Apathy Is Associated With Disruption To Distinct Large Scale White Matter Networks
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Apathy Is Associated With Disruption To Distinct Large Scale White Matter Networks
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Author : Jonathan Tay
language : en
Publisher:
Release Date : 2017
Apathy Is Associated With Disruption To Distinct Large Scale White Matter Networks written by Jonathan Tay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Background and AimsApathy is a common and debilitating syndrome in many neurological conditions, but its underlying neurobiology remains poorly understood. This complicated by depression, an overlapping but distinct neuropsychiatric syndrome. Research has shown that apathy, but not depression, is associated with widespread white matter damage. We test the hypothesis that apathy is a disconnection syndrome using network analysis to study the relationships between apathy and white matter networks in patients with cerebral small vessel disease (SVD), a vascular pathology characterised by white matter damage.Method331 SVD patients completed measures of apathy and depression and underwent MRI. White matter networks were constructed using DTI and tractography. First, path analysis was used to test the mediating effect of network integrity on the relationship between radiological markers of SVD and apathy. Second, we examined differences in whole brain measures of network integrity between participants with only apathy, only depression, comorbid apathy and depression, and a control SVD group free of neuropsychiatric symptoms. Finally, we examined regional network correlations with apathy while controlling for depression.ResultsPath analysis results indicated that the relationship between SVD markers and apathy was fully mediated by network integrity. Between-group comparisons revealed that SVD patients with apathy, when compared to other SVD patients, were impaired on whole brain measures of network density and efficiency. Regression analyses revealed that apathy was primarily associated with connectivity in medial premotor and frontostriatal regions.ConclusionThese results suggest that apathy is caused by the disconnection of white matter tracts underlying action initiation and effort-based decision-making for reward.
Management Of Post Stroke Complications
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Author : Ajay Bhalla
language : en
Publisher: Springer
Release Date : 2015-05-19
Management Of Post Stroke Complications written by Ajay Bhalla and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-19 with Medical categories.
This book highlights the underlying importance of post-stroke complications during recovery, allowing healthcare professionals managing stroke patients to understand their frequency and identify which patients are at risk of developing such complications. Complications are categorised into neurological and non-neurological, and the time-frame for these complications both in the short-term and long-term are discussed. The common practices in managing post-stroke complications and the skills required in their prevention are described, as is the evidence base from clinical trials around their management. The book concludes with a discussion of new developments and research priorities for the future. Management of Post-Stroke Complications is aimed at members of the multidisciplinary stroke team, stroke physicians, neurologists, general practitioners, stroke specialists in training, and medical students.
Subcortical Vascular Dementia
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Author : Rita Moretti
language : en
Publisher: Nova Publishers
Release Date : 2006
Subcortical Vascular Dementia written by Rita Moretti and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Brain categories.
Vascular dementia is one of the most common forms of mental deterioration for the elderly, second only to Alzheimer's disease. It should not be defined as a single disease, but rather as a group of syndromes that relate to different vascular mechanisms. This is one of the first books to be solely dedicated to the specific class of vascular dementia known as subcortical vascular dementia. The strict focus of the chapters give an depth review that will clarify many different aspects and give an unprecedented amount of detail about this clinical problem. Considering that vascular dementia can be prevented with early diagnosis, the research presented in this book will be important for both students and specialists of this important field.
Oxford Textbook Of Epilepsy And Epileptic Seizures
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Author : Samden Lhatoo
language : en
Publisher: Oxford University Press, USA
Release Date : 2012-12-20
Oxford Textbook Of Epilepsy And Epileptic Seizures written by Samden Lhatoo and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-20 with Medical categories.
Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.
Neuroimaging Of Brain Structure Function Coupling Mechanism In Neuropsychiatric Disorders
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Author : Junghun Cho
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-07
Neuroimaging Of Brain Structure Function Coupling Mechanism In Neuropsychiatric Disorders written by Junghun Cho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Science categories.
Cingulate Neurobiology And Disease
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Author : Brent Vogt
language : en
Publisher: Oxford University Press, USA
Release Date : 2009-06-04
Cingulate Neurobiology And Disease written by Brent Vogt and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-04 with Medical categories.
One of the major neuroscience publications of the past few years, Cingulate Neurobiology and Disease presents the definitive review of the cingulate cortex, explaining its critical role in a host of diseases and illnesses.
Assembly Of The Executive Mind
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Author : Michael W. Hoffmann
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-10
Assembly Of The Executive Mind written by Michael W. Hoffmann and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Medical categories.
Understand the neuro-archeology of the executive brain, in its supervisory function, to better treat illnesses and behavior.
Cerebral Small Vessel Disease
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Author : Leonardo Pantoni
language : en
Publisher: Cambridge University Press
Release Date : 2014-05
Cerebral Small Vessel Disease written by Leonardo Pantoni and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05 with Medical categories.
Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
White Matter Dementia
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Author : Christopher M. Filley
language : en
Publisher: Cambridge University Press
Release Date : 2016-04-28
White Matter Dementia written by Christopher M. Filley and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-28 with Medical categories.
Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.
Textbook Of Stroke Medicine
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Author : Michael Brainin
language : en
Publisher: Cambridge University Press
Release Date : 2014-09-11
Textbook Of Stroke Medicine written by Michael Brainin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-11 with Medical categories.
Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.