Apoptosis Induction Suppression A Feasible Approach For Natural Products To Treatment Of Diseases Volume Ii
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Apoptosis Induction Suppression A Feasible Approach For Natural Products To Treatment Of Diseases Volume Ii
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Author : Hong Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-30
Apoptosis Induction Suppression A Feasible Approach For Natural Products To Treatment Of Diseases Volume Ii written by Hong Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-30 with Science categories.
Apoptosis Induction Suppression A Feasible Approach For Natural Products To Treatment Of Diseases
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Author : Hong Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-13
Apoptosis Induction Suppression A Feasible Approach For Natural Products To Treatment Of Diseases written by Hong Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-13 with Science categories.
Herbal Medicine
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Author : Iris F. F. Benzie
language : en
Publisher: CRC Press
Release Date : 2011-03-28
Herbal Medicine written by Iris F. F. Benzie and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-28 with Health & Fitness categories.
The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
Apoptosis And Cancer
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Author : Seamus J. Martin
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1997
Apoptosis And Cancer written by Seamus J. Martin and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Apoptosis categories.
The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.
Epigenetic Approaches In Drug Discovery Development And Treatment
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Author : Shibashish Giri
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-07
Epigenetic Approaches In Drug Discovery Development And Treatment written by Shibashish Giri and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-07 with categories.
Establishment of a normal phenotype involves dynamic epigenetic regulation of gene expression that when affected contributes to human diseases. On a molecular level, epigenetic regulation is marked by specific covalent modifications (acetylation, methylation, phosphorylation, sumoylation, PARylation and ubiquitylation) of DNA and its associated histones. Studies also suggest the influence of such epigenetic modifications on non-coding RNA expression implicated in normal and diseased phenotypes. Epigenetic control of genetic expression is a reversible process essential for normal development and function of an organism. Alteration of epigenetic regulation leads to various disease forms such as cancer, diabetes, inflammation and neuropsychiatric disorders. Assessing these alterations provides a deeper insight into the changes induced in the genome, which is often informative for identifying disease subtypes or developing suitable treatments. Therefore, epigenetics proves to be a key area of clinical investigation in diagnosis, prognosis, and treatment of complex diseases. Genetic mutations, environmental stress, pathogens and drugs of abuse are some of the predominant factors that induce and impact changes on chromatin, which directly dictate a diseased phenotype. It is essential to consider the interaction between genetic and epigenetic factors to understand the molecular mechanisms of complex human diseases for safer and efficient drug development. Furthermore, genetic variation in absorption, distribution, metabolism, and excretion (ADME) genes is insufficient to account for interindividual variability of drug response. Therefore, current efforts aim to identify epigenetic components of ADME gene regulation, which include phase-I and phase-II enzymes, uptake transporters, efflux transporters and nuclear receptors involved in regulation of ADME genes. Monitoring circulatory epigenetic biomarkers in liquid biopsies (blood, saliva, urine, cerebrospinal fluid) of disease-associated and drug-associated epigenetic alterations may prove useful for decision support for routine clinical treatment and drug discovery. Hence, recent drug discovery efforts on targeting the epigenome, has emerged an area of interest with several new drugs being developed, tested and some already approved by the US Food and Drug Administration (FDA). These new insights into the complexities of epigenetic regulation are key contributors to our basic understanding of this process in human health and disease, which will provide scope for innovative drug therapies. It is of urgency to aid the present understanding of epigenomics driven diseased outcomes, with the expectation that further studies will identify early markers of disease and targets for therapeutics.
Cell Surface Grp78 A New Paradigm In Signal Transduction Biology
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Author : Salvatore V. Pizzo
language : en
Publisher: Academic Press
Release Date : 2018-03-20
Cell Surface Grp78 A New Paradigm In Signal Transduction Biology written by Salvatore V. Pizzo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-20 with Science categories.
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative
Cancer Research
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Author :
language : en
Publisher:
Release Date : 2008-06
Cancer Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06 with Cancer categories.
Heat Shock Proteins In Cancer
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Author : Stuart K. Calderwood
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-09
Heat Shock Proteins In Cancer written by Stuart K. Calderwood and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-09 with Medical categories.
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics
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Author : Tao Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-05
Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics written by Tao Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Science categories.
Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity
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Author : Fang Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-09
Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity written by Fang Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-09 with Medical categories.
Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.