Antisense Oligodeoxynucleotides And Antisense Rna
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Antisense Oligodeoxynucleotides And Antisense Rna
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Author : Benjamin Weiss
language : en
Publisher: CRC Press
Release Date : 1997-06-23
Antisense Oligodeoxynucleotides And Antisense Rna written by Benjamin Weiss and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-23 with Medical categories.
A practical, up-to-date treatise on this technology and its potential application in therapeutics. It features critical analyses of the specificity of the agents, and the possibility of antisense oligomers acting through non-antisense mechanisms. The history of early development of antisense oligodeoxynucleotides and their chemical modification to increase their stability is followed by delivery and penetration into cells, non-antisense effects of antisense oligonucleotides, pharmacokinetic properties; in vitro and in vivo model systems, and clinical trials.
Modulating Gene Expression By Antisense Oligonucleotides To Understand Neural Functioning
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Author : Margaret M. McCarthy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Modulating Gene Expression By Antisense Oligonucleotides To Understand Neural Functioning written by Margaret M. McCarthy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in peripheral systems, largely because of its enormous success. The source of this success remains a matter of some controversy. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same vagaries and pitfalls as non-neuronal systems. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning contains chapters by experts in the field that focus on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning features: experts in the field reporting on the use of antisense oligonucleotide technology in a variety of behavioral systems, including pain control, circadian rhythms, ingestion and control of water balance, and reproductive behaviors; the novel use of plasmids to express antisense RNA in the nervous system; the biodistribution and metabolism of antisense oligonucleotides in the nervous system; rapid and unusual effects; and non-specific effects.
Antisense Research And Applications
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Author : Stanley T. Crooke
language : en
Publisher: CRC Press
Release Date : 1993-05-27
Antisense Research And Applications written by Stanley T. Crooke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-05-27 with Medical categories.
Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
Antisense Drug Technology
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Author : Stanley T. Crooke
language : en
Publisher: CRC Press
Release Date : 2007-07-25
Antisense Drug Technology written by Stanley T. Crooke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-25 with Medical categories.
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati
Antisense Elements Genetics Research Focus
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Author : A. G. Hernandes
language : en
Publisher: Nova Publishers
Release Date : 2007
Antisense Elements Genetics Research Focus written by A. G. Hernandes and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Antisense RNA categories.
Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes. Some regions within a double strand of DNA code for genes, which are usually instructions specifying the order of amino acids in a protein along with regulatory sequences, splicing sites, non-coding introns and other complicating details. For a cell to use this information, one strand of the DNA serves as a template for the synthesis of a complementary strand of RNA. The template DNA strand is called the transcribed strand with antisense sequence and the mRNA transcript is said to be sense sequence (the complement of antisense). Because the DNA is double-stranded, the strand complementary to the antisense sequence is called non-transcribed strand and has the same sense sequence as the mRNA transcript (though T bases in DNA are substituted with U bases in RNA). This book presents important new research from around the world in this field.
Antisense Technology Part A General Methods Methods Of Delivery And Rna Studies
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Author :
language : en
Publisher: Elsevier
Release Date : 1999-11-01
Antisense Technology Part A General Methods Methods Of Delivery And Rna Studies written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-01 with Science categories.
Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedical-oriented research. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Antisense Nucleic Acids And Proteins
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Author : Joseph N. M. Mol
language : en
Publisher: CRC Press
Release Date : 1991-01-24
Antisense Nucleic Acids And Proteins written by Joseph N. M. Mol and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-24 with Science categories.
A compilation of papers from many different scientific meetings in recent years, this reference source reviews the use of antisense nucleic acids to modulate or down-regulate gene expression, provides clues on the action mechanism of sense and antisense genes as well as data on antisense nucleic aci
Gene Regulation
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Author : Robert P. Erickson
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1992
Gene Regulation written by Robert P. Erickson and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Examines the biology of antisense oligodeoxynucleotides, RNA and ribozymes, and explores their potential therapeutic applications, particularly for inhibition of viral replication and cancer gene expression. Close attention is also given to drug approval.
Oligonucleotide Based Drugs And Therapeutics
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Author : Nicolay Ferrari
language : en
Publisher: John Wiley & Sons
Release Date : 2018-07-31
Oligonucleotide Based Drugs And Therapeutics written by Nicolay Ferrari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-31 with Medical categories.
A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.
Antisense Research And Application
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Author : Stanley T. Crooke
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antisense Research And Application written by Stanley T. Crooke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.