Pharmacokinetics
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Clinical Pharmacokinetics
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Author : Soraya Dhillon
language : en
Publisher: Pharmaceutical Press
Release Date : 2006
Clinical Pharmacokinetics written by Soraya Dhillon and has been published by Pharmaceutical Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Chemotherapy categories.
Pharmacokinetics is the study of the process of drug absorption, distribution, metabolism and elimination. The aim of applying pharmacokinetic principles is to individualise the dose of drug, and optimise the outcome achieved in each patient. Its application reduces the chance of under-treatment, inadvertent poisoning, and dose related adverse effects. This new edition is specifically aimed at supporting undergraduate studies in pharmacokinetics, and has a strong emphasis on the application of pharmacokinetics in routine clinical practice. Clinical Pharmacokinetics also includes several case studies and 'questions and answers' to further aid understanding and revision.
Concepts In Clinical Pharmacokinetics
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Author : Joseph T. DiPiro
language : en
Publisher: ASHP
Release Date : 2010
Concepts In Clinical Pharmacokinetics written by Joseph T. DiPiro and has been published by ASHP this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Short Description: This popular teaching and self-instructional text makes it easier than ever to acquire a strong foundation in the basic principles of pharmacokinetics.
Introduction To Pharmacokinetics And Pharmacodynamics
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Author : Thomas N. Tozer
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2006
Introduction To Pharmacokinetics And Pharmacodynamics written by Thomas N. Tozer and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
Pharmacokinetics And Metabolism In Drug Design
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Author : Dennis A. Smith
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-21
Pharmacokinetics And Metabolism In Drug Design written by Dennis A. Smith and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-21 with Medical categories.
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
Basic Pharmacokinetics Second Edition
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Author : Mohsen A. Hedaya
language : en
Publisher: CRC Press
Release Date : 2012-02-09
Basic Pharmacokinetics Second Edition written by Mohsen A. Hedaya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-09 with Medical categories.
Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
Clinical Pharmacokinetics
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Author :
language : en
Publisher:
Release Date : 1996
Clinical Pharmacokinetics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Pharmacology categories.
Pharmacokinetics Of Drugs
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Author : Peter G. Welling
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pharmacokinetics Of Drugs written by Peter G. Welling and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.
Applied Pharmacokinetics Pharmacodynamics
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Author : Michael E. Burton
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2006
Applied Pharmacokinetics Pharmacodynamics written by Michael E. Burton and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.
Basic Pharmacokinetics And Pharmacodynamics
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Author : Sara E. Rosenbaum
language : en
Publisher: John Wiley & Sons
Release Date : 2016-12-27
Basic Pharmacokinetics And Pharmacodynamics written by Sara E. Rosenbaum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-27 with Medical categories.
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)
Basic Pharmacokinetics
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Author : Mohsen A. Hedaya
language : en
Publisher: CRC Press
Release Date : 2007-04-23
Basic Pharmacokinetics written by Mohsen A. Hedaya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-23 with Medical categories.
This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.