Applications Of Mass Spectrometry Imaging To Cancer
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Applications Of Mass Spectrometry Imaging To Cancer
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-01-19
Applications Of Mass Spectrometry Imaging To Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-19 with Medical categories.
Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Applications Of Mass Spectrometry Imaging To Cancer
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-02-10
Applications Of Mass Spectrometry Imaging To Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-10 with Medical categories.
Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Maldi Mass Spectrometry Imaging
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Author : Tiffany Siegel Porta
language : en
Publisher: Royal Society of Chemistry
Release Date : 2021-12-03
Maldi Mass Spectrometry Imaging written by Tiffany Siegel Porta and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-03 with Science categories.
This book gathers knowledge about matrix-assisted laser desorption ionisation (MALDI) mass spectrometry imaging for postgraduate and professional researchers in academia and in industry where it has direct application to clinical research.
Medical Applications Of Mass Spectrometry
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Author : Karoly Vekey
language : en
Publisher: Elsevier
Release Date : 2011-08-11
Medical Applications Of Mass Spectrometry written by Karoly Vekey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-11 with Science categories.
Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.* Guides the reader from basic principles and methods to cutting edge applications.* There is NO comparable book on the market to fill this fast growing field.
Imaging Mass Spectrometry
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Author : Laura M Cole
language : en
Publisher: Springer Nature
Release Date : 2023-07-06
Imaging Mass Spectrometry written by Laura M Cole and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-06 with Science categories.
This second edition details new and updated chapters on key methodologies and breakthroughs in the mass spectrometry imaging (MSI) field. Chapters guide readers through nano-Desorption Electrospray Ionisation (nDESI), Matrix Assisted Laser Desorption Ionisation-2 (MALDI-2), Laser Ablation - Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) ,Imaging Mass Cytometry (IMC) with a variety of diverse samples including eye tissue, crop analysis, 3D cell culture models, and counterfeit goods analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Imaging Mass Spectrometry: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Cancer Metabolomics
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Author : Shen Hu
language : en
Publisher: Springer Nature
Release Date : 2021-04-01
Cancer Metabolomics written by Shen Hu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Medical categories.
Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
Method Development And Application Of Mass Spectrometry For Better Understanding Of Disease Mechanisms And Diagnosis
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Author : Yuan Liu (Ph. D.)
language : en
Publisher:
Release Date : 2023
Method Development And Application Of Mass Spectrometry For Better Understanding Of Disease Mechanisms And Diagnosis written by Yuan Liu (Ph. D.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Mass spectrometry is a very powerful tool for identifying and quantifying biomolecules of interest, including metabolites, drug compounds, proteins, and post-translational modifications of (PTMs) of proteins. In mass spectrometry (MS)-based analytical techniques, liquid-chromatography coupled with tandem mass spectrometry (LC-MS/MS) is widely used for biomolecule analysis, including relative and absolute quantification of metabolites, proteins and PTMs. Data dependent acquisition (DDA) and data-independent acquisition (DIA) are two main methods for quantification of biomolecules in LC-MS/MS. By integrating isotopic and/or isobaric tags labeling, the DDA method enables precise absolute quantification and high-throughput analysis of biomolecules, facilitating biomarker discovery and elucidation of disease mechanisms. In contrast, DIA has garnered significant interest due to its exceptional reproducibility and depth in identifying and quantifying biomolecules. In this dissertation work, I apply these isotopic/isobaric tag labeling and label-free strategies to investigate potential biomarkers in the serum of Alzheimer's disease (AD) and colorectal cancer (CRC). Additionally, I explore the crosstalk between pancreatic stellate cells and pancreatic cancer cells using multi-faceted MS approaches.In addition to LC-MS/MS, mass spectrometry imaging (MSI) offers unparalleled insights into the spatial distribution of biomolecules across organs, tissues, and cell cultures, further enhancing our understanding of biological systems. We develop a tagging method to enhance the identification, quantification, and visualization of amine-containing metabolites by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. Furthermore, I optimize a workflow for rapid sample preparation and high throughput MSI of biomolecule distribution in a widely used three-dimensional cell culture system - spheroids. In summary, the integration of various mass spectrometry techniques and method development discussed in this dissertation demonstrates that combining different mass spectrometry approaches can provide a more comprehensive molecular picture of the complex biological system, ultimately enhancing our understanding of disease mechanisms and advancing diagnosis and treatment options.
Advances In Maldi And Laser Induced Soft Ionization Mass Spectrometry
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Author : Rainer Cramer
language : en
Publisher: Springer
Release Date : 2015-11-09
Advances In Maldi And Laser Induced Soft Ionization Mass Spectrometry written by Rainer Cramer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-09 with Science categories.
This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics
Imaging Mass Spectrometry Application In Colorectal Cancer Liver Metastasis Pathological Evaluation
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Author : Balqis Alabdulkarim
language : en
Publisher:
Release Date : 2016
Imaging Mass Spectrometry Application In Colorectal Cancer Liver Metastasis Pathological Evaluation written by Balqis Alabdulkarim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
"Colorectal Cancer (CRC) is the second leading cause of cancer mortality in North America. Death from CRC is largely due to metastatic disease and the liver is the most common site of distant metastasis. Surgery when feasible carries the only chance of cure for Colorectal Cancer Liver Metastasis (CRCLM) patients. Post surgical resection further patient management and choice of adjuvant chemotherapy relies on pathological assessment of tumor grade. Multiple histopathologic assessment methods have been developed with variable correlation with patients' outcome. Until recently the Tumor Regression Grade (TRG) had the strongest correlation with patients' outcome. It scores lesions according to the ratio of fibrosis against the sum of viable tumor and necrosis. However with the widespread use of anti-angiogenic agents that causes necrosis as a form of response in the preoperative setting the modified Tumor Regression Grade (mTRG) evolved. It differentiates between two types of necrosis with different prognostic roles, Usual Necrosis (UN) and Infarct-Like Necrosis (ILN). Nonetheless pathological evaluation remains limited by its subjective nature. Our works describes the use of Matrix Assisted Laser Desorption and Ionization (MALDI) imaging mass spectrometry (IMS) to generate lipid signatures for different topographies. To do so we initially applied a semi-supervised histology driven approach to build our spectral library using an automated clustering method (k-means) and direct visual histological correlations (5-stain panel) on a training set (n=12). We identified six histologically correlated lipid signatures and further mined them for discriminate lipid markers. We used partial Least Squares-Discriminant Analysis (PLS-DA) to implement our spectral library on an independent validation cohort (n=40). Additionally, by dissecting out the lipid signatures we have identified single lipid moieties that are unique to UN and ILN that could potentially be used as new biomarkers for assessing response to therapy. Using these signatures and lipid markers we obtained a histologically quantitative and objective mTRG score. " --
Mass Spectrometry In Cancer Research
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Author : John Roboz
language : en
Publisher: CRC Press
Release Date : 2002-03-25
Mass Spectrometry In Cancer Research written by John Roboz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-25 with Medical categories.
Cancer research is becoming multidisciplinary. The complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and more and more mass spectrometry. Mass Spectrometry in Cancer Research provides a broad