Bacterial Signal Transduction Networks And Drug Targets
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Bacterial Signal Transduction Networks And Drug Targets
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Author : Ryutaro Utsumi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-05
Bacterial Signal Transduction Networks And Drug Targets written by Ryutaro Utsumi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-05 with Medical categories.
This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.
A First Course In Systems Biology
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Author : Eberhard Voit
language : en
Publisher: Taylor & Francis
Release Date : 2025-01-20
A First Course In Systems Biology written by Eberhard Voit and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-20 with Science categories.
A First Course in Systems Biology, Third Edition is an introduction to the growing field of systems biology for advanced undergraduates and graduate students. Its focus is the design and analysis of computational models and their applications to diverse biomedical phenomena, from simple networks and kinetics to complex pathway systems, signal transduction, personalized medicine, and interacting populations. The book begins with the fundamentals of computational modeling, then reviews features of the molecular inventories that bring biological systems to life and ends with case studies that reflect some of the frontiers in systems biology. In this way, the First Course provides the reader with a comprehensive background and with access to methods for executing standard tasks of biomedical systems analysis, exposure to the modern literature, and a foundation for launching into specialized projects that address biomedical questions with theoretical and computational means. This third edition has been thoroughly updated. It provides an introduction to agent-based and multiscale modeling, a deeper account of biological design principles, and the optimization of metabolic flux distributions. This edition also discusses novel topics of synthetic biology, personalized medicine, and virtual clinical trials that are just emerging on the horizon of this field.
Stress And Environmental Regulation Of Gene Expression And Adaptation In Bacteria
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Author : Frans J. de Bruijn
language : en
Publisher: John Wiley & Sons
Release Date : 2016-07-13
Stress And Environmental Regulation Of Gene Expression And Adaptation In Bacteria written by Frans J. de Bruijn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-13 with Science categories.
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Design Of Nanostructures For Versatile Therapeutic Applications
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Author : Alexandru Mihai Grumezescu
language : en
Publisher: William Andrew
Release Date : 2018-02-03
Design Of Nanostructures For Versatile Therapeutic Applications written by Alexandru Mihai Grumezescu and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-03 with Science categories.
Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry. - Assesses the most recently developed nanostructures that have potential antimicrobial properties, explaining their novel mechanical aspects - Shows how nanoantibiotics can be used to more effectively treat disease - Provides a cogent summary of recent developments in nanoantimicrobial discovery, allowing readers to quickly familiarize themselves with the topic
Pseudomonas
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Author : Juan L. Ramos
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Pseudomonas written by Juan L. Ramos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Science categories.
Paris is a cosmopolitan city where roaring life, wonderful museums and excellent science can be found. It was during the XI IUMS conference held in this city that the Pseudomonas book series was ?rst envisaged. On the ?rst row of the auditorium sat a group of outstanding scientists in the ?eld, who after devoting much of their valuable time, contributed in an exceptional manner to the ?rst three volumes of the series, which saw the light simultaneously. The volumes were grouped under the generic titles of “Vol. I. Pseudomonas: Genomics, Life Style and Molecular Architecture”, Vol. II. Pseudomonas: Virulence and gene regulation; Vol. III. Pseudomonas: Biosynthesis of Macromolecules and Molecular Metabolism. Soon after the completion of the ?rst three volumes, a rapid search for ar- cles containing the word Pseudomonas in the title in the last 10 years produced over 6,000 articles! Consequently, not all possible topics relevant to this genus were covered in the three ?rst volumes. Since then two other volumes were p- lished: Pseudomonas volume IV edited by Roger Levesque and Juan L. Ramos that came to being with the intention of collecting some of the most relevant emerging new issues that had not been dealt with in the three previous volumes. This v- ume was arranged after the Pseudomonas meeting organized by Roger Levesque in Quebec (Canada). It dealt with various topics grouped under a common heading: “Pseudomonas: Molecular Biology of Emerging Issues”.
Rhizosphere Microbes
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Author : Sushil Kumar Sharma
language : en
Publisher: Springer Nature
Release Date : 2021-01-20
Rhizosphere Microbes written by Sushil Kumar Sharma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Technology & Engineering categories.
Plants create a dynamic micro-biosphere in the soil, around the roots, called as ‘rhizosphere’, which harbors diverse number of microorganisms for sustaining their growth and development. A soil with diverse and multi-traits microbial communities is considered healthy to enhance crop productivity. In the last decades, rhizosphere biology has gained attention due to unraveling of new mechanisms, processes and molecules in the rhizosphere that contributes towards the promotion of plant productivity. The rhizospheric microbes and associated processes are being utilized for harnessing potential of soils in effective and sustainable functioning in the agro-ecosystems. Broadly, the book discusses rhizospheric microbes and their role in modulating functions of soil and crop plant. Specifically, it highlights conventional and modern aspects of rhizosphere microbes such as – microbiome in the rhizosphere, microbes as an indicator and promoter of soil health, rhizosphere microbes as biofertilizer, biostimulator and biofortifyer, microbial signaling in the rhizosphere, recent tools in deciphering rhizobiome, and regulatory mechanisms for commercialization of biofertilizer, biopesticide and biostimulator. The book is useful for agriculture scientist, biotechnologist, plant pathologist, mycologist, and microbiologist, farming community, scientist of R&D organization, as well as teaching community, researcher and student and policy maker.
Prokaryotic Systems Biology
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Author : Nevan J. Krogan, PhD
language : en
Publisher: Springer
Release Date : 2015-11-30
Prokaryotic Systems Biology written by Nevan J. Krogan, PhD and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-30 with Science categories.
This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data.
Network Pharmacology And Traditional Medicine Setting The New Standards By Combining In Silico And Experimental Work
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Author : Shao Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-24
Network Pharmacology And Traditional Medicine Setting The New Standards By Combining In Silico And Experimental Work written by Shao Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-24 with Science categories.
Bioscience Biotechnology And Biochemistry
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Author :
language : en
Publisher:
Release Date : 2010
Bioscience Biotechnology And Biochemistry written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Biochemistry categories.
Biological Networks
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Author :
language : en
Publisher:
Release Date :
Biological Networks written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.