due to unexpected toxicity or unfavorable pharmacokinetics of peptides. However, the majority of AMPs were not approved due to lack of efficacy or superiority of AMPs over conventional antibiotics or treatments. To improve the performance of AMPs, several strategies are available such as chemical modifications, the preparation of delivery systems and specifically targeted AMPs (STAMPs), combination therapy and counter-ion selection during the final step of AMP synthesis. In addition to these strategies, an increasing number of AMPs might reach the clinic if clinical trial regulatory bodies could shift their focus from superiority trials to equivalence or non-inferiority trials (i.e. clinical trials whereby the performance of AMPs should be similar to that of antibiotics or standard treatments). One of the causes of unexpected and unfavorable performance of AMPs in trials might be the overestimated efficacy of AMPs due to inaccurate in vitro testing. To accurately and appropriately determine efficacy of antimicrobials, it is important to neutralize the remaining active antimicrobials before microbiological assessment of the number of surviving bacteria. Without effective neutralization, efficacy of antimicrobials could be overestimated due to ongoing bacterial killing during sample preparations. We studied the ability of sodium polyanethol sulfonate (SPS) to neutralize the bactericidal activity of several antimicrobials (Chapter 3). SPS effectively inactivated positively charge antimicrobials and therefore, we have used this neutralizing agent in all subsequent efficacy tests of the positively charged peptide SAAP-148.



Bacterial Resistance To Antimicrobials Second Edition


Bacterial Resistance To Antimicrobials Second Edition
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Author : Richard G. Wax
language : en
Publisher: CRC Press
Release Date : 2007-12-05

Bacterial Resistance To Antimicrobials Second Edition written by Richard G. Wax and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-05 with Science categories.


The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.