Autoimmune Liver Diseases


Autoimmune Liver Diseases
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Autoimmune Liver Disease


Autoimmune Liver Disease
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Author : James Neuberger
language : en
Publisher: John Wiley & Sons
Release Date : 2020-04-13

Autoimmune Liver Disease written by James Neuberger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Medical categories.


A practical guide to autoimmune liver diseases through pathogenesis, diagnosis, and management In Autoimmune Liver Disease Management and Clinical Practice, practitioners will learn about the current state of autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver transplantation, and learned approaches to patient management and empowerment. Expert authors in the field have come together to provide a thorough examination of autoimmune liver disease to help support clinicians assisting patients. The text provides an in-depth look at topics including: ● The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management ● The use (and misuse) of autoantibodies in diagnosis and treatment ● The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as de novo autoimmune hepatitis ● Optimal approaches to managing patients and keeping care personalised With breadth, depth and current-day relevance, Autoimmune Liver Disease sheds light on recent developments in management of liver disease for practitioners, nurses, and health care professionals.



Autoimmune Liver Disease


Autoimmune Liver Disease
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Author : H.-P. Dienes
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-07-12

Autoimmune Liver Disease written by H.-P. Dienes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-12 with Medical categories.


Autoimmune processes in the liver can cause severe damage and destruction leading to cirrhosis and liver failure. The clinical spectrum of autoimmune liver disease is very wide, and diagnostic difficulties often stand at the beginning of the patient’s medical career. While in autoimmune hepatitis immunosuppressive therapy has long been shown to be life-saving, therapeutic progress is small in primary biliary cirrhosis and questionable in primary sclerosing cholangitis. New approaches to treatment will be needed in the future, but require better understanding of the pathogenesis of the underlying disease process. This book, the proceedings of Falk Symposium 142 on 'Autoimmune Liver Disease’ held in Freiburg, Germany, on 12–13 October 2004 (Part I of the Gastroenterology Week Freiburg), describes possible mechanisms of pathogenesis, discusses diagnostic criteria and takes up controversies concerning treatment options. In view of the relatively frequent manifestation of autoimmune hepatitis in childhood in particular, paediatric aspects of autoimmune liver disease, and the role of liver transplantation, are given prominence.



Autoimmune Liver Diseases


Autoimmune Liver Diseases
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Author : Edward L. Krawitt
language : en
Publisher: Raven Press (ID)
Release Date : 1991

Autoimmune Liver Diseases written by Edward L. Krawitt and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.


With contributions from over 20 specialists, this text covers the pathogenesis, immunogenetics, pathology, immunological manifestations and diagnosis, prognosis and treatment of autoimmune chronic active hepatitis, primary biliary cirrhosis and primary schlerosing cholangitis.



Autoimmune Hepatitis


Autoimmune Hepatitis
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Author : Gideon M. Hirschfield
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-02

Autoimmune Hepatitis written by Gideon M. Hirschfield and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-02 with Medical categories.


With a focus on practical patient related issues, Autoimmune Hepatitis: A Guide for Practicing Clinicians serves as a useful practical, and much needed, resource for all those physicians presented with managing patients diagnosed with autoimmune hepatitis, both acutely and over the long term. It provides a basis for clinicians to understand the etiology of the disease, as well as special circumstances where management dilemmas often arise. Emphasis is given to providing management advice of immediate use to clinicians, something not presently offered by other larger general texts. The chapters are written by those with an expertise and training in this field and include the most up to date information. The book will be of great value to Gastroenterologists, Hepatologists, and Internists at all levels who see patients presenting with autoimmune hepatitis.



Autoimmune Liver Diseases


Autoimmune Liver Diseases
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Author : Hiromasa Ohira
language : en
Publisher: Springer
Release Date : 2014-08-21

Autoimmune Liver Diseases written by Hiromasa Ohira and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-21 with Medical categories.


Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.



Autoimmune Liver Diseases Autoimmune Hepatitis Pbc And Psc An Issue Of Clinics In Liver Disease E Book


Autoimmune Liver Diseases Autoimmune Hepatitis Pbc And Psc An Issue Of Clinics In Liver Disease E Book
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Author : David Bernstein
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-11-10

Autoimmune Liver Diseases Autoimmune Hepatitis Pbc And Psc An Issue Of Clinics In Liver Disease E Book written by David Bernstein and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-10 with Medical categories.


In this issue of Clinics in Liver Disease, guest editor Dr. David E. Bernstein brings his considerable expertise to the topic of Autoimmune Hepatitis Including PBC and PSC. The three main immune disorders that involve the liver are AIH, primary biliary cholangitis, and primary sclerosing cholangitis. As these autoimmune diseases can share symptoms, it is important for the hepatologist to have clinical knowledge of each and understand their differences and similarities. This issue addresses these variants and provides the reader with important information relating to pathology, diagnosis, and treatment. Contains 15 relevant, practice-oriented topics including autoimmune hepatitis: epidemiology, subtypes, and presentation; diagnosis of autoimmune hepatitis; treatment of autoimmune hepatitis including transplant; diagnostic tests in primary sclerosing cholangitis: serology, elastography, imaging; post-transplant management and complications of AIH, PBC, and PSC, including disease recurrence; and more. Provides in-depth clinical reviews on autoimmune hepatitis, including PBC and PSC, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.



Immunology And Liver


Immunology And Liver
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Author : M.P. Manns
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Immunology And Liver written by M.P. Manns and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


In 1992, the Falk Symposium No. 70 dealt with the topic `Immunology and Liver'. At that time basic mechanisms of immunology as well as immunopathogenetic mechanisms in viral and autoimmune liver diseases were discussed. Now, 7 years later, the Falk Symposium No. 114, held in Basel, Switzerland, October 20-21 1999 (Part I of the Basel Liver Week 1999), focused on immunology in autoimmune liver diseases. In the first section basic mechanisms of autoimmunity are presented, including the relevance of superantigens and the role of apoptosis. A further topic is the latest developments concerning animal models for autoimmune diseases. Recently the International Autoimmune Hepatitis Group newly defined and reclassified the syndrome of autoimmune hepatitis. Autoimmune hepatitis is now identified and studied in all parts of the world, including Asia and South America. A special variant of autoimmune hepatitis was identified as one organ manifestation of the autoimmune polyendocrine syndrome type 1, a genetic disease caused by mutations in a single transcription factor. Drug- and hepatitis-virus induced immune mediated liver diseases may serve as models for nonhepatic immune mediated disorders. DNA technology has increased our knowledge of the immunogenetic background of autoimmune liver diseases. Among the cholestatic immune mediated liver diseases, significant progress has been made concerning primary biliary cirrhosis, in particular regarding the identification of mitochondrial antigens and the characterisation of the immune reactions directed at them. The involvement of infectious agents in PBC as well as the definition of overlap syndromes is a particular focus for basic and clinical research in this area. Concerning the therapy of autoimmune liver diseases, corticosteroids and azathioprin remain the state of the art for autoimmune hepatitis, while bile acids have become well established in treatment of primary biliary cirrhosis as well as primary sclerosing cholangitis. New drugs in the future will include topical steroids such as budesonide and new immunosuppressive agents like mofetil/mycophenolate. Liver transplantation is the treatment of choice for end stage liver diseases; all autoimmune liver diseases are among the best candidates for liver transplantation. Hopefully, new therapeutic strategies based on the results obtained from experimental models will become everyday clinical practice in the next decade. Therefore this symposium concludes with a discussion.



Autoimmune Liver Disease


Autoimmune Liver Disease
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Author : Dr Michael Smith
language : en
Publisher:
Release Date : 2021-03-30

Autoimmune Liver Disease written by Dr Michael Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with categories.


In this book you will learn about the current state of autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver transplantation, and learned approaches to patient management and empowerment. The text provides an in-depth look at topics including: ● The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management● The use (and misuse) of autoantibodies in diagnosis and treatment● The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as de novo autoimmune hepatitis● Optimal approaches to managing patients and keeping care personalizedWith breadth, depth and current-day relevance, this book sheds light on recent developments in management of liver disease for practitioners, nurses, and health care professionals.



Immunology Of Liver Disease


Immunology Of Liver Disease
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Author : H.C. Thomas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Immunology Of Liver Disease written by H.C. Thomas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.



Autoimmune Liver Disease


Autoimmune Liver Disease
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Author : Mikio Nishioka
language : en
Publisher:
Release Date : 2000

Autoimmune Liver Disease written by Mikio Nishioka and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Autoimmune diseases categories.


Autoimmune liver disease is defined as immune-mediated chronic liver disease of unknown etiology. The forms of autoimmune liver disease include autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitits and an overlapping syndrome known as autoimmune cholangitis. These diseases were once considered to be rare. However, incidence of these diseases has increased with advanced of diagnostic techniques. During the past ten years, we have made enormous progress in understanding autoimmune mechanisms. Furthermore, new clinical and epidemiological studies have provided information that has changed our concept of autoimmune liver disease. This symposium was indeed a success due to the quality presentations by active researchers in the world.