Basic Immunology Functions And Disorders Of The Immune System 6e Sae E Book
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Basic Immunology Functions And Disorders Of The Immune System 6e Sae E Book
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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-06-28
Basic Immunology Functions And Disorders Of The Immune System 6e Sae E Book written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-28 with Medical categories.
Basic Immunology: Functions and Disorders of the Immune System, 6e: SAE-E-book
Construction And Utilization Of Digital Twins For Personalized Therapeutic Predictions
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Author : Samuel Schäfer
language : en
Publisher: Linköping University Electronic Press
Release Date : 2024-10-18
Construction And Utilization Of Digital Twins For Personalized Therapeutic Predictions written by Samuel Schäfer and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-18 with categories.
Modern healthcare faces a significant challenge, namely that 25-70% of patients with common diseases do not benefit from standard treatments despite the availability of over 13,000 drugs registered in DrugBank. This discrepancy is likely due to these diseases' complex and heterogeneous molecular nature rather than a lack of therapeutic options. Emerging technologies have revealed the immense molecular complexity underlying common diseases. For instance, singlecell RNA sequencing (scRNA-seq) has demonstrated altered gene interactions in and across multiple cell types in numerous tissues. Furthermore, these technologies have revealed vast molecular differences between patients with the same diagnosis. There is a wide gap between this complexity and the current diagnostic and therapeutic approaches. Aim: To bring personalized medicine one step closer to the clinic; this thesis focuses on developing digital disease models that can capture the molecular biological complexity of disease in individual patients. We aim to harness these disease models to identify optimal treatments for each individual patient. Paper I: We started by exploring the usefulness of OMIC-based approaches for diagnostic and therapeutic predictions. Utilizing a single-cell RNA-sequenced mouse model of antigen-induced arthritis, we aimed to prioritize cell types and therapeutic targets. Initial pathway enrichment analyses did not yield relevant prioritization, prompting an investigation into network-based approaches. Multi-cellular disease models (MCDMs) for AIA and human rheumatoid arthritis were constructed, incorporating predicted cell type interactions. Centrality analysis indicated that these interactions could quantify a cell type’s relative importance in disease pathogenesis. We hypothesized that transcriptomic alterations in central cell types might reflect the MCDM, serving as potential diagnostic markers. An analysis of CD4+ T cells from patients with 13 different inflammatory diseases and healthy controls demonstrated that these profiles could discriminate between healthy and diseased states and among diseases. Furthermore, a network-based approach identified drugs targeting disease- associated changes common to multiple inflammatory diseases. Notably, one of these drugs, bezafibrate, successfully dampened inflammation in the AIA mouse model. Paper II: Building on the insights from Paper I, we investigated multicellular network models (MNMs) with time as an additional dimension. Using seasonal allergic rhinitis (SAR) as a disease model, we analyzed time-series scRNAseq data to construct MNMs of inflammatory diseases. We identified thousands of disease-associated expression changes across multiple cell types, varying at different disease stages. Notably, upstream regulators (URs) of these changes were also stage-dependent and multidirectional. To prioritize URs for drug discovery, we focused on those causing significant expression changes in multiple cell types across all time points. This strategy was validated through similar analyses of atopic dermatitis, ulcerative colitis, and Crohn’s disease, confirming that ranked URs aligned with the efficacy of existing drugs targeting the URs in the respective diseases. Furthermore, experimental validation included targeting the top-ranked regulatory gene in SAR, which was more effective than previously discovered IL4 inhibition. Paper III: While Paper I established the use of transcriptomic data for therapeutic predictions, it focused on overlapping disease-related changes across multiple inflammatory diseases and considered transcriptomic changes in only one cell type. Paper II indicated a potential benefit in UR prioritization in numerous cell types. However, it yielded heterogeneous results and was limited by the fact that few drugs directly target URs. Neither of these approaches was feasible for individualized drug predictions. Drawing on previous insights by us and others, we next aimed to develop digital disease models for individual patients, termed digital twins, with the capability for drug efficacy screening. We proposed scDrugPrio, a strategy utilizing single-cell scRNA-sequencing-based multicellular disease models incorporating key biological and pharmacological properties, such as varying gene expression levels, varying gene interactions within and between cell types, and drug effect. scDrugPrio was constructed based on a mouse model of arthritis and validated by improved precision/recall for known drugs and in vitro studies of predicted drugs that were FDA approved for other diseases and had not yet been tried in rheumatoid arthritis or mouse arthritis. For validation, scDrugPrio was applied to human multiple sclerosis as well as Crohn’s disease data that included tissue samples from healthy and sick tissue of all patients; scDrugPrio was able to identify relevant treatments for individual patients and could distinguish anti-TNF responders from non-responders. Conclusion: This thesis demonstrates a framework for constructing digital disease models for personalized therapeutic predictions that might hold potential for better clinical treatment decisions. By leveraging advanced genome-wide analyses and network-based approaches, we may enhance the precision and efficacy of treatments for immune-mediated inflammatory diseases, bringing personalized medicine closer to clinical reality.
Sa L K Bak M Hizmetlerinde Enfeksiyonlar N Kontrol Ve Nlenmesi
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Author : Hanefi Cem GÜL
language : tr
Publisher: Akademisyen Kitabevi
Release Date : 2022-06-16
Sa L K Bak M Hizmetlerinde Enfeksiyonlar N Kontrol Ve Nlenmesi written by Hanefi Cem GÜL and has been published by Akademisyen Kitabevi this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-16 with Medical categories.
Basic Immunology
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Author : Abul K. Abbas
language : en
Publisher:
Release Date : 2004
Basic Immunology written by Abul K. Abbas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Allergy categories.
The 2nd edition of this popular text emphasizes the fundamental concepts and principles of human immunology that students need to know, without overwhelming them with extraneous material. It leads the reader to a firm understanding of basic principles, using full-color illustrations; short, easy-to-read chapters; color tables that summarize key information clinical cases; and much more-all in a conveniently sized volume that's easy to carry. The New Edition has been thoroughly updated to reflect the many advances that are expanding our understanding of the field. The smart way to study! Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience. Your purchase of this book entitles you to access www.studentconsult.com at no extra charge. This innovative web site offers you... Access to the complete text and illustrations of this book. Integration links to bonus content in other STUDENT CONSULT titles. Content clipping for your handheld. An interactive community center with a wealth of additional resources. The more STUDENT CONSULT titles you buy, the more resources you can access online! Look for the STUDENT CONSULT logo on your favorite Elsevier textbooks! All of the scientific advances that are expanding the knowledge base in this rapidly evolving field.
Basic Immunology
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Author : Abul K. Abbas, MBBS
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-11-02
Basic Immunology written by Abul K. Abbas, MBBS and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-02 with Medical categories.
In this updated edition of Basic Immunology, the authors continue to deliver a clear, modern introduction to immunology, making this the obvious choice for today's busy students. Their experience as teachers, course directors, and lecturers helps them to distill the core information required to understand this complex field. Through the use of high-quality illustrations, relevant clinical cases, and concise, focused text, it's a perfectly accessible introduction to the workings of the human immune system, with an emphasis on clinical relevance. Concise, clinically focused content is logically organized by mechanism for efficient mastery of the material. Features an appendix of clinical cases and CD molecules. Includes numerous full-color illustrations, useful tables, and chapter outlines. Focus questions within each chapter are ideal for self-assessment and review. Key points bolded throughout the text make it easy to locate important information. Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology. Fully updated content equips you with the latest relevant advances in immunology. Revised and updated artwork enhances your visual learning of important principles and reduces the excessive factual details found in larger textbooks. Twelve brand-new animations available on Student Consult help further explain complex concepts. Student Consult eBook version included with purchase. This enhanced eBook experience gives you access to the text, figures, images, glossary of immunology terms, self-assessment questions, and references on a variety of devices.
Case Studies In Immunology
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Author : Raif S. Geha
language : en
Publisher: Garland Science
Release Date : 2008
Case Studies In Immunology written by Raif S. Geha and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
This volume recapitulates major topics of immunology as the background to a selection of real clinical cases that reinforce and extend the basic science, illustrating the importance of an understanding of immunology in diagnosis and therapy.
Sturkie S Avian Physiology
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Author : Colin G. Scanes
language : en
Publisher: Elsevier
Release Date : 2014-06-30
Sturkie S Avian Physiology written by Colin G. Scanes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-30 with Science categories.
Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Sixth Edition is thoroughly revised and updated, and features several new chapters with entirely new content on such topics as migration, genomics and epigenetics. Chapters throughout have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds. The Sixth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds. - Includes new chapters on endocrine disruptors, magnetoreception, genomics, proteomics, mitochondria, control of food intake, molting, stress, the avian endocrine system, bone, the metabolic demands of migration, behavior and control of body temperature - Features extensively revised chapters on the cardiovascular system, pancreatic hormones, respiration, pineal gland, pituitary gland, thyroid, adrenal gland, muscle, gastro-intestinal physiology, incubation, circadian rhythms, annual cycles, flight, the avian immune system, embryo physiology and control of calcium - Stands out as the only comprehensive, single volume devoted to bird physiology - Offers a full consideration of both blood and avian metabolism on the companion website (http://booksite.elsevier.com/ 9780124071605). Tables feature hematological and serum biochemical parameters together with circulating concentrations of glucose in more than 200 different species of wild birds
Encyclopedia Of The Eye
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Author : Joseph Besharse
language : en
Publisher: Academic Press
Release Date : 2010-05-27
Encyclopedia Of The Eye written by Joseph Besharse and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-27 with Science categories.
As the first comprehensive reference for the eye, its support structures, diseases, and treatments, Encyclopedia of the Eye is an important resource for all visual scientists, ophthalmologists, and optometrists, as well as researchers in immunology, infectious disease, cell biology, neurobiology and related disciplines. This four-volume reference is unique in its coverage of information on all tissues important for vision, including the retina, cornea and lens. It also covers the physiological and pathophysiologic processes that affect all eye tissues. This Encyclopedia is invaluable for graduate students and postdoctoral fellows who are seeking an introduction to an area of eye research. Each chapter explains the basic concepts and provides references to relevant chapters within the Encyclopedia and more detailed articles across the wider research literature. The Encyclopedia is also particularly useful for visual scientists and practitioners who are researching a new area, seeking deeper understanding of important research articles in fields adjacent to their own, or reviewing a grant outside their immediate area of expertise. Written by experts at a level that permits students to grasp key elements of a specific subject Provides an entryway into the major features of current eye research No other source puts this much information, so well-indexed and with so many helpful full color figures and graphics, in the hands of the ophthalmic scientist
Histology And Cell Biology An Introduction To Pathology E Book
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Author : Abraham L Kierszenbaum
language : en
Publisher: Elsevier Health Sciences
Release Date : 2011-04-12
Histology And Cell Biology An Introduction To Pathology E Book written by Abraham L Kierszenbaum and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-12 with Medical categories.
Histology and Cell Biology: An Introduction to Pathology uses a wealth of vivid, full-color images to help you master histology and cell biology. Dr. Abraham L. Kierszenbaum presents an integrated approach that correlates normal histology with cellular and molecular biology, pathology, and clinical medicine throughout the text. A unique pictorial approach—through illustrative diagrams, photomicrographs, and pathology photographs—paired with bolded words, key clinical terms in red, and clinical boxes and "Essential Concepts" boxes that summarize important facts give you everything you need to prepare for your course exams as well as the USMLE Step 1. Access to studentconsult.com, with USMLE-style multiple-choice review questions, downloadable images, and online only references. Easily find and cross-reference information through a detailed table of contents that highlights clinical examples in red. Review material quickly using pedagogical features, such as Essential Concept boxes, bolded words, and key clinical terms marked in red, that emphasize key details and reinforce your learning. Integrate cell biology and histology with pathology thanks to vivid descriptive illustrations that compare micrographs with diagrams and pathological images. Apply the latest developments in pathology through updated text and new illustrations that emphasize appropriate correlations. Expand your understanding of clinical applications with additional clinical case boxes that focus on applying cell and molecular biology to clinical conditions. Effectively review concepts and reinforce your learning using new Concept Map flow charts that provide a framework to illustrate the integration of cell-tissue-structure-function within a clinical-pathology context.
Hospital And Healthcare Security
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Author : Tony W York
language : en
Publisher: Butterworth-Heinemann
Release Date : 2009-10-12
Hospital And Healthcare Security written by Tony W York and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-12 with Business & Economics categories.
Hospital and Healthcare Security, Fifth Edition, examines the issues inherent to healthcare and hospital security, including licensing, regulatory requirements, litigation, and accreditation standards. Building on the solid foundation laid down in the first four editions, the book looks at the changes that have occurred in healthcare security since the last edition was published in 2001. It consists of 25 chapters and presents examples from Canada, the UK, and the United States. It first provides an overview of the healthcare environment, including categories of healthcare, types of hospitals, the nonhospital side of healthcare, and the different stakeholders. It then describes basic healthcare security risks/vulnerabilities and offers tips on security management planning. The book also discusses security department organization and staffing, management and supervision of the security force, training of security personnel, security force deployment and patrol activities, employee involvement and awareness of security issues, implementation of physical security safeguards, parking control and security, and emergency preparedness. Healthcare security practitioners and hospital administrators will find this book invaluable. - Practical support for healthcare security professionals, including operationally proven policies, and procedures - Specific assistance in preparing plans and materials tailored to healthcare security programs - Summary tables and sample forms bring together key data, facilitating ROI discussions with administrators and other departments - General principles clearly laid out so readers can apply the industry standards most appropriate to their own environment NEW TO THIS EDITION: - Quick-start section for hospital administrators who need an overview of security issues and best practices