Apoptosis And Reproduction
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Cell Death In Reproductive Physiology
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Author : Jonathan L. Tilly
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Death In Reproductive Physiology written by Jonathan L. Tilly and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The regulation of cell death in various reproductive tissues, as in other ma jor organ systems of the body, has become a focal point of research activity in many laboratories over the past few years. As such, the need for a "for mal" meeting to highlight recent work in this field, as well as to integrate knowledge from other sources (such as investigators working on cell death in cancer and immune function) in the broad context of identifying con served pathways that coordinate life-and-death decisions in diverse cell types, became apparent. Therefore, the goals of the Scientific Committee of the International Symposium on Cell Death in Reproductive Physiology, spon sored by Serono Symposia USA, were already predetermined by this need. Simply stated, we sought to bring together for the first time a select cohort of reproductive biologists and cell death researchers, many but not all cho sen based on their pioneering efforts in elucidating the fundamental aspects of apoptosis in reproductive and nonreproductive tissues, as a means to re view the current status of the field, foster new ideas, and promote scientific collaborations. In the ensuing chapters of this book, summaries of work dis cussed at the meeting are presented to emphasize both the diversity and the similarities in the occurrence and regulation of apoptosis in tissues of the male and female reproductive systems.
Apoptosis And Reproduction
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Author :
language : en
Publisher:
Release Date : 1997
Apoptosis And Reproduction written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Apoptosis categories.
Apoptosis And Reproduction
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Author : Hideharu Kanzaki
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1997-01-01
Apoptosis And Reproduction written by Hideharu Kanzaki and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Medical categories.
Apoptosis Related Signaling In The Reproductive System
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Author : Ido Ben-Ami
language : en
Publisher:
Release Date : 2009
Apoptosis Related Signaling In The Reproductive System written by Ido Ben-Ami and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Sex And The Origins Of Death
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Author : William R. Clark
language : en
Publisher: Oxford University Press
Release Date : 1998-06-11
Sex And The Origins Of Death written by William R. Clark and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-06-11 with Science categories.
Death, for bacteria, is not inevitable. Protect a bacterium from predators, and provide it with adequate food and space to grow, and it would continue living--and reproducing asexually--forever. But a paramecium (a slightly more advanced single-cell organism), under the same ideal conditions, would stop dividing after about 200 generations--and die. Death, for paramecia and their offspring, is inevitable. Unless they have sex. If at any point during that 200 or so generations, two of the progeny of our paramecium have sex, their clock will be reset to zero. They and their progeny are granted another 200 generations. Those who fail to have sex eventually die. Immortality for bacteria is automatic; for all other living beings--including humans--immortality depends on having sex. But why is this so? Why must death be inevitable? And what is the connection between death and sexual reproduction? In Sex and the Origins of Death, William R. Clark looks at life and death at the level of the cell, as he addresses such profound questions as why we age, why death exists, and why death and sex go hand in hand. Clark reveals that there are in fact two kinds of cell death--accidental death, caused by extreme cold or heat, starvation, or physical destruction, and "programmed cell death," initiated by codes embedded in our DNA. (Bacteria have no such codes.) We learn that every cell in our body has a self-destruct program embedded into it and that cell suicide is in fact a fairly commonplace event. We also discover that virtually every aspect of a cell's life is regulated by its DNA, including its own death, that the span of life is genetically determined (identical twins on average die 36 months apart, randomly selected siblings 106 months apart), that human tissue in culture will divide some 50 times and then die (an important exception being tumor cells, which divide indefinitely). But why do our cells have such programs? Why must we die? To shed light on this question, Clark reaches far back in evolutionary history, to the moment when "inevitable death" (death from aging) first appeared. For cells during the first billion years, death, when it occurred, was accidental; there was nothing programmed into them that said they must die. But fierce competition gradually led to multicellular animals--size being an advantage against predators--and with this change came cell specialization and, most important, germ cells in which reproductive DNA was segregated. When sexual reproduction evolved, it became the dominant form of reproduction on the planet, in part because mixing DNA from two individuals corrects errors that have crept into the code. But this improved DNA made DNA in the other (somatic) cells not only superfluous, but dangerous, because somatic DNA might harbor mutations. Nature's solution to this danger, Clark concludes, was programmed death--the somatic cells must die. Unfortunately, we are the somatic cells. Death is necessary to exploit to the fullest the advantages of sexual reproduction. In Sex and the Origins of Death, William Clark ranges far and wide over fascinating terrain. Whether describing a 62-year-old man having a major heart attack (and how his myocardial cells rupture and die), or discussing curious life-forms that defy any definition of life (including bacterial spores, which can regenerate after decades of inactivity, and viruses, which are nothing more than DNA or RNA wrapped in protein), this brilliant, profound volume illuminates the miraculous workings of life at its most elemental level and finds in these tiny spaces the answers to some of our largest questions.
Apoptosis
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Author : C. S. Potten
language : en
Publisher: Cambridge University Press
Release Date : 2004-08-16
Apoptosis written by C. S. Potten and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-16 with Medical categories.
The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.
The Role Of Apoptosis In Development Tissue Homeostasis And Malignancy
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Author : T. Michael Dexter
language : en
Publisher: Springer Science & Business Media
Release Date : 1995-06-30
The Role Of Apoptosis In Development Tissue Homeostasis And Malignancy written by T. Michael Dexter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-06-30 with Medical categories.
The past five years have witnessed a remarkable development of interest in cell death 'from inside out'. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in its regulation, and its significance in the pathogenesis of diseases of major social importance are becoming clear. Moreover, because a distinct set of biological events is involved in this death, these events themselves become reason able targets for new pharmacological agents in the treatment of cancer. The articles in this volume summarize the contents of a discussion meeting held at the Royal Society on 23 and 24 February 1994. The authors are a distinguished international group from a variety of disciplines in biology and medicine and hopefully their articles will convey something of the excitement of this fast-moving field. The three organizers are enormously indebted to all the contributors for the enthusiasm with which they delivered their talks, shared in discussion, and finally committed their contributions to these printed pages. We would also like to acknowledge the gracious way in which the Royal Society hosted the meeting, and in particular Mary Manning for making it the trouble-free and enjoyable experience that it was, and Janet Clifford and Simon Gribbin for skillfully managing the editorial processing of this volume. Michael Dexter June 1994 Martin Raff Andrew Wyllie x 1 Death from inside out: an overVIew ANDREW H.
Cell Apoptosis Research Advances
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Author : Carter R. Kettleworth
language : en
Publisher: Nova Publishers
Release Date : 2007
Cell Apoptosis Research Advances written by Carter R. Kettleworth and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This book presents research from around the world.
Regulation Of Apoptosis In The Female Reproductive System
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Author : Tommi Vaskivuo
language : en
Publisher:
Release Date : 2002
Regulation Of Apoptosis In The Female Reproductive System written by Tommi Vaskivuo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Apoptosis In Toxicology
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Author : R. J. Roberts
language : en
Publisher: CRC Press
Release Date : 1999-12-02
Apoptosis In Toxicology written by R. J. Roberts and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-02 with Medical categories.
Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiato