Basic Pharmacokinetics Second Edition
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Basic Pharmacokinetics Second Edition
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Author : Mohsen A. Hedaya
language : en
Publisher: CRC Press
Release Date : 2012-02-09
Basic Pharmacokinetics Second Edition written by Mohsen A. Hedaya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-09 with Medical categories.
Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
Basic Pharmacokinetics And Pharmacodynamics
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Author : Sara E. Rosenbaum
language : en
Publisher: John Wiley & Sons
Release Date : 2016-12-27
Basic Pharmacokinetics And Pharmacodynamics written by Sara E. Rosenbaum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-27 with Medical categories.
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)
Basic Pharmacokinetics
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Author : Sunil S. Jambhekar
language : en
Publisher:
Release Date : 2023-04
Basic Pharmacokinetics written by Sunil S. Jambhekar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04 with categories.
Basic Pharmacokinetics
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Author : Mohsen A. Hedaya
language : en
Publisher: CRC Press
Release Date : 2007-04-23
Basic Pharmacokinetics written by Mohsen A. Hedaya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-23 with Medical categories.
This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.
Pharmacokinetics
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Author :
language : en
Publisher:
Release Date : 1982
Pharmacokinetics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with categories.
Handbook Of Basic Pharmacokinetics Including Clinical Applications
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Author : Wolfgang A. Ritschel
language : en
Publisher:
Release Date : 1986
Handbook Of Basic Pharmacokinetics Including Clinical Applications written by Wolfgang A. Ritschel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Basic Pharmacokinetics And Pharmacodynamics
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Author : Sara E. Rosenbaum
language : en
Publisher: John Wiley & Sons
Release Date : 2012-09-10
Basic Pharmacokinetics And Pharmacodynamics written by Sara E. Rosenbaum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-10 with Medical categories.
With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
Biopharmaceutics And Clinical Pharmacokinetics
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Author : Notari
language : en
Publisher: CRC Press
Release Date : 1986-08-26
Biopharmaceutics And Clinical Pharmacokinetics written by Notari and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-08-26 with Science categories.
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Nomenclature -- 1: Introduction -- References -- 2: Rates, Rate Constants, and Order -- I. Order -- II. Rates and Rate Constants -- 3: Active and Passive Transport -- I. Introduction -- II. Passive Transport -- III. Active Transport -- References -- 4: Pharmacokinetics -- I. Introduction -- II. Drug Disposition -- III. Constant-Rate Intravenous Infusion -- IV. Compartmental Models and Their Limitations -- V. Absorption Rate Constants -- References -- 5: Biopharmaccutics -- I. Extravascular Administration -- II. Absorption of Drugs from the Gastrointestinal Tract -- III. Factors Influencing Bioavailability -- IV. Evaluation of the Bioavailability of a Single Drug -- V. Drug Delivery to Prolong Duration -- References -- 6: Dosage Regimens -- I. Introduction -- II. Accumulation During Repetitive Dosing -- III. Adjustment of Dosage Regimen in Renal Failure -- IV. Multiple Dosing of Constant-Rate Intravenous Infusions -- References -- 7: Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy -- I. Introduction -- II. Antimicrobial Agents -- III. Pharmacokinetics of Prodrugs -- IV. Stereoisomers -- References -- 8: Pharmacokinetic Applications in Clinical Practice -- I. Introduction -- II. Pharmacokinetic Drug Interactions -- III. Clinical Pharmacokinetics -- References -- Appendix -- Index
Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition
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Author : Johan Gabrielsson
language : en
Publisher: CRC Press
Release Date : 2001-11-30
Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition written by Johan Gabrielsson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-30 with Medical categories.
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Handbook Of Basic Pharmacokinetics
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Author : Wolfgang A. Ritschel
language : en
Publisher:
Release Date : 1982-01-01
Handbook Of Basic Pharmacokinetics written by Wolfgang A. Ritschel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-01-01 with Pharmacokinetics categories.