Artemisinin Based And Other Antimalarials
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Artemisinin Based And Other Antimalarials
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Author : Guoqiao Li
language : en
Publisher: Academic Press
Release Date : 2017-11-28
Artemisinin Based And Other Antimalarials written by Guoqiao Li and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-28 with Medical categories.
Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery
Artemisinin Based And Other Antimalarials
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Author : Guoqiao Li
language : en
Publisher: Academic Press
Release Date : 2017-11-28
Artemisinin Based And Other Antimalarials written by Guoqiao Li and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-28 with Medical categories.
Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.
Artemisinin Based And Other Antimalarials
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Author : Keith Arnold
language : en
Publisher:
Release Date : 2018
Artemisinin Based And Other Antimalarials written by Keith Arnold and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Antimalarials categories.
Pharmacokinetics And Pharmacodynamics Of Antimalarial Drugs Used In Combination Therapy
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Author : Qigui Li
language : en
Publisher: Bentham Science Publishers
Release Date : 2015-06-04
Pharmacokinetics And Pharmacodynamics Of Antimalarial Drugs Used In Combination Therapy written by Qigui Li and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-04 with Medical categories.
Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.
Saving Lives Buying Time
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2004-09-09
Saving Lives Buying Time written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-09 with Medical categories.
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Antimalarial Chemotherapy
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Author : Philip J. Rosenthal
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-04-01
Antimalarial Chemotherapy written by Philip J. Rosenthal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-04-01 with Medical categories.
Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.
From Artemisia Annua L To Artemisinins Hindi Edition
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Author : Youyou Tu
language : en
Publisher:
Release Date : 2021-10-31
From Artemisia Annua L To Artemisinins Hindi Edition written by Youyou Tu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-31 with categories.
From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.
Treatment And Prevention Of Malaria
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Author : Henry M. Staines
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-06
Treatment And Prevention Of Malaria written by Henry M. Staines and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-06 with Medical categories.
Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
Economic Analysis Of Malaria Control In Sub Saharan Africa
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Author : Catherine Cavallaro Goodman
language : en
Publisher:
Release Date : 2000
Economic Analysis Of Malaria Control In Sub Saharan Africa written by Catherine Cavallaro Goodman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Africa, Sub-Saharan categories.
Antimalarial Natural Products
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Author : A. Douglas Kinghorn
language : en
Publisher: Springer Nature
Release Date : 2022-01-02
Antimalarial Natural Products written by A. Douglas Kinghorn and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-02 with Science categories.
This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.