Asymmetric Cell Division In Development Differentiation And Cancer
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Asymmetric Cell Division In Development Differentiation And Cancer
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Author : Jean-Pierre Tassan
language : en
Publisher: Springer
Release Date : 2017-04-12
Asymmetric Cell Division In Development Differentiation And Cancer written by Jean-Pierre Tassan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-12 with Science categories.
This book provides readers with an overview of the frequent occurrence of asymmetric cell division. Employing a broad range of examples, it highlights how this mode of cell division constitutes the basis of multicellular organism development and how its misregulation can lead to cancer. To underline such developmental correlations, readers will for example gain insights into stem cell fate and tumor growth. In turn, subsequent chapters include descriptions of asymmetric cell division from unicellular organisms to humans in both physiological and pathological conditions. The book also illustrates the importance of this process for evolution and our need to understand the background mechanisms, offering a valuable guide not only for students in the field of developmental biology but also for experienced researchers from neighboring fields.
Asymmetric Cell Division
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Author : Alvaro Macieira-Coelho
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-21
Asymmetric Cell Division written by Alvaro Macieira-Coelho and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-21 with Science categories.
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Lung Stem Cell Behavior
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Author : Ahmed El-Hashash
language : en
Publisher: Springer
Release Date : 2018-09-03
Lung Stem Cell Behavior written by Ahmed El-Hashash and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Science categories.
This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.
Evo Devo Non Model Species In Cell And Developmental Biology
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Author : Waclaw Tworzydlo
language : en
Publisher: Springer Nature
Release Date : 2019-10-09
Evo Devo Non Model Species In Cell And Developmental Biology written by Waclaw Tworzydlo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-09 with Science categories.
Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book’s content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.
Cell Cycle In Development
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Author : Jacek Z. Kubiak
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-01
Cell Cycle In Development written by Jacek Z. Kubiak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-01 with Science categories.
This book focuses on the intersection between cell cycle regulation and embryo development. Specific modifications of the canonical cell cycle occur throughout the whole period of development and are adapted to fulfil functions coded by the developmental program. Deciphering these adaptations is essential to comprehending how living organisms develop. The aim of this book is to review the best-known modifications and adaptations of the cell cycle during development. The first chapters cover the general problems of how the cell cycle evolves, while consecutive chapters guide readers through the plethora of such phenomena. The book closes with a description of specific changes in the cell cycle of neurons in the senescent human brain. Taken together, the chapters present a panorama of species - from worms to humans - and of developmental stages - from unfertilized oocyte to aged adult.
Drug Resistance In Cancer Mechanisms And Strategies
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Author : Sameer Ullah Khan
language : en
Publisher: Springer Nature
Release Date : 2024-05-06
Drug Resistance In Cancer Mechanisms And Strategies written by Sameer Ullah Khan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-06 with Medical categories.
This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.
Cancer Stem Cells
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Author : Vinagolu K. Rajasekhar
language : en
Publisher: John Wiley & Sons
Release Date : 2014-01-27
Cancer Stem Cells written by Vinagolu K. Rajasekhar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-27 with Science categories.
Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.
Current Topics In Developmental Biology
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Author :
language : en
Publisher: Academic Press
Release Date : 2025-06-01
Current Topics In Developmental Biology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-01 with Science categories.
Fertilization and Activation of Development, Volume 162 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.Chapters in this new release include Fertilization and the fast block to polyspermy in the African Clawed Frog, Xenopus laevis: A historical perspective, The Mammalian Egg's Zona Pellucida, Fertilization, and Fertility, Function, structure, and regulation of the broadly conserved gamete membrane fusion protein, HAP2, Gamete activation for fertilization and seed development in flowering plants, Paternal contributions to mammalian zygote, and much more.Additional sections cover Ovarian follicle formation and activation, Cytoskeletal dynamics in gamete (pro)nuclear migration across flowering plants, animals, and yeast, and Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles. - Presents a comprehensive exploration of the fertilization process, including gamete interaction, fusion, and early embryonic development - Provides in-depth analysis of the molecular mechanisms underlying fertilization, sperm-egg recognition, and activation of embryonic development - Examines the key events and signaling pathways involved in activating embryonic development post-fertilization
Frontiers In Clinical Drug Research Anti Cancer Agents Volume 6
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-03-04
Frontiers In Clinical Drug Research Anti Cancer Agents Volume 6 written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-04 with Science categories.
Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The sixth volume of the book features reviews on these topics: · Immunomodulating Agents in The Treatment of Acute Myeloid Leukemia · Potential Natural Products for Prostate Cancer Management · Inhibition of Key Protein-Protein Interactions by Small Molecules for Cancer Drug Design · Efficacy of Hepatic Arterial Infusion Chemotherapy (HAIC) For Advanced Hepatocellular Carcinoma · Targeting Cancer Stem Cells: Implications in Health and Disease
The Drosophila Model In Cancer
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Author : Wu-Min Deng
language : en
Publisher: Springer Nature
Release Date : 2019-09-13
The Drosophila Model In Cancer written by Wu-Min Deng and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-13 with Medical categories.
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.