Bayesian Precision Medicine
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Bayesian Precision Medicine
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Author : Peter F. Thall
language : en
Publisher: CRC Press
Release Date : 2024-05-07
Bayesian Precision Medicine written by Peter F. Thall and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-07 with Mathematics categories.
Bayesian Precision Medicine presents modern Bayesian statistical models and methods for identifying treatments tailored to individual patients using their prognostic variables and predictive biomarkers. The process of evaluating and comparing treatments is explained and illustrated by practical examples, followed by a discussion of causal analysis and its relationship to statistical inference. A wide array of modern Bayesian clinical trial designs are presented, including applications to many oncology trials. The later chapters describe Bayesian nonparametric regression analyses of datasets arising from multistage chemotherapy for acute leukemia, allogeneic stem cell transplantation, and targeted agents for treating advanced breast cancer. Features: Describes the connection between causal analysis and statistical inference Reviews modern personalized Bayesian clinical trial designs for dose-finding, treatment screening, basket trials, enrichment, incorporating historical data, and confirmatory treatment comparison, illustrated by real-world applications Presents adaptive methods for clustering similar patient subgroups to improve efficiency Describes Bayesian nonparametric regression analyses of real-world datasets from oncology Provides pointers to software for implementation Bayesian Precision Medicine is primarily aimed at biostatisticians and medical researchers who desire to apply modern Bayesian methods to their own clinical trials and data analyses. It also might be used to teach a special topics course on precision medicine using a Bayesian approach to postgraduate biostatistics students. The main goal of the book is to show how Bayesian thinking can provide a practical scientific basis for tailoring treatments to individual patients.
Epigenetic Biomarker And Personalized Precision Medicine
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Author : Jiucun Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-21
Epigenetic Biomarker And Personalized Precision Medicine written by Jiucun Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-21 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Artificial Intelligence For Precision Medicine
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Author : Jun Deng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-16
Artificial Intelligence For Precision Medicine written by Jun Deng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-16 with Science categories.
Bayesian Methods In Pharmaceutical Research
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Author : Emmanuel Lesaffre
language : en
Publisher: CRC Press
Release Date : 2020-04-15
Bayesian Methods In Pharmaceutical Research written by Emmanuel Lesaffre and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Medical categories.
Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients. This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.
Exploring Medical Statistics Biostatistics Clinical Trials And Epidemiology
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Author : Arora, Geeta
language : en
Publisher: IGI Global
Release Date : 2024-07-18
Exploring Medical Statistics Biostatistics Clinical Trials And Epidemiology written by Arora, Geeta and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-18 with Medical categories.
In today's data-driven world, understanding and interpreting statistical information is more critical than ever, especially in medicine, where statistical methods are used to design and analyze clinical trials, study the distribution of disease in populations, and develop new treatments. In the era of evidence-based medicine, Exploring Medical Statistics: Biostatistics, Clinical Trials, and Epidemiology addresses the critical need for a grasp of statistical concepts. This book delves into biostatistics, clinical trials, and epidemiology, offering a robust foundation for understanding and interpreting statistical information in medicine. It explores biostatistics, elucidating fundamental elements such as probability, sampling, and hypothesis testing. The section on clinical trials covers the entire spectrum from trial design to ethical considerations, providing an invaluable resource for researchers navigating the complexities of medical research. Epidemiology, a cornerstone of public health, is examined in the book, offering insights into the distribution and determinants of diseases in populations. The application-focused section further extends the utility of medical statistics, encompassing public health, healthcare policy, and drug development.
Bayesian Methods In Pharmaceutical Research
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Author : Emmanuel Lesaffre
language : en
Publisher: CRC Press
Release Date : 2020-04-15
Bayesian Methods In Pharmaceutical Research written by Emmanuel Lesaffre and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Medical categories.
Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients. This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.
Digital Identity In The New Era Of Personalized Medicine
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Author : Ingrid Vasiliu-Feltes
language : en
Publisher:
Release Date : 2022
Digital Identity In The New Era Of Personalized Medicine written by Ingrid Vasiliu-Feltes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
"This book provides an overview of the current healthcare legal and regulatory landscape, as well as some of the major challenges and opportunities we face in this digital-, virtual- and precision medicine powered era, covering systems integration, interoperability, portability, standardization, as well as ethical considerations"--
Statistics In Precision Health
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Author : Yichuan Zhao
language : en
Publisher: Springer Nature
Release Date : 2024-07-09
Statistics In Precision Health written by Yichuan Zhao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-09 with Medical categories.
This book discusses statistical methods and their innovative applications in precision health. It serves as a valuable resource to foster the development of this growing field within the context of the big data era. The chapters cover a wide range of topics, including foundational principles, statistical theories, new procedures, advanced methods, and practical applications in precision medicine. Particular attention is devoted to the interplay between precision health, big data, and mobile health research, while also exploring precision medicine's role in clinical trials, electronic health record data analysis, survival analysis, and genomic studies. Targeted at data scientists, statisticians, graduate students, and researchers in academia, industry, and government, this book offers insights into the latest advances in personalized medicine using advanced statistical techniques.
Development Of Gene Therapies
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Author : Avery McIntosh
language : en
Publisher: CRC Press
Release Date : 2024-05-23
Development Of Gene Therapies written by Avery McIntosh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-23 with Mathematics categories.
Cell and gene therapies have become the third major drug modality in pharmaceutical medicine of the 21st century after low molecular weight and antibody drugs. The gene therapy (GTx) field is rapidly advancing, and yet there are still fundamental scientific questions that remain to be answered. Development of GTx products poses unique challenges and opportunities for drug developers. However, there is lack of a systematic exposition of the GTx product development and the pivotal role of the biostatistician in this process. Development of Gene Therapies: Strategic, Scientific, and Regulatory, and Access Considerations attempts to summarize the current state-of-the-art strategic, scientific, statistical, and regulatory aspects of GTx development. Intended to provide an exposition to the GTx new product development through peer-reviewed papers written by subject matter experts in this emerging field, this book will be useful for researchers in gene therapy drug development, biostatisticians, regulators, patient advocates, graduate students, and the finance and business development community . Key Features: A collection of papers covering a wide spectrum of topics in gene therapies (GTx), written by leading subject matter experts An exposition of the core principles of GTx product development, emerging business models, industry standards, best practices, and regulatory pathways An exposition of statistical and innovative modeling tools for design and analysis of clinical trials of GTx Insights into commercial models, access hurdles, and health economics of gene therapies Case studies of successful GTx approvals from core team members that developed the first two FDA-approved AAV gene therapies: Luxturna and Zolgensma A discussion of potential benefits and hurdles to be overcome for GTx in coming years from a multi-stakeholder perspective
Principles And Practice Of Clinical Trials
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Author : Steven Piantadosi
language : en
Publisher: Springer Nature
Release Date : 2022-07-19
Principles And Practice Of Clinical Trials written by Steven Piantadosi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-19 with Medical categories.
This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.