Aptamers
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Aptamers For Analytical Applications
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Author : Yiyang Dong
language : en
Publisher: John Wiley & Sons
Release Date : 2019-02-11
Aptamers For Analytical Applications written by Yiyang Dong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-11 with Science categories.
An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.
Aptamers
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Author : Rakesh N. Veedu
language : en
Publisher: CRC Press
Release Date : 2017-03-03
Aptamers written by Rakesh N. Veedu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-03 with Medical categories.
Aptamers, often termed as ‘chemical antibodies,’ are an emerging class of synthetic ligands for efficient target-specific molecular recognition. The objective of this book is to highlight recent advances and potential of aptamers in various disease conditions. . This book focuses on the applications of aptamers in targeted nanotherapy, detection, and in molecular imaging in various disease conditions such as cancer, neurological diseases and infectious diseases.
Aptamers For Medical Applications
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Author : Yiyang Dong
language : en
Publisher: Springer Nature
Release Date : 2021-03-25
Aptamers For Medical Applications written by Yiyang Dong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-25 with Science categories.
This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.
Aptamers For Food Applications
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Author : Yiyang Dong
language : en
Publisher: Elsevier
Release Date : 2023-05-27
Aptamers For Food Applications written by Yiyang Dong and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-27 with Science categories.
Aptamers for Food Applications: Safety, Authenticity, and Integrity outlines the main applications of aptamers to ensure food safety, quality and compliance that are crucial for food science, public health and human sustainability. Aptamers or aptamer-based analytical devices are comprehensively summarized to tackle various food contamination or food adulteration problems. Topics covered in this book include aptamers for foodborne microbial pathogens, pesticide or veterinary drug residues, heavy metals, biotoxins, abused food additives, illegal food adulterants, POPs, GMOs, food allergens and food contact material migrants. It is therefore of interest for not only analytical investigators and food safety inspectors, but also regulatory practitioners and risk assessors in various food science and research fields. Presents the versatilities of aptamers for food safety, quality and compliance Provides utilities of aptamers for the analysis of almost all risk factors in foodstuffs Includes food quality control and regulatory measures such as HACCP, MRLs, proficiency test and uncertainty assessment, along with case illustrations
Aptamers
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Author : Gulab Singh Yadav
language : en
Publisher: Springer Nature
Release Date : 2019-11-11
Aptamers written by Gulab Singh Yadav and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Science categories.
The book discusses the basics of aptamers and the advent of aptamer-based technology in recent times. The book covers the diverse applications of aptamers, such as in detection of animal and plant pathogens, disease diagnosis and therapeutics, environmental contamination detection etc. Besides these applications, the book also describes the use of these synthetic or modified DNA, as drug delivery vehicles. The different chapters describe how the binding capacity and specificity of aptamers can be exploited in various ways. The book also discusses how these attributes of aptamers can outdo the antibody technology in biomedical and diagnostic solutions. This crisp and concise book gives the readers an insight into the most recent biotechnological applications of aptamers.
Nucleic Acid Aptamers
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Author : Günter Mayer
language : en
Publisher: Springer Nature
Release Date : 2022-09-26
Nucleic Acid Aptamers written by Günter Mayer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-26 with Science categories.
This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers’ interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.
Aptamers Selected By Cell Selex For Theranostics
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Author : Weihong Tan
language : en
Publisher: Springer
Release Date : 2015-03-02
Aptamers Selected By Cell Selex For Theranostics written by Weihong Tan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-02 with Science categories.
This edited volume describes cell-SELEX as the fundamental tool used to generate aptamer molecules for a wide range of applications in molecular medicine, bioanalysis and chemical biology. Easily integrated into the natural heterogeneous cell matrix, aptamers can be effectively used in theranostics, bioanalysis, environment detection and biomedical studies. The book gathers reviews that reflect the latest advances in the field of aptamers and consists in fourteen chapters demonstrating essential examples of these aptamers and aptamer-nanomaterial assemblies, depending on the types of applications and biological systems. It also includes a separate chapter on the utilization of aptamers in real clinics and what will be required to achieve this significant goal. The book will be both appealing and useful to a broad audience, including biologists, bioscientists, and clinicians whose interests range from chemistry and biomedical engineering to cell and molecular biology and biotechnology. Weihong Tan is a Distinguished Professor of Chemistry and Biomedical Engineering at Hunan University, China and also a University of Florida Distinguished Professor and V.T. and Louis Jackson Professor of Chemistry at the University of Florida, USA. Xiaohong Fang is a Professor at the Institute of Chemistry, Chinese Academy of Sciences, China.
Aptamers In Biotechnology
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Author : Katharina Urmann
language : en
Publisher: Springer Nature
Release Date : 2020-07-31
Aptamers In Biotechnology written by Katharina Urmann and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with Science categories.
This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology.
Aptamers In Bioanalysis
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Author : M. Mascini
language : en
Publisher: John Wiley & Sons
Release Date : 2009-04-27
Aptamers In Bioanalysis written by M. Mascini and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-27 with Science categories.
This is the first book to detail bioanalytical technologies and methods that have been developed using aptamers in analytical, medical, environmental, and food science applications. After an introduction to aptamers, aptamer targets, and their general uses, it discusses different applications with particular attention to the comparison between aptamer-based biosensors and methods versus the corresponding immunosensors. Examples of aptamer-based diagnostic techniques include whole-cell protein profiling (proteomics) and medical diagnostics for the distinction of diseased versus healthy states. This is a core reference for analytical chemists, electrochemists, pharmaceutical/medicinal chemists, biotechnologists, and others.
Aptamers Engineered Nanocarriers For Cancer Therapy
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Author : Prashant Kesharwani
language : en
Publisher: Woodhead Publishing
Release Date : 2022-09-25
Aptamers Engineered Nanocarriers For Cancer Therapy written by Prashant Kesharwani and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-25 with Technology & Engineering categories.
Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy. Reviews the mechanisms behind multi-drug resistance (MDR) in cancer and how aptamer-mediated novel therapeutic agents and strategies can facilitate MDR reversal Covers a range of aptamers engineered nanostructures, including PLGA nanoparticles, silica nanoparticles, quantum dots, nucleic acid aptamers, and more Discusses the challenges associated with using aptamers as cancer therapeutics and how this translates into clinical use