Basic Immunology Functions And Disorders Of The Immune System 6e Sae E Book
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Basic Immunology Functions And Disorders Of The Immune System 6e Sae E Book
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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-06-28
Basic Immunology Functions And Disorders Of The Immune System 6e Sae E Book written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-28 with Medical categories.
Basic Immunology: Functions and Disorders of the Immune System, 6e: SAE-E-book
Construction And Utilization Of Digital Twins For Personalized Therapeutic Predictions
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Author : Samuel Schäfer
language : en
Publisher: Linköping University Electronic Press
Release Date : 2024-10-18
Construction And Utilization Of Digital Twins For Personalized Therapeutic Predictions written by Samuel Schäfer and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-18 with categories.
Modern healthcare faces a significant challenge, namely that 25-70% of patients with common diseases do not benefit from standard treatments despite the availability of over 13,000 drugs registered in DrugBank. This discrepancy is likely due to these diseases' complex and heterogeneous molecular nature rather than a lack of therapeutic options. Emerging technologies have revealed the immense molecular complexity underlying common diseases. For instance, singlecell RNA sequencing (scRNA-seq) has demonstrated altered gene interactions in and across multiple cell types in numerous tissues. Furthermore, these technologies have revealed vast molecular differences between patients with the same diagnosis. There is a wide gap between this complexity and the current diagnostic and therapeutic approaches. Aim: To bring personalized medicine one step closer to the clinic; this thesis focuses on developing digital disease models that can capture the molecular biological complexity of disease in individual patients. We aim to harness these disease models to identify optimal treatments for each individual patient. Paper I: We started by exploring the usefulness of OMIC-based approaches for diagnostic and therapeutic predictions. Utilizing a single-cell RNA-sequenced mouse model of antigen-induced arthritis, we aimed to prioritize cell types and therapeutic targets. Initial pathway enrichment analyses did not yield relevant prioritization, prompting an investigation into network-based approaches. Multi-cellular disease models (MCDMs) for AIA and human rheumatoid arthritis were constructed, incorporating predicted cell type interactions. Centrality analysis indicated that these interactions could quantify a cell type’s relative importance in disease pathogenesis. We hypothesized that transcriptomic alterations in central cell types might reflect the MCDM, serving as potential diagnostic markers. An analysis of CD4+ T cells from patients with 13 different inflammatory diseases and healthy controls demonstrated that these profiles could discriminate between healthy and diseased states and among diseases. Furthermore, a network-based approach identified drugs targeting disease- associated changes common to multiple inflammatory diseases. Notably, one of these drugs, bezafibrate, successfully dampened inflammation in the AIA mouse model. Paper II: Building on the insights from Paper I, we investigated multicellular network models (MNMs) with time as an additional dimension. Using seasonal allergic rhinitis (SAR) as a disease model, we analyzed time-series scRNAseq data to construct MNMs of inflammatory diseases. We identified thousands of disease-associated expression changes across multiple cell types, varying at different disease stages. Notably, upstream regulators (URs) of these changes were also stage-dependent and multidirectional. To prioritize URs for drug discovery, we focused on those causing significant expression changes in multiple cell types across all time points. This strategy was validated through similar analyses of atopic dermatitis, ulcerative colitis, and Crohn’s disease, confirming that ranked URs aligned with the efficacy of existing drugs targeting the URs in the respective diseases. Furthermore, experimental validation included targeting the top-ranked regulatory gene in SAR, which was more effective than previously discovered IL4 inhibition. Paper III: While Paper I established the use of transcriptomic data for therapeutic predictions, it focused on overlapping disease-related changes across multiple inflammatory diseases and considered transcriptomic changes in only one cell type. Paper II indicated a potential benefit in UR prioritization in numerous cell types. However, it yielded heterogeneous results and was limited by the fact that few drugs directly target URs. Neither of these approaches was feasible for individualized drug predictions. Drawing on previous insights by us and others, we next aimed to develop digital disease models for individual patients, termed digital twins, with the capability for drug efficacy screening. We proposed scDrugPrio, a strategy utilizing single-cell scRNA-sequencing-based multicellular disease models incorporating key biological and pharmacological properties, such as varying gene expression levels, varying gene interactions within and between cell types, and drug effect. scDrugPrio was constructed based on a mouse model of arthritis and validated by improved precision/recall for known drugs and in vitro studies of predicted drugs that were FDA approved for other diseases and had not yet been tried in rheumatoid arthritis or mouse arthritis. For validation, scDrugPrio was applied to human multiple sclerosis as well as Crohn’s disease data that included tissue samples from healthy and sick tissue of all patients; scDrugPrio was able to identify relevant treatments for individual patients and could distinguish anti-TNF responders from non-responders. Conclusion: This thesis demonstrates a framework for constructing digital disease models for personalized therapeutic predictions that might hold potential for better clinical treatment decisions. By leveraging advanced genome-wide analyses and network-based approaches, we may enhance the precision and efficacy of treatments for immune-mediated inflammatory diseases, bringing personalized medicine closer to clinical reality.
The Mapping Between Traditional Chinese Medicine And Signaling Molecules
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Author : Yang Liu
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2022-06-28
The Mapping Between Traditional Chinese Medicine And Signaling Molecules written by Yang Liu and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-28 with Medical categories.
The fundamental molecules in the human body are sodium, calcium, and potassium, while the vital substances of traditional Chinese medicine (TCM) are Qi, Yang Qi, and Yin Qi. This book identifies the mappings between 48 TCM vital substances and signaling molecules. TCM practitioners have proven successful in alleviating the symptoms of a wide range of conditions from arthritis to diabetes. By applying these mappings, this book thoroughly explores these claims and succinctly explains the molecular mechanism behind the practice. The communication and mutual support between eastern and western medicines would provide a thorough understanding of human physiology and enable more effective treatment of abnormal or disease states.
Sa L K Bak M Hizmetlerinde Enfeksiyonlar N Kontrol Ve Nlenmesi
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Author : Hanefi Cem GÜL
language : tr
Publisher: Akademisyen Kitabevi
Release Date : 2022-06-16
Sa L K Bak M Hizmetlerinde Enfeksiyonlar N Kontrol Ve Nlenmesi written by Hanefi Cem GÜL and has been published by Akademisyen Kitabevi this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-16 with Medical categories.
Basic Immunology
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Author : Abul K. Abbas
language : en
Publisher:
Release Date : 2020
Basic Immunology written by Abul K. Abbas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Immune system categories.
Basic Immunology
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Author : Abul K. Abbas
language : en
Publisher:
Release Date : 2019-04-24
Basic Immunology written by Abul K. Abbas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-24 with Immunity categories.
The Times Index
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Author :
language : en
Publisher:
Release Date : 1996
The Times Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Times (London, England) categories.
Indexes the Times, Sunday times and magazine, Times literary supplement, Times educational supplement, Times educational supplement Scotland, and the Times higher education supplement.
Basic Immunology
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Author : Abul K. Abbas
language : en
Publisher:
Release Date : 2021
Basic Immunology written by Abul K. Abbas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Allergy categories.
Basic Immunology Functions And Disorders Of The Immune System First South Asia Edition E Book
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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-01-20
Basic Immunology Functions And Disorders Of The Immune System First South Asia Edition E Book written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-20 with Medical categories.
In this edition of Basic Immunology, the authors continue to deliver a clear, modern introduction to immunology, making this the obvious choice for today's busy students. Their experience as teachers, course directors, and lecturers helps them to distill the core information required to understand this complex field. Through the use of high-quality illustrations, relevant clinical cases, and concise, focused text, it's a perfectly accessible introduction to the workings of the human immune system, with an emphasis on clinical relevance. - Concise, clinically focused content is logically organized by mechanism for efficient mastery of the material. - Features an appendix of clinical cases and CD molecules. - Includes numerous full-color illustrations, useful tables, and chapter outlines. - Focus questions within each chapter are ideal for self-assessment and review. - Key points bolded throughout the text make it easy to locate important information.
Basic Immunology Updated Edition E Book
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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2010-01-26
Basic Immunology Updated Edition E Book written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-26 with Medical categories.
This updated 3rd edition of Basic Immunology provides a readable and concise introduction to the workings of the human immune system, with emphasis on clinical relevance. The format makes learning easy with short, easy-to-read chapters, color tables, key point summaries, and review questions in every chapter. You’ll get the latest coverage on regulatory T cells, biology of the Th17 subset of CD4+ T cells, and more. The full-color artwork, comprehensive glossary, and clinical cases are just some of the features that reinforce and test your understanding of how the immune system functions. Covers the most up-to-date immunology information including regulatory T cells, and biology of the Th17 subset of CD4+ T cells to keep you completely current. Relates basic science to clinical disorders through clinical cases for better application in a real-world setting. Provides a full Glossary to keep you on the cutting edge of immunologic terminology. Includes appendices summarizing the features of CD Molecules, a handy Glossary, and Clinical Cases that test your understanding of how the immune system functions in health and disease. Presents beautiful full-color artwork for enhanced visual learning.