Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity

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Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity

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Author : Fang Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-09

Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity written by Fang Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-09 with Medical categories.

Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.

Tolerogenic Dendritic Cells And Regulatory T Cells As Therapeutics For Immune Mediated Disorders

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Author : Djordje Miljkovic
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-16

Tolerogenic Dendritic Cells And Regulatory T Cells As Therapeutics For Immune Mediated Disorders written by Djordje Miljkovic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-16 with Medical categories.

Signaling Mechanisms Regulating T Cell Diversity And Function

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Author : Taylor & Francis Group
language : en
Publisher: CRC Press
Release Date : 2021-03-30

Signaling Mechanisms Regulating T Cell Diversity And Function written by Taylor & Francis Group and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with categories.

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

The Molecular Mechanisms Of Regulatory T Cell Immunosuppression

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Author : Kendall A. Smith
language : en
Publisher: Frontiers E-books
Release Date :

The Molecular Mechanisms Of Regulatory T Cell Immunosuppression written by Kendall A. Smith and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 production and action, and the production of suppressive cytokines such as IL-10 and Tumor Growth Factor-beta, to list a few. However, the field has thus far failed to come to a consensus, such that some investigators have now asserted that many molecular mechanisms may be operative, in fact that perhaps all of the described mechanisms may account for the suppressive effects of these cells, acting either simultaneously or sequentially. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for T-Reg immunosuppression.

Principles Of Immunopharmacology

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Author : Frans P. Nijkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-01

Principles Of Immunopharmacology written by Frans P. Nijkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Medical categories.

This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This third edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.

Encyclopedia Of Immunobiology

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Author :
language : en
Publisher: Academic Press
Release Date : 2016-04-27

Encyclopedia Of Immunobiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with Medical categories.

Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

Immune System Disorders From Molecular Mechanisms To Clinical Implications

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Author : Mauricio César De Marzi
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-17

Immune System Disorders From Molecular Mechanisms To Clinical Implications written by Mauricio César De Marzi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-17 with Medical categories.

In recent years, the increase in knowledge about the functioning of the immune system has revealed not only its importance in the defense against external agents such as pathogens or toxins, but also in the control of tumor cells and the importance of the processes of inflammation or immunological tolerance. On the one hand, all this knowledge has allowed a better understanding of the putative pathogenic consequences of immune system dysfunction, which includes inflammatory, autoimmune and immunosuppressive diseases, among others. On the other hand, current knowledge about immunoregulation has paved the way to better prevent or control transplantation rejection. However, such mechanisms underlying immune dysregulation are highly variable depending on the type of pathology (systemic chronic inflammatory diseases, autoinflammatory diseases, autoimmune disorders, immunosuppression) and on characteristics of the host such as sex, genetics, nutritional status, etc. Given the wide variety of pathologies that are a consequence of excessive, inefficient or inadequate induction of immune responses, the study of factors involved in the dysregulation of the immune system has gained great attention during the last decades.

Research Awards Index

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Author :
language : en
Publisher:
Release Date : 1989

Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.

Csir Net Life Science Unit 14 Immunology

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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-07-15

Csir Net Life Science Unit 14 Immunology written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-15 with Science categories.

EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels.

Cumulated Index Medicus

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Author :
language : en
Publisher:
Release Date : 1993

Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medicine categories.