Autophagy In Tumor And Tumor Microenvironment
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Autophagy And Cancer
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Author : Hong-Gang Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-30
Autophagy And Cancer written by Hong-Gang Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-30 with Medical categories.
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
Autophagy In Tumor And Tumor Microenvironment
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Author : Sujit Kumar Bhutia
language : en
Publisher: Springer Nature
Release Date : 2020-10-24
Autophagy In Tumor And Tumor Microenvironment written by Sujit Kumar Bhutia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-24 with Medical categories.
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Cell Death
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Author : Tobias Ntuli
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-12-16
Cell Death written by Tobias Ntuli and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-16 with Science categories.
This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.
Self Eating On Demand Autophagy In Cancer And Cancer Therapy
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Author : Patrizia Agostinis
language : en
Publisher: Frontiers Media SA
Release Date : 2018-02-19
Self Eating On Demand Autophagy In Cancer And Cancer Therapy written by Patrizia Agostinis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-19 with categories.
Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.
Autophagy In Immune Response Impact On Cancer Immunotherapy
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Author : Salem Chouaib
language : en
Publisher: Academic Press
Release Date : 2020-05-11
Autophagy In Immune Response Impact On Cancer Immunotherapy written by Salem Chouaib and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-11 with Science categories.
Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.
Cell Cycle Control
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Author : Michele Pagano
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-06-08
Cell Cycle Control written by Michele Pagano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-06-08 with Medical categories.
Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.
Oxford Textbook Of Oncology
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Author : David J. Kerr
language : en
Publisher: Oxford University Press
Release Date : 2016
Oxford Textbook Of Oncology written by David J. Kerr and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Written by internationally recognized key opinion leaders in all of the oncology sub-disciplines and covering all aspects of the field, the Oxford Textbook of Oncology, Third Edition reflects current best practice and represents a modern approach to managing the cancer patient. This is a definitive resource for oncologists of all varieties.
Targeting Autophagy In Cancer Therapy
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Author : Jin-Ming Yang
language : en
Publisher: Springer
Release Date : 2016-09-02
Targeting Autophagy In Cancer Therapy written by Jin-Ming Yang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-02 with Medical categories.
This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research. This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
New Roles Of Autophagy Pathways In Cancer
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Author : Daniel Hector Grasso
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-10
New Roles Of Autophagy Pathways In Cancer written by Daniel Hector Grasso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-10 with Science categories.