Autophagy In Autoimmunity
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Autophagy In Autoimmunity
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Author : Xu-jie Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2019-05-15
Autophagy In Autoimmunity written by Xu-jie Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with categories.
Autophagy Networks In Inflammation
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Author : Maria Chiara Maiuri
language : en
Publisher: Springer
Release Date : 2016-08-17
Autophagy Networks In Inflammation written by Maria Chiara Maiuri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-17 with Medical categories.
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
Apoptosis And Its Relevance To Autoimmunity
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Author : Keith B. Elkon
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2006
Apoptosis And Its Relevance To Autoimmunity written by Keith B. Elkon and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of
Autoimmunity
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Author : Katerina Chatzidionysiou
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-06-17
Autoimmunity written by Katerina Chatzidionysiou and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-17 with Medical categories.
Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.
Autophagy
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Author : Eun-Kyeong Jo
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-07-29
Autophagy written by Eun-Kyeong Jo and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-29 with Medical categories.
Innate immune responses provide the first line of defense against invading pathogens or damaged self-molecules. However, both dysregulation and hyperactivation of immune responses are linked to inflammatory or autoimmune diseases. Autophagy is a component of primary host defense that mediates elimination of pathogens, particularly intracellular microbes. Recent advances have shown that autophagy plays an important role in the regulation of inflammation, thus providing new insights into the relationship between autophagy and inflammation. During innate immune responses, nuclear factor-κB signaling plays an important role in regulation of the autophagy pathway. Two key energy/growth sensors, the AMP-activated protein kinase and the mammalian target of rapamycin, play important roles in the autophagy-regulated signaling network connected with inflammation. Abnormalities or defects in autophagy appear to lead to pathologic inflammatory status with defective microbial killing, as in cases of immunopathologic responses in Crohn’s disease, lung inflammation, sepsis, or other inflammatory diseases. Furthermore, basal autophagy can play an important dual role in the regulation of inflammasome activation, thus shaping overall immune homeostasis, and in the unconventional secretion of a leaderless cytokine interleukin-1β. Numerous human pathologies and diseases related to inflammasome activation are impacted by defective or dysregulated autophagy. In this overview, we describe recent advances in the roles of autophagy in the regulation of chronic inflammatory conditions and pathological reactions in autoimmune diseases.
Strategies For Modulating T Cell Responses In Autoimmunity And Infection
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Author : Maria Florencia Quiroga
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-13
Strategies For Modulating T Cell Responses In Autoimmunity And Infection written by Maria Florencia Quiroga and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-13 with categories.
Mosaic Of Autoimmunity
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Author : Carlo Perricone
language : en
Publisher: Academic Press
Release Date : 2019-02-15
Mosaic Of Autoimmunity written by Carlo Perricone and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-15 with Medical categories.
The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications
Jump Start Autophagy
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Author : Melissa Mayer
language : en
Publisher: Simon and Schuster
Release Date : 2019-10-22
Jump Start Autophagy written by Melissa Mayer and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-22 with Health & Fitness categories.
Harness your body’s natural cell-rejuvenating process for amazing health benefits To maintain good health, it is vital that your body’s natural detoxing process of cleaning out damaged cells and regenerating new ones, known as autophagy, is working well. Dysfunctional cellular processes can cause all kinds of serious issues, from premature aging to cancer. On the other hand, a healthy autophagy process can reduce inflammation, prevent skin issues, boost metabolism, and even heal autoimmune issues. Jump Start Autophagy will give you all the tools you need to hack your cells for a longer, healthier life. The book will walk you through the science of autophagy, how it works, and why our bodies need it. It will break down the different ways our bodies are signaled to kick start autophagy; and, best of all, show you concrete examples, activities, and methods to push your own body into autophagy to achieve healthier skin, boost your metabolism, heal inflammation, and so much more.
The Role Of Immunometabolism In Autoimmune Mediated And Autoinflammatory Disorders
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Author : Valentina Pucino
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-25
The Role Of Immunometabolism In Autoimmune Mediated And Autoinflammatory Disorders written by Valentina Pucino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-25 with Medical categories.
Translational Autoimmunity Volume 1
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Author : Nima Rezaei
language : en
Publisher: Academic Press
Release Date : 2021-10-22
Translational Autoimmunity Volume 1 written by Nima Rezaei and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-22 with Medical categories.
Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions. Includes coverage of basic immunology, the clinical aspects of autoimmunity, and translational immunology studies in autoimmunity Presents key concepts supported by a systematic appraisal of the most recent evidence Assists students at all the academic levels while also being applicable to scientists who work with autoimmunity Designed for learning, teaching, review, testing, practice and research