Apoptosis In Carcinogenesis And Chemotherapy
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Apoptosis In Carcinogenesis And Chemotherapy
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Author : George G. Chen
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-02-22
Apoptosis In Carcinogenesis And Chemotherapy written by George G. Chen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-22 with Medical categories.
Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.
Apoptosis And Cancer Chemotherapy
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Author : John A. Hickman
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-04-08
Apoptosis And Cancer Chemotherapy written by John A. Hickman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-08 with Medical categories.
The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.
Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy
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Author : Christopher D. Gregory
language : en
Publisher: Springer
Release Date : 2016-08-24
Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy written by Christopher D. Gregory and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-24 with Medical categories.
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Application Of Apoptosis To Cancer Treatment
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Author : Mels Sluyser
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-04-14
Application Of Apoptosis To Cancer Treatment written by Mels Sluyser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-14 with Medical categories.
Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world’s leading experts in these fields.
Apoptosis Senescence And Cancer
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Author : David A. Gewirtz
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-17
Apoptosis Senescence And Cancer written by David A. Gewirtz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-17 with Medical categories.
Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.
Apoptosis In Hormone Dependent Cancers
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Author : Martin Tenniswood
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Apoptosis In Hormone Dependent Cancers written by Martin Tenniswood and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
It is now widely accepted that cells have the ability to initiate a program of gene-directed death, a process called "apoptosis" which may also be used as an innovative strategy for therapeutic intervention in cancer therapy. Experts in this area report on the regulation and control of apoptosis in hormone dependent (neoplastic) tissue and the possibility to exploit active cell death for therapeutic application.
Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases
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Author : Marek Los
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-20
Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases written by Marek Los and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-20 with Medical categories.
As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.
Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy
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Author : Benjamin Bonavida
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-31
Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy written by Benjamin Bonavida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-31 with Medical categories.
This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.
Apoptosis And Cancer
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Author : Seamus J. Martin
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1997
Apoptosis And Cancer written by Seamus J. Martin and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Apoptosis categories.
The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.
Molecular Mechanisms Of Tumor Cell Resistance To Chemotherapy
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Author : Benjamin Bonavida
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-04
Molecular Mechanisms Of Tumor Cell Resistance To Chemotherapy written by Benjamin Bonavida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-04 with Medical categories.
This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.