Assessing The Functional Structure Of Molecular Transporters By Epr Spectroscopy
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Assessing The Functional Structure Of Molecular Transporters By Epr Spectroscopy
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Author : Matthias J.N.Junk
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-05
Assessing The Functional Structure Of Molecular Transporters By Epr Spectroscopy written by Matthias J.N.Junk and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-05 with Technology & Engineering categories.
In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
Electron Paramagnetic Resonance Spectroscopy
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Author : Patrick Bertrand
language : en
Publisher: Springer Nature
Release Date : 2020-02-03
Electron Paramagnetic Resonance Spectroscopy written by Patrick Bertrand and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Science categories.
This book shows how the fundamentals of electron paramagnetic resonance (EPR) spectroscopy are practically implemented and illustrates the diversity of current applications. The technique is used at various levels, and applications are presented in order of increasing difficulty, with reference to theoretically obtained results. This book features a diverse array of application examples, from fields such as ionizing radiation dosimetry, neurodegenerative diseases, structural transitions in proteins, and the origins of terrestrial life. The final chapter of this book highlights the principles and applications of the technique of ferromagnetic resonance spectroscopy, followed by a brief introduction to advanced EPR techniques such as electron spin echo envelope modulation (ESEEM), hyperfine sub-level correlation (HYSCORE), pulsed electron-electron double resonance (PELDOR), and continuous wave electron nuclear double resonance (ENDOR) experiments.
Cmos Circuits For Biological Sensing And Processing
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Author : Srinjoy Mitra
language : en
Publisher: Springer
Release Date : 2017-11-18
Cmos Circuits For Biological Sensing And Processing written by Srinjoy Mitra and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-18 with Technology & Engineering categories.
This book provides the most comprehensive and consistent survey of the field of IC design for Biological Sensing and Processing. The authors describe a multitude of applications that require custom CMOS IC design and highlight the techniques in analog and mixed-signal circuit design that potentially can cross boundaries and benefit the very wide community of bio-medical engineers.
Assessing The Functional Structure Of Molecular Transporters By Epr Spectroscopy
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Author :
language : en
Publisher:
Release Date : 2010
Assessing The Functional Structure Of Molecular Transporters By Epr Spectroscopy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
In this thesis, the self-assembled functional structure of a broad range of amphiphilic molecular transporters is studied. By employing paramagnetic probe molecules and ions, continuous-wave and pulse electron paramagnetic resonance spectroscopy reveal information about the local structure of these materials from the perspective of incorporated guest molecules. First, the transport function of human serum albumin for fatty acids is in the focus. As suggested by the crystal structure, the anchor points for the fatty acids are distributed asymmetrically in the protein. In contrast to the crystallographic findings, a remarkably symmetric entry point distribution of the fatty acid binding channels is found, which may facilitate the uptake and release of the guest molecules. Further, the metal binding of 1,2,3-triazole modified star-shaped cholic acid oligomers is studied. These biomimetic molecules are able to include and transport molecules in solvents of different polarity. A pre-arrangement of the triazole groups induces a strong chelate-like binding and close contact between guest molecule and metal ion. In absence of a preordering, each triazole moiety acts as a single entity and the binding affinity for metal ions is strongly decreased. Hydrogels based on N-isopropylacrylamide phase separate from water above a certain temperature. The macroscopic thermal collapse of these hydrogels is utilized as a tool for dynamic nuclear polarization. It is shown that a radical-free hyperpolarized solution can be achieved with a spin-labeled gel as separable matrix. On the nanoscale, these hydrogels form static heterogeneities in both structure and function. Collapsed regions protect the spin probes from a chemical decay while open, water-swollen regions act as catalytic centers. Similarly, thermoresponsive dendronized polymers form structural heterogeneities, which are, however, highly dynamic. At the critical temperature, they trigger the aggregation of the polymer into mesogl.
Computational Techniques For Analytical Chemistry And Bioanalysis
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Author : Philippe B. Wilson
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-10
Computational Techniques For Analytical Chemistry And Bioanalysis written by Philippe B. Wilson and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-10 with Science categories.
This work will serve as a definitive overview of the field of computational simulation as applied to analytical chemistry and biology, drawing on recent advances as well as describing essential, established theory for graduates and postgraduate researchers.
Amino Acids Peptides And Proteins
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Author : Maxim Ryadnov
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-12-06
Amino Acids Peptides And Proteins written by Maxim Ryadnov and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-06 with Science categories.
A Structure Function Toolbox For Membrane Transporter And Channels
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-08-17
A Structure Function Toolbox For Membrane Transporter And Channels written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Medical categories.
A Structure-Function Toolbox for Membrane Transporter and Channels, Volume 594, a new release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters in the updated serial include Cryo-EM on membrane proteins embedded in nanodics, Solid-Supported membrane-based electrophysiology on membrane transporters and channels, Saposin-lipoprotein scaffolds for structure determination of membrane transporters and channels, Single-molecule FRET on transporters, Dynamics of channels and transporters investigated by NMR, Structure-function studies on channels and transporters, and a section on MemStar, a new GFP-based expression and purification system for transporters and channels. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers membrane transporter and channels
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1993
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medicine categories.
Biophysical Chemistry
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-02-19
Biophysical Chemistry written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-19 with Science categories.
Biophysical chemistry is one of the most interesting interdisciplinary research fields. Some of its different subjects have been intensively studied for decades. Now the field attracts not only scientists from chemistry, physics, and biology backgrounds but also those from medicine, pharmacy, and other sciences. We aimed to start this version of the book Biophysical Chemistry from advanced principles, as we include some of the most advanced subject matter, such as advanced topics in catalysis applications (first section) and therapeutic applications (second section). This led us to limit our selection to only chapters with high standards, therefore there are only six chapters, divided into two sections. We have assumed that the interested readers are familiar with the fundamentals of some advanced topics in mathematics such as integration, differentiation, and calculus and have some knowledge of organic and physical chemistry, biology, and pharmacy. We hope that the book will be valuable to graduate and postdoctoral students with the requisite background, and by some advanced researchers active in chemistry, biology, biochemistry, medicine, pharmacy, and other sciences.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1989
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.