Atlas Of Liquid Biopsy
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Atlas Of Liquid Biopsy
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Author : Ludmilla Thomé Domingos Chinen
language : en
Publisher: Springer Nature
Release Date : 2021-05-31
Atlas Of Liquid Biopsy written by Ludmilla Thomé Domingos Chinen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-31 with Medical categories.
This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting hundreds of cell images from patients with various types of cancer, in many different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at clinical and research laboratories, hospitals and research centers.
Atlas Of Liquid Biopsy
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Author : Ludmilla Thomé Domingos Chinen
language : en
Publisher:
Release Date : 2021
Atlas Of Liquid Biopsy written by Ludmilla Thomé Domingos Chinen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cytodiagnosis categories.
This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of liquid biopsy began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting many cell images from patients with several types of cancer, in different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at hospitals, clinics and research centers.
Liquid Biopsy
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Author : Ilze Strumfa
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-07-10
Liquid Biopsy written by Ilze Strumfa and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-10 with Medical categories.
Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.
Tumor Liquid Biopsies
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Author : Florence Schaffner
language : en
Publisher: Springer Nature
Release Date : 2019-10-11
Tumor Liquid Biopsies written by Florence Schaffner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Medical categories.
This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.
Atlas Of Thyroid Cytopathology On Liquid Based Preparations
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Author : Rana S. Hoda
language : en
Publisher: Springer Nature
Release Date : 2019-08-31
Atlas Of Thyroid Cytopathology On Liquid Based Preparations written by Rana S. Hoda and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.
This illustrated volume serves as a handy guide to diagnostic fine needle aspiration (FNA) cytology of thyroid on liquid-based preparations (LBP). It is intended to be a ready resource to accurately diagnose thyroid lesions on LBP using key cytomorphologic features. Key cytologic differential diagnosis, gross, and histopathological correlations accompany the cytological findings. The Atlas of Thyroid Cytopathology on Liquid-Based Preparations is lavishly illustrated with color images of various thyroid diseases that should familiarize pathologists with the differences between conventional smears and LBP, and between the two commonly used LBPs. Authored by leaders in the field, this atlas provides clear, concise, and practical guidance pertaining to cytomorphology and the implications of thyroid FNA diagnoses for patient care in this era of precision medicine.
Liquid Biopsy As A Tool For Precision Oncology New Challenges To Assess Clinical Response
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Author : Gloria Ravegnini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-10
Liquid Biopsy As A Tool For Precision Oncology New Challenges To Assess Clinical Response written by Gloria Ravegnini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-10 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Liquid Biopsies In Solid Tumors
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Author : Massimo Cristofanilli
language : en
Publisher: Humana Press
Release Date : 2017-03-25
Liquid Biopsies In Solid Tumors written by Massimo Cristofanilli and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-25 with Medical categories.
This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.
Liquid Biopsy In Urogenital Cancers And Its Clinical Utility
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Author : Seyed Mohammad Kazem Aghamir
language : en
Publisher: Academic Press
Release Date : 2022-01-30
Liquid Biopsy In Urogenital Cancers And Its Clinical Utility written by Seyed Mohammad Kazem Aghamir and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-30 with Science categories.
Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers. Presents an overview on liquid biopsy techniques and their applications in cancer diagnosis Explains how to extract circulating tumor DNA, RNA and circulating tumor cells and extracellular vehicles from blood samples to identify the urology cancers, including testis, prostate, bladder and kidney Includes several images and schematic diagrams that illustrate content and facilitate its comprehension
Liquid Biopsy In Cancer Patients
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Author : Antonio Russo
language : en
Publisher: Humana Press
Release Date : 2017-07-26
Liquid Biopsy In Cancer Patients written by Antonio Russo and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-26 with Medical categories.
This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.
Liquid Biopsy
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Author : Janis Gardovskis
language : en
Publisher:
Release Date : 2019
Liquid Biopsy written by Janis Gardovskis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medicine (General) categories.
Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.