Basic Biology And Current Understanding Of Skeletal Muscle
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Basic Biology And Current Understanding Of Skeletal Muscle
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Author : Kunihiro Sakuma
language : en
Publisher: Nova Biomedical Books
Release Date : 2013
Basic Biology And Current Understanding Of Skeletal Muscle written by Kunihiro Sakuma and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Muscles categories.
Skeletal muscle is a highly plastic tissue that constitutes approximately thirty percent of total body mass and adapts rapidly to changing functional demands. Skeletal muscle is not only the generator of force production, but also plays a crucial role in whole body metabolism and energy consumption. In this book, leading experts in the area of exercise biochemistry and molecular biology in skeletal muscle provide an up-to-date view of the molecular basis of various adaptations of skeletal muscle, with emphasis on new biological concepts (muscle stem cells, muscle steroidogenesis, etc). This book deals with the recent intriguing role of heat shock protein (HSP), AMPK and reactive oxygen species (ROS) for muscle morphology, function and metabolism. Discussed also is the molecular mechanism for protein metabolism and therapeutic application for sarcopenia. The deeper understanding of the signal transduction and modification in skeletal muscle will develop new therapeutic strategies for preventing physical disability and increased risk of morbidity/mortality due to the loss of muscle mass.
Basic Biology And Current Understanding Of Skeletal Muscle
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Author : Kunihiro Sakuma
language : en
Publisher:
Release Date : 2013
Basic Biology And Current Understanding Of Skeletal Muscle written by Kunihiro Sakuma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Skeletal muscle is a highly plastic tissue that constitutes approximately thirty percent of total body mass and adapts rapidly to changing functional demands. Skeletal muscle is not only the generator of force production, but also plays a crucial role in whole body metabolism and energy consumption. In this book, leading experts in the area of exercise biochemistry and molecular biology in skeletal muscle provide an up-to-date view of the molecular basis of various adaptations of skeletal muscle, with emphasis on new biological concepts (muscle stem cells, muscle steroidogenesis, etc). This book deals with the recent intriguing role of heat shock protein (HSP), AMPK and reactive oxygen species (ROS) for muscle morphology, function and metabolism. Discussed also is the molecular mechanism for protein metabolism and therapeutic application for sarcopenia. The deeper understanding of the signal transduction and modification in skeletal muscle will develop new therapeutic strategies for preventing physical disability and increased risk of morbidity/mortality due to the loss of muscle mass.
Omics Approaches To Understanding Muscle Biology
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Author : Jatin George Burniston
language : en
Publisher: Springer Nature
Release Date : 2019-11-05
Omics Approaches To Understanding Muscle Biology written by Jatin George Burniston and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-05 with Medical categories.
This book is a collection of principles and current practices in omics research, applied to skeletal muscle physiology and disorders. The various sections are categorized according to the level of biological organization, namely, genomics (DNA), transcriptomics (RNA), proteomics (protein), and metabolomics (metabolite). With skeletal muscle as the unifying theme, and featuring contributions from leading experts in this traditional field of research, it highlights the importance of skeletal muscle tissue in human development, health and successful ageing. It also discusses other fascinating topics like developmental biology, muscular dystrophies, exercise, insulin resistance and atrophy due to disuse, ageing or other muscle diseases, conveying the vast opportunities for generating new hypotheses as well as testing existing hypotheses by combining high-throughput techniques with proper experiment designs, bioinformatics and statistical analyses. Presenting the latest research techniques, this book is a valuable resource for the physiology community, particularly researchers and grad students who want to explore the new opportunities for omics technologies in basic physiology research.
Muscle Cells
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Author : Mani T. Valarmathi
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-01-22
Muscle Cells written by Mani T. Valarmathi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-22 with Science categories.
The three different types of muscle tissue found in the animal kingdom are cardiac, skeletal, and smooth. The muscle cells are not only complex but also fascinating. In recent years there has been substantial advances in our understanding of muscle cell biology, especially in areas of molecular anatomy, basic physiology, understanding disease mechanisms, and therapeutic targets. Consequently, this book mainly focuses not only on the biology of myocytes, but also on all-encompassing disciplines pertaining to muscle tissue, such as fundamental physiology, molecular mechanisms of diseases, muscle regeneration, etc. for all three types of muscle, namely, skeletal, cardiac, and smooth muscle. As a result, the goal of this book is to consolidate the recent advances in the area of muscle biology/diseases/regeneration covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in muscle cell biology, exercise physiology/science, stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough knowledge pertaining to recent advances in muscle biology in the context of health and disease.
Skeletal Muscle Circulation
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Author : Ronald J. Korthuis
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
Skeletal Muscle Circulation written by Ronald J. Korthuis and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Skeletal Muscle Circulation
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Author : Ronald Korthuis
language : en
Publisher: Biota Publishing
Release Date : 2011-06-01
Skeletal Muscle Circulation written by Ronald Korthuis and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-01 with Science categories.
The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References
Mechanism Of Muscular Contraction
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Author : Jack A. Rall
language : en
Publisher: Springer
Release Date : 2014-10-21
Mechanism Of Muscular Contraction written by Jack A. Rall and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-21 with Medical categories.
This book describes the evolution of ideas relating to the mechanism of muscular contraction since the discovery of sliding filaments in 1954. An amazing variety of experimental techniques have been employed to investigate the mechanism of muscular contraction and relaxation. Some background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. Controversies in the muscle field are discussed along with some missed opportunities and false trails. The pathway to ATP and the high energy phosphate bond will be discussed, as well as the discovery of myosin, contraction coupling and the emergence of cell and molecular biology in the muscle field. Numerous figures from original papers are also included for readers to see the data that led to important conclusions. This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.
Current Researches In Skeletal Muscle
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Author : Joel Reynolds
language : en
Publisher:
Release Date : 2015-03-27
Current Researches In Skeletal Muscle written by Joel Reynolds and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-27 with Muscles categories.
This book, written by renowned experts, provides a comprehensive knowledge of skeletal muscles. The book presents a broad variety of subjects connected to skeletal muscle morphology and its functions. It deals with the procedure of myogenesis and the renewal of skeletal muscle, and the morphological and functional changes due to the effect of exercise or misuse. Execution of molecular biology methods in the investigations reveals a fresh point of view in the perception of skeletal muscle complications. The deeper examination of the neuromuscular signal transduction and alteration offers steadier basis for medical interventions. This book intends to help its readers in comprehending the subject in a better way.
Muscle Biophysics
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Author : Rassier Dilson J.E
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-08
Muscle Biophysics written by Rassier Dilson J.E and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-08 with Science categories.
Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.