Antiviral Drug Resistance
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Antiviral Drug Resistance
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Author : Douglas D. Richman
language : en
Publisher: Wiley
Release Date : 1996-12-02
Antiviral Drug Resistance written by Douglas D. Richman and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-02 with Medical categories.
The study of antiviral drug resistance has provided important insights into the structure of virus enzymes, the functions of certain genes, mechanisms of action of antiviral drugs, the design of new antiviral compounds and the pathogenesis of viral diseases. The emergence of resistant strains must be explored at all stages of drug development: during the preclinical evaluation of candidate compounds; during the early clinical evaluation of new drugs; and as part of epidemiological surveillance for the prevalence of resistance during use of approved treatments. Accumulating understanding of antiviral drug resistance thus reflects progress in the chemotherapy of viral infection. Antiviral Drug Resistance provides state-of-the-art coverage of the basic and clinical aspects of this subject. It deals with the basic science, including the mechanisms of drug resistance and drug action, genetics of drug resistance, cross resistance, and X-ray crystallographic structural aspects of resistance, as well as the clinical aspects, including issues of assay of susceptibility of clinical isolates, descriptive aspects of emergence of reduced susceptibility, and clinical significance and impact of resistance. As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy.
Antiviral Drug Discovery And Development
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Author : Xinyong Liu
language : en
Publisher: Springer Nature
Release Date : 2021-07-13
Antiviral Drug Discovery And Development written by Xinyong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-13 with Medical categories.
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Biochemistry Of Drug Resistance
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Author : Sarfraz Ahmed
language : en
Publisher: Springer Nature
Release Date : 2021-08-05
Biochemistry Of Drug Resistance written by Sarfraz Ahmed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-05 with Medical categories.
This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included.
Antiviral Drug Resistance Of Herpes Simplex Virus
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Author : R0užena Stránská
language : en
Publisher:
Release Date : 2004
Antiviral Drug Resistance Of Herpes Simplex Virus written by R0užena Stránská and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
New Concepts Of Antiviral Therapy
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Author : Elke Bogner
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-31
New Concepts Of Antiviral Therapy written by Elke Bogner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-31 with Medical categories.
Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.
Abstracts Presented At The International Workshop On Antiviral Drug Resistance Meeting The Global Challenge Meeting The Global Challenge
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Author :
language : en
Publisher:
Release Date : 2014
Abstracts Presented At The International Workshop On Antiviral Drug Resistance Meeting The Global Challenge Meeting The Global Challenge written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Antiviral Drug Development
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Author : Erik De Clercq
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antiviral Drug Development written by Erik De Clercq and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Antimicrobial Drug Resistance
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Author : L Bryan
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Antimicrobial Drug Resistance written by L Bryan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Health & Fitness categories.
Antimicrobial Drug Resistance presents information regarding the ability of organisms to resist natural and synthetically derived inhibitors. It presents the view of the authors who made significant contributions to the understanding of resistance. The book focuses on inhibitors classified as antifungal, antiviral, and antimalarial, as well as metal ions. It also covers numerous reactions, which have been genetically and biochemically analyzed in this context. Additionally, some chapters cover resistance plasmids of most of the clinically important bacteria. The book is designed to aid those involved in microbiological and pharmaceutical research on antimicrobial agents, clinical infectious diseases and medical microbiology, teaching microbiology and pharmacology, pharmaceutical marketing, and infection control.
Antimicrobial Drug Resistance Clinical Aspects
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Author : Armando Guerrero
language : en
Publisher: American Medical Publishers
Release Date : 2021-11-16
Antimicrobial Drug Resistance Clinical Aspects written by Armando Guerrero and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-16 with Medical categories.
Antimicrobial drug resistance is defined as the ability to resist the effects of medication by a microbe. Resistance can be developed through three mechanisms. These are natural resistance, genetic mutation and acquired resistance. Such resistance can be developed by all classes of microbes. These classes include bacteria, fungi, virus and protozoa. Bacteria develop antibiotic resistance, fungi develop antifungal resistance, viruses develop antiviral resistance, and protozoa develop antiprotozoal resistance. Growing resistance is mainly caused by the excessive use of antimicrobials by humans and animals. Its preventive measures have been undergoing through further research. These researches include alternating therapy, phage therapy, new drug development and use of vaccines. This book presents the clinical aspects of antimicrobial drug resistance in the most comprehensible and easy to understand language. It consists of contributions made by international experts. The book will serve as a valuable source of reference for graduate and postgraduate students.
Comprehensive Analysis Of Hepatitis B Virus Antiviral Drug Resistance Mutations Based On A New High Throughput Phenotypic Assay
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Author : Ke Zhang
language : en
Publisher:
Release Date : 2013
Comprehensive Analysis Of Hepatitis B Virus Antiviral Drug Resistance Mutations Based On A New High Throughput Phenotypic Assay written by Ke Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.