Applying An Implementation Science Approach To Genomic Medicine

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Applying An Implementation Science Approach To Genomic Medicine

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-08-06

Applying An Implementation Science Approach To Genomic Medicine written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-06 with Medical categories.

Although it is becoming increasingly more common for clinicians to use genomic data in their practices for disease prevention, diagnosis, and treatment, the process of integrating genomic data into the practice of medicine has been a slow and challenging one. Some of the major barriers impeding the incorporation of new genomic technology into clinical practice are: the difficulty of changing routine medical practices to account for the use of genetic testing, the limited knowledge of patients and providers about genomic medicine, assessing sufficient evidence to support the use of genetic tests, privacy and data security issues, and uncertainty about reimbursement. The field of implementation science may be able to provide insights concerning efficient ways to incorporate genomic applications into routine clinical practice. The focus of implementation science studies is to identify integration bottlenecks and optimal approaches for a given setting and ultimately to promote the up-take of research findings. To explore the potential of implementation science to improve the integration of genomics into medicine, the National Academies of Sciences, Engineering, and Medicine held a workshop in Washington, DC, in November 2015. Participants explored the challenges and opportunities of integrating genomic advances into the clinic through the lens of implementation science. This report summarizes the presentations and discussions from the workshop.

Implementing And Evaluating Genomic Screening Programs In Health Care Systems

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2018-06-16

Implementing And Evaluating Genomic Screening Programs In Health Care Systems written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-16 with Medical categories.

Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. This trend can be attributed to a variety of factors, including the declining cost of genome sequencing and the potential for improving health outcomes and cutting the costs of care. The goals of these genomics-based programs may be to identify individuals with clinically actionable variants as a way of preventing disease, providing diagnoses for patients with rare diseases, and advancing research on genetic contributions to health and disease. Of particular interest are genomics- based screening programs, which will, in this publication, be clinical screening programs that examine genes or variants in unselected populations in order to identify individuals who are at an increased risk for a particular health concern (e.g., diseases, adverse drug outcomes) and who might benefit from clinical interventions. On November 1, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop to explore the challenges and opportunities associated with integrating genomics-based screening programs into health care systems. This workshop was developed as a way to explore the challenges and opportunities associated with integrating genomics-based programs in health care systems in the areas of evidence collection, sustainability, data sharing, infrastructure, and equity of access. This publication summarizes the presentations and discussions from the workshop.

Translational Orthopedics

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Author : Jeffrey A. Bakal
language : en
Publisher: Elsevier
Release Date : 2024-04-15

Translational Orthopedics written by Jeffrey A. Bakal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.

Translational Orthopedics: Designing and Conducting Translational Research covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in translational orthopedics, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in translational orthopedics, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every Medical Researcher or Orthopedist who has ever had a good clinical idea but not the knowledge of how to test it. - Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within orthopedics - Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation - Details discussions of the critical appraisal of published studies in translational orthopedics, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care

Genomics Driven Healthcare

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Author : Yashwant Pathak
language : en
Publisher: Springer
Release Date : 2018-07-02

Genomics Driven Healthcare written by Yashwant Pathak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-02 with Medical categories.

This book evaluates trends arising in “-Omics” sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology. Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.

Sustaining The Implementation Of Evidence Based Interventions In Clinical And Community Settings

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Author : Nicole Nathan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-24

Sustaining The Implementation Of Evidence Based Interventions In Clinical And Community Settings written by Nicole Nathan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-24 with Medical categories.

Aging Research Methodological Issues

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Author : Carmen García-Peña
language : en
Publisher: Springer
Release Date : 2018-09-25

Aging Research Methodological Issues written by Carmen García-Peña and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-25 with Medical categories.

This is the second edition of a well received book that reviews classical epidemiological and clinical research designs, with a specific focus on aging. Chapters cover basic topics like the scientific method, ethics, and the consequences of certain exclusion criteria. The work also includes a look at clinical concepts like multimorbidity, frailty and functionality. New material includes chapters such as geroscience, health systems research, big data and data mining, financing and future of aging research. The authors reveal the issues and challenges for researchers of age and aging, and also consider, from basic to clinical, and from clinical to public policies of social and health care. The focus on aging is what gives this book its valuable perspective on research methodology. All authors have considerable experience in aging, geriatrics or gerontology, and each chapter includes both a theoretical framework and practical examples of studies in aging. Readers will discover study designs that are reviewed for basic structure, main flaws and advantages, and are analyzed for specific conditions and variables regarding aging. This text is suited to both health care professionals caring for older adults, and researchers who are new to research in aging. It is relevant across the disciplines, including medicine, psychology, social sciences and dentistry, and it supports learning with graphs and figures.

Handbook Of Health Psychology

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Author : Tracey A. Revenson
language : en
Publisher: Routledge
Release Date : 2018-12-07

Handbook Of Health Psychology written by Tracey A. Revenson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-07 with Psychology categories.

This rich resource provides a thorough overview of current knowledge and new directions in the study of the biological, psychological, social, and cultural factors that affect health, health behavior, and illness. Chapters review the latest theories and research with an emphasis on how research is translated into behavioral medicine interventions. Featuring contributions from top researchers and rising stars in the field, authors provide a theoretical foundation; evaluate the empirical evidence; and make suggestions for future research, clinical practice, and policy. The handbook reflects the latest approaches to health psychology today, including: Emphasis throughout on the socio-cultural aspects of health, including socioeconomic status, gender, race/ethnicity, sexual orientation, and age/developmental stage A new section on emerging areas in health psychology, including behavioral genomics, military veterans' health, and digital health Coverage of prevention, interventions, and treatment in the applications section An expansion of the biopsychosocial model across several levels of analysis, including cultural, macro-social, and cellular factors Sustained emphasis on translating research into practice and policy The handbook considers the intersections of concepts (behavior change), populations (women's and sexual minority health), cultural groups (African American, Asian American, and Latino), risk and protective factors (obesity, coping), and diseases (cancer, diabetes, HIV), making it essential reading for scholars of health psychology, public health, epidemiology, and nursing. Novices to the field appreciate the accessibly written chapters, while seasoned professionals appreciate the book's deep, cutting-edge coverage.

Using Nursing Research To Shape Health Policy

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Author : Patricia A. Grady
language : en
Publisher: Springer Publishing Company
Release Date : 2017-03-15

Using Nursing Research To Shape Health Policy written by Patricia A. Grady and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Medical categories.

Examining the crucial interrelationship between nursing research and health policy, this book presents examples of specific health care policy that has been influenced, implemented, or changed as a result of nursing research. It builds on the discussion of this relationship as described in the editors' earlier book, Shaping Health Policy through Nursing Research, named a Doody's Core Title in 2013 and an AJN Book of the Year in 2011. This current edition updates earlier information with new nursing research by esteemed scholars. It encompasses research related to major policy statements of the decade, including the IOM Future of Nursing report, the Affordable Care Act, and the Blueprint for Genomics in Nursing, and highlights how they have influenced, and will continue to influence, health policy. Written for multiple audiences including undergraduate and graduate students, faculty, and nursing professionals, the book presents information on how science shapes health policy in general, models and strategies for linking research and health policy, and multiple examples of how major nursing research has influenced health policy. The text provides both a conceptual orientation and an operational approach to strategies linking research to policy and influencing policy makers at the organizational, community, state, national, and international levels. Key Features: Offers examples of cutting edge nursing research that provides a foundation for practice and policy Incorporates major policy directives of this decade and highlights how nursing research has influenced health policy Demonstrates to undergraduate and graduate students, faculty, and nursing professionals how nursing research can shape health policy decisions Includes perspectives, models and strategies for using nursing research to influence health policy Addresses how nursing research shapes policy at organizational, community, state, national, and international levels

Medical And Health Genomics

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Author : Dhavendra Kumar
language : en
Publisher: Academic Press
Release Date : 2016-06-04

Medical And Health Genomics written by Dhavendra Kumar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-04 with Science categories.

Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. - Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management - Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study - Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management - Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems

Genomic And Precision Medicine

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Author : Geoffrey S. Ginsburg
language : en
Publisher: Academic Press
Release Date : 2022-04-09

Genomic And Precision Medicine written by Geoffrey S. Ginsburg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-09 with Science categories.

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. - Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers - Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice - Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice - Covers case studies that highlight the practical use of genomics in the management of patients