Axon Growth And Regeneration
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Axon Growth And Regeneration Part 2
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Axon Growth And Regeneration Part 2 written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Axon Growth And Regeneration Part 1
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Axon Growth And Regeneration Part 1 written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding Axon Growth and Regeneration. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Axon Growth And Regeneration
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Author : Andrew J. Murray
language : en
Publisher: Humana Press
Release Date : 2014-05-17
Axon Growth And Regeneration written by Andrew J. Murray and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-17 with Medical categories.
Axon Growth and Regeneration: Methods and Protocols brings together a diverse set of techniques for the study of the mechanisms underlying central nervous system axon growth, consequently providing a resource that will aid in the development of repair strategies. After an introductory section, this detailed volume continues with sections focusing on axon growth in vitro, providing a range of protocols that can be used to examine intracellular signalling pathways, axonal responses to extracellular factors and methods for quantifying outgrowth. The next section provides protocols for inducing experimental injury in vivo as well as some highly promising protocols for promoting regeneration, which segues into the final section highlighting a series of protocols that can be used to monitor the extent of axon regeneration in vivo, ranging from tract tracing to in vivo imaging and functional recovery. As a book in the Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and reliable, Axon Growth and Regeneration: Methods and Protocols aims to serve researchers studying axon regeneration with a significant set of diverse tools, vital for moving on to the next generation of exciting new discoveries in the field.
Axonal Transport In Neuronal Growth And Regeneration
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Author : John Elam
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Axonal Transport In Neuronal Growth And Regeneration written by John Elam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Over the past several years, the pace of research on the control of axonal growth has increased at a remarkable rate, and this activity is reflected in a growing literature dealing with various aspects of axonal growth and regener ation. It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth processes. Through the cooperation of the senior editors of this series, we have been given the opportunity to bring such a focus to the current volume. We wish to acknowledge that the contributing authors attended a confer ence on "The Role of Axonal Transport in Neuronal Growth and Regenera tion" held in Tallahassee, Florida in March, 1983, sponsored by the Psycho biology Research Center of the Florida State University. It is our hope that many of the perceptions and insights expressed in these chapters resulted from our interactions.
Molecular Mechanisms Of Axon Growth And Regeneration
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Author : Dana Watt
language : en
Publisher:
Release Date : 2015
Molecular Mechanisms Of Axon Growth And Regeneration written by Dana Watt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Electronic dissertations categories.
Neurons are cells with unique and extremely polarized morphologies. The axon allows communication between the cell soma and the distantly located synaptic terminal and can extend up to one meter in humans. This exceptional cellular structure therefore has specialized biological processes dedicated to its growth, maintenance and regeneration. The structure that carries out axon elongation during development and regeneration is the growth cone, which features a cytoskeletal structure that is both highly dynamic yet consistent in overall organization. The growth cone coordinates a leading edge of dynamic actin with the microtubules of the growing axon, enabling directed outgrowth while maintaining the structural integrity of the axon. In the axon, microtubules are oriented uniformly with their plus-ends facing away from the cell body, providing directionality for cargo transport streams. Axonal transport is critical during growth and after the axon has reached its target to ensure proper distribution of organelles and other necessary components of the axonal biology machinery. Axon transport is especially important because the axon is capable of independently carrying out tasks ranging from protein synthesis to synaptic transmission. Therefore a thorough understanding of microtubule biology and axon transport is critical for understanding how axons grow during development and regeneration. I first investigated the role of a neuron-specific molecular motor adaptor, JIP3, in axon elongation. JIP3 had been previously demonstrated to bind both the anterograde motor kinesin-1 and the retrograde motor complex dynein/dynactin, generating cargo-specific directional transport in the axon. Furthermore, our lab had also demonstrated that JIP3 was capable of binding directly and activating dimeric kinesin heavy chain (KHC) for motility. While the function of dimeric KHC is still debated, tetrameric kinesin-1 is known as the primary anterograde motor in axons. I therefore investigated the role of JIP3 in regulating tetrameric kinesin-1 motility, and the functional significance of this interaction in axons. I used a total internal reflection fluorescence (TIRF)-based single molecule imaging assay to demonstrate that JIP3 binds to the kinesin-1 tetramer in at least a 2:1 ratio. I also used this TIRF assay to show that JIP3 binding to the cargo-adapting kinesin light chain (KLC) activated tetrameric kinesin-1 for microtubule binding, while JIP3 binding to KHC activated tetrameric kinesin-1 motility along microtubules. Furthermore, while the JIP3/KLC interaction is dispensable for axon growth and regeneration in neurons in vitro, the JIP3/KHC interaction is necessary for both these activities. This work demonstrated that a single molecule can activate tetrameric kinesin-1 for microtubule binding and motility. Furthermore, this work demonstrated that regulation of molecular motor activity supports axon growth and regeneration. I next investigated the small GTPase Ran and its role in axon elongation. Ran is best known for its canonical function as a nuclear transport protein, but it can also stabilize microtubules during mitotic spindle formation and is located in the axon. While Ran has a proposed role in regulating a retrograde injury signaling complex in adult axons, it is unknown whether Ran also regulates cytoskeletal dynamics in developing axons. I used Ran knockdown to demonstrate that Ran promotes axon elongation on growth-promoting substrates, and restricts axon elongation on growth-inhibiting substrates. This effect is at least partially mediated by microtubule dynamics, as microtubule imaging using a cell-permeable pan-tubulin marker showed decreased microtubule dynamics in Ran knockdown cells on growth-promoting substrates. Furthermore, I demonstrated that a Ran activating protein, RanBP10, is enriched in growth cones and promotes axon elongation, and that both of these phenomena are Ran-dependent. This work raises the exciting possibility that Ran controls microtubule dynamics in the growth cone, distinct from its canonical role in nucleocytoplasmic trafficking.
Axon Growth And Regeneration In The Mammalian Nervous System
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Author : Derryck Alan Shewan
language : en
Publisher:
Release Date : 1995
Axon Growth And Regeneration In The Mammalian Nervous System written by Derryck Alan Shewan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Axon Growth And Regeneration
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Author : Jeffrey L. Goldberg
language : en
Publisher: Academic Press
Release Date : 2012
Axon Growth And Regeneration written by Jeffrey L. Goldberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Further Genetic Identification Of Genes And Pathways Associated With Axon Growth And Regeneration
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Author : Patricia Carter
language : en
Publisher:
Release Date : 2012
Further Genetic Identification Of Genes And Pathways Associated With Axon Growth And Regeneration written by Patricia Carter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
To understand how to fix damages to the central nervous system, the genes and pathways associated with axon growth and regeneration must be determined. Although significant progress has been made in understanding axon growth and regeneration in vitro, demonstrating in vivo roles requires intense effort. My project consisted of three goals that would help us gain better understanding of axon growth and regeneration. The project was performed using the model animal Caenorhabditis elegans. The first goal of this project was to test the in vivo interactions among genes known to be moderately involved in axon regeneration via double mutants. We found that some of the genes appear to work together, while others do not. The second goal was to test genes previously determined to have significant affects on PLM axon regeneration to see if their role is conserved in the PDE, a different neuron type. We found that for axon regeneration, gene function do not appear to be conserved in the PDE. The last goal was to determine the function of not previously tested genes on axon growth and regeneration. Of the genes tested, some showed affects on axon growth or regeneration alone, while some showed affects in both. Overall, we have determined pathways and function conservation of genes known to be involved in axon growth and regeneration, while also determining the functions of new genes. Further studies need to be done to determine genetic interactions of the genes with the pathways that guide proper axon growth and regeneration.
Axon Growth Injury And Regeneration In The Fly Brain
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Author : Maarten Leyssen
language : en
Publisher: Leuven University Press
Release Date : 2006
Axon Growth Injury And Regeneration In The Fly Brain written by Maarten Leyssen and has been published by Leuven University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Axons categories.
How Reggies Regulate Regeneration And Axon Growth
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Author : Claudia Stürmer
language : en
Publisher:
Release Date : 2012
How Reggies Regulate Regeneration And Axon Growth written by Claudia Stürmer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.