Astrocytes In Patho Physiology Of The Nervous System


Astrocytes In Patho Physiology Of The Nervous System
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Astrocytes In Patho Physiology Of The Nervous System


Astrocytes In Patho Physiology Of The Nervous System
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Author : Vladimir Parpura
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-11

Astrocytes In Patho Physiology Of The Nervous System written by Vladimir Parpura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-11 with Medical categories.


Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.



Astrocytes In Patho Physiology Of The Nervous System


Astrocytes In Patho Physiology Of The Nervous System
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Author : Vladimir Parpura
language : en
Publisher:
Release Date : 2011-03-21

Astrocytes In Patho Physiology Of The Nervous System written by Vladimir Parpura and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-21 with categories.




Astrocytes Pt 3 Biochemistry Physiology And Pharmacology Of Astrocytes


Astrocytes Pt 3 Biochemistry Physiology And Pharmacology Of Astrocytes
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Author : Sergey Fedorff
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Astrocytes Pt 3 Biochemistry Physiology And Pharmacology Of Astrocytes written by Sergey Fedorff and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.


Astrocytes: Cell Biology and Pathology of Astrocytes, Volume 3 deals with the involvement of astrocytes in neurological and neuropathological states of brain function. This volume discusses the expression of astrocyte-specific immunological markers and plasma membrane structures; the dynamics of the cytoskeleton and cell cycle; and the reactivity to injury and response of astrocytes in selected pathological and genetic states. The text also aims to inspire new ideas and research on astrocyte functions as well as on the pathogenesis of neurological disorders. Neuroscientists, cell biologists, clinicians, neuropathologists, and pediatric neurologists will find the book invaluable.



Glial Physiology And Pathophysiology


Glial Physiology And Pathophysiology
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Author : Alexei Verkhratsky
language : en
Publisher: John Wiley & Sons
Release Date : 2013-01-31

Glial Physiology And Pathophysiology written by Alexei Verkhratsky and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-31 with Medical categories.


Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides



Astrocytes In Psychiatric Disorders


Astrocytes In Psychiatric Disorders
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Author : Baoman Li
language : en
Publisher: Springer Nature
Release Date : 2021-12-09

Astrocytes In Psychiatric Disorders written by Baoman Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-09 with Medical categories.


This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.



Astrocyte


Astrocyte
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Author : Maria Teresa Gentile
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-03-21

Astrocyte written by Maria Teresa Gentile and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-21 with Medical categories.


A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.



Biology And Pathology Of Astrocyte Neuron Interactions


Biology And Pathology Of Astrocyte Neuron Interactions
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Author : Sergey Fedoroff
language : en
Publisher: Springer
Release Date : 1993-11-30

Biology And Pathology Of Astrocyte Neuron Interactions written by Sergey Fedoroff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-11-30 with Science categories.


This volume is made up of papers presented at the Second International Altschul Symposium: Biology and Pathology of Astrocyte-Neuron Interactions. The symposium was held in Saskatoon, Canada at the University of Saskatchewn in May, 1992 in memory of Rudolf Altschul, a graduate of the University of Prague and a pioneer in the fields of the biology of the vascular and nervous systems. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The Altschul Symposia were made possible by an endowment left by Anni Altschul and by other contributions. The symposia are held biennially. One of the greatest challenges for present day scientists is to uncover the mechanisms of brain function. Although cellular anatomy of the nervous system has already been well outlined and indeed was delineated by the beginning of the century, experimental analysis of the function of the brain is relatively recent. The framework of the brain is made up of stellate cells, the astrocytes, which are interconnected by means of their processes, thus presenting a meshwork through which the neurons send their axons, accompanied by oligodendrocytes. Microglia are distributed throughout the brain.



The Biology Of Glial Cells Recent Advances


The Biology Of Glial Cells Recent Advances
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Author : Ishan Patro
language : en
Publisher: Springer Nature
Release Date : 2022-04-09

The Biology Of Glial Cells Recent Advances written by Ishan Patro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-09 with Medical categories.


This book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease. ​



Glial Cells In Health And Disease Of The Cns


Glial Cells In Health And Disease Of The Cns
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Author : Rommy von Bernhardi
language : en
Publisher: Springer
Release Date : 2016-10-06

Glial Cells In Health And Disease Of The Cns written by Rommy von Bernhardi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-06 with Medical categories.


A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.



Neuroglia Function And Pathology


Neuroglia Function And Pathology
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Author : Alexei Verkhratsky
language : en
Publisher: Elsevier
Release Date : 2023-05-12

Neuroglia Function And Pathology written by Alexei Verkhratsky and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-12 with Medical categories.


Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment. In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function. Neuroglia: Function and Pathology provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates. Single volume covering key aspects of glial cell physiology and pathology In depth overview of the history of glial cell research Comprehensive review of glial cell physiology and pathology Authoritative special chapters on the major neurological diseases Full colour throughout, with 360 illustrations