Applied Epigenomic Epidemiology Essentials
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Applied Epigenomic Epidemiology Essentials
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Author : Laurens Holmes, Jr.
language : en
Publisher: Taylor & Francis
Release Date : 2023-12-01
Applied Epigenomic Epidemiology Essentials written by Laurens Holmes, Jr. and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-01 with Medical categories.
This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice. Epidemiology has a vital strategic role in facilitating and leading evidence discovery in all aspects of human health, with the intent of improving patient and public health through disease control and health promotion practices. It emphasizes what we now know about the transformation the human body and the ecosystem undergo as a result of social structure, environment, daily challenges and mutation. The first part of this text explores the origin of epidemiology, its relationship with medicine and public health, and its role in assessing disease distribution as occurrence or frequency, risk factors, treatment and management. The main direction of this text is to explore the assessment of how gene and environment interactions, termed epigenomic modulations, aberrantly predispose to morbidity, prognosis, survival and mortality at the individual as well as the specific population level. This text presents a novel approach based mainly on epigenomic modulations in the application of epidemiologic investigation in disease incidence, morbidity and mortality at a specific population level for graduate education in public health and clinical sciences as well as medical education.
Applied Epigenomic Epidemiology Essentials
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Author : Jr. Holmes, Laurens (Nemours Healthcare System Wilmington Delaware USA)
language : en
Publisher: Routledge
Release Date : 2023-12
Applied Epigenomic Epidemiology Essentials written by Jr. Holmes, Laurens (Nemours Healthcare System Wilmington Delaware USA) and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12 with categories.
This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice. Epidemiology has a vital strategic role in facilitating and leading evidence discovery in all aspects of human health, with the intent of improving patient and public health through disease control and health promotion practices. Emphasizing what we now know about the transformation the human body and the ecosystem undergo as a result of social structure, environment, daily challenges, and mutation. The first part of this text explores the origin of epidemiology, its relationship with medicine and public health, and its role in assessing disease distribution as occurrence or frequency, risk factors, treatment and management. The main direction of this text explores the assessment of how the gene and environment interaction, termed epigenomic modulations as aberrant predispose to morbidity, prognosis, survival and mortality at individual as well as the specific population level. This text presents a novel approach mainly epigenomic modulations in the application epidemiologic investigation in disease incidence, morbidity, and mortality at specific population level for graduate education in public health and clinical sciences as well as medical education.
Epigenetic Epidemiology
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Author : Karin B. Michels
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-03
Epigenetic Epidemiology written by Karin B. Michels and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-03 with Medical categories.
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!
Principles Of Genetics And Molecular Epidemiology
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Author : Juan Carlos Gomez-Verjan
language : en
Publisher: Springer Nature
Release Date : 2022-01-28
Principles Of Genetics And Molecular Epidemiology written by Juan Carlos Gomez-Verjan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-28 with Science categories.
This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.
Molecular Epidemiology
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Author : Paul A. Schulte
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Molecular Epidemiology written by Paul A. Schulte and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Epigenetic Epidemiology
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Author : Karin B. Michels
language : en
Publisher: Springer Nature
Release Date : 2022-04-14
Epigenetic Epidemiology written by Karin B. Michels and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-14 with Science categories.
Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation. Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizes the latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.
Twin And Family Studies Of Epigenetics
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Author : Shuai Li
language : en
Publisher: Academic Press
Release Date : 2021-08-19
Twin And Family Studies Of Epigenetics written by Shuai Li and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-19 with Medical categories.
Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field
Dna Methylation And Complex Human Disease
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Author : Michel Neidhart
language : en
Publisher: Academic Press
Release Date : 2015-08-11
Dna Methylation And Complex Human Disease written by Michel Neidhart and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-11 with Science categories.
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
Applied Epidemiologic Principles And Concepts
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Author : Laurens Holmes, Jr.
language : en
Publisher: CRC Press
Release Date : 2017-12-14
Applied Epidemiologic Principles And Concepts written by Laurens Holmes, Jr. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-14 with Medical categories.
This book provides practical knowledge to clinicians and biomedical researchers using biological and biochemical specimen/samples in order to understand health and disease processes at cellular, clinical, and population levels. Concepts and techniques provided will help researchers design and conduct studies, then translate data from bench to clinics in attempt to improve the health of patients and populations. This book presents the extreme complexity of epidemiologic research in a concise manner that will address the issue of confounders, thus allowing for more valid inferences and yielding results that are more reliable and accurate.
Clinical Genetics And Genomics Of Aging
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Author : Juan Carlos Gomez-Verjan
language : en
Publisher: Springer
Release Date : 2021-04-14
Clinical Genetics And Genomics Of Aging written by Juan Carlos Gomez-Verjan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-14 with Medical categories.
The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.