Best Synthetic Methods
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Best Synthetic Methods
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Author : Chris Timperley
language : en
Publisher: Newnes
Release Date : 2014-12-01
Best Synthetic Methods written by Chris Timperley and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-01 with Technology & Engineering categories.
Best Synthetic Methods: Organophosphorus (V) Chemistry provides systematic coverage of the most common classes of pentavalent organophosphorus compounds and reagents (including phosphonyl, phosphoryl, and organophosphates), and allows researchers an easy point of entry into this complex and economically important field. The book follows the Best Synthetic Methods format, containing practical methods, synthetic tips, and shortcuts. Where relevant, articles include toxicity data and historical context for the reactions. Typical analytical and spectroscopic data are also presented to enable scientists to identify key compound characteristics. The book is a valuable companion to research chemists in both academia and industry, summarizing the best practical methods (often originating in difficult-to-access, foreign-language primary literature) in one place. It is ideally suited for those working on industrial applications of these compounds, including insecticides, herbicides, flame retardants, and plasticizers. Includes a mixture of tried and tested, historical methods that are proven to work, alongside new methods to provide scientists with a quick, time-saving resource of reliable methods Includes tips and tricks to get reactions to work; important information often missing from other sources Includes key analytical data for compounds, so scientists have one handy resource to select, perform, and analyze the best reaction
Best Synthetic Methods Acetylenes Allenes And Cumulenes
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Author : Lambert Brandsma
language : en
Publisher: Elsevier
Release Date : 2003-12-16
Best Synthetic Methods Acetylenes Allenes And Cumulenes written by Lambert Brandsma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-16 with Science categories.
There is a vast and often bewildering array of synthetic methods and reagents available to organic chemists today. The Best Synthetic Methods series allows any scientist who is interested in the chemical transformations of molecules to choose between all the alternatives and assess their real advantages and limitations. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry. Best Synthetic Methods: Acetylenes, Allenes and Cumulenes is the product of the author's many years practical experience and reading of the original literature. It contains a valuable distillation and critical evaluation of the Best Synthetic Methods for the formation and reaction of molecules containing carbon-carbon triple bonds or cumulative carbon-carbon double bonds. A brief review of each area is provided, but the emphasis in all cases is on describing efficient practical methods to effect the transformations described. The reader can therefore use this book to rapidly review and select the best methods of performing a synthetic conversion to create or modify a molecule containing an acetylene, allene or cumulene functionality. In addition, the documentation of a large number of experimental recipes enables the user to synthesise an unsaturated molecule without the need to access to the original literature. Reviews and evaluates the various methods for the formation and reaction of acetylenes, cumulenes and allenes Provides detailed practical experimental for many important reactions General tips and analytical data are provided from the author's own extensive research in this area
Synthesis Of Acetylenes Allenes And Cumulenes
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Author : H. D. Verkruijsse
language : en
Publisher: Academic Press
Release Date : 2004-01
Synthesis Of Acetylenes Allenes And Cumulenes written by H. D. Verkruijsse and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01 with Science categories.
There is a vast and often bewildering array of synthetic methods and reagents available to organic chemists today. The Best Synthetic Methods series allows any scientist who is interested in the chemical transformations of molecules to choose between all the alternatives and assess their real advantages and limitations. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry. This book is the product of the author's many years practical experience and reading of the original literature. It contains a valuable distillation and critical evaluation of the Best Synthetic Methods for the formation and reaction of molecules containing carbon-carbon triple bonds or cumulative carbon-carbon double bonds. A brief review of each area is provided, but the emphasis in all cases is on describing efficient practical methods to effect the transformations described. The reader can therefore use this book to rapidly review and select the best methods of performing a synthetic conversion to create or modify a molecule containing an acetylene, allene or cumulene functionality. In addition, the documentation of a large number of experimental recipes enables the user to synthesise an unsaturated molecule without the need to access to the original literature. - Reviews and evaluates the various methods for the formation and reaction of acetylenes, cumulenes and allenes. - Provides detailed practical experimental for many important reactions. - General tips and analytical data are provided from the author's own extensive research in this area.
Synthetic Methods In Drug Discovery
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Author : David C. Blakemore
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016
Synthetic Methods In Drug Discovery written by David C. Blakemore and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Drug development categories.
The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
Organomagnesium Methods In Organic Chemistry
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Author : Basil J. Wakefield
language : en
Publisher: Academic Press
Release Date : 1995-03-16
Organomagnesium Methods In Organic Chemistry written by Basil J. Wakefield and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-16 with Science categories.
The book opens with a general overview of the constitution and reactivity of organomagnesium compounds, followed by information on handling them and on their detection and estimation. Throughout, practical aspects aswell as principles are emphasized. The chapters on the synthesis of organomagnesium compounds cover the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes, as well as the traditional preparation of Grignard reagents. Preparations by metallation and metal-halogen exchanges are also included, as are newer methods such as hydromagnesiation of alkenes and alkynes. Systematic coverage is provided on synthetically useful reactions of organomagnesium compounds. Of fundamental importance in organic synthesis are carbon-carbon bond forming reactions; additions to carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-sulfur multiple bonds; and nucleophilic substitution at carbon. The formation of carbon-heteroatom bonds in organic compounds is described, where the heteroatom is hydrogen, nitrogen, oxygen, sulfur, or halogen. Finally, the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds is outlined. Representative experimental procedures are included throughout the book, and tables with references to well-described examples are provided. Presents a general overview of the constitution and reactivity of organomagnesium compounds Provides coverage on the detection and estimation of organomagnesium compounds Emphasizes practical aspects as well as principles Covers the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes Includes preparations by metallation and metal-halogen exchanges Reviews new preparation methods such as hydromagnesiation of alkenes and alkynes Outlines information on synthetically useful reactions of organomagnesium compounds Describes the formation of carbon-heteroatom bonds in organic compounds Addresses the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds Includes representative procedures and tables with references to well-described examples
Indoles
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Author : Richard J. Sundberg
language : en
Publisher: Academic Press
Release Date : 1996-07-16
Indoles written by Richard J. Sundberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-16 with Science categories.
Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors Discusses methods for preparing indoles by annelation of pyrroles Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles Considers use of cycloaddition reactions for synthetic elaboration of indoles
Design And Optimization In Organic Synthesis
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Author : Rolf Carlson
language : en
Publisher: Elsevier
Release Date : 2005-04-08
Design And Optimization In Organic Synthesis written by Rolf Carlson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-08 with Science categories.
Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes. This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry, and is suitable for those with no experience in the field. * Contains recalculated models and redrawn figures, as well as new chapters on for example, the design of combinatorial libraries * Presents strategies to explore experimental conditions and methodologies * Enables the analysis and prediction of the best synthetic procedures
Thiophenes
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Author : Salo Gronowitz
language : en
Publisher: Elsevier
Release Date : 2004-05-12
Thiophenes written by Salo Gronowitz and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-12 with Science categories.
There is a vast and often bewildering array of synthetic methods and reagents available to organic chemists today. The Best Synthetic Methods series allows any scientist who is interested in the chemical transformations of molecules to choose between all the alternatives and assess their real advantages and limitations. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry. This book is the product of the authors many years practical experience and reading of the original literature. It contains a valuable distillation and critical evaluation of the Best Synthetic Methods for the formation and reaction of thiophenes (five membered heterocycles containing a ring sulfur) or polymers containing a thiophene functionality (thienyls). A brief review of each area is provided, but the emphasis in all cases is on describing efficient practical methods to effect the transformations described. The reader can therefore use this book to rapidly review and select the best methods of performing a synthetic conversion to create or modify a specifically substituted thiophene. Although this book contains many references to the original literature, the large number of experimental recipes enables the user to prepare a thiophene derivative without access to the original literature. These features make the handbook especially useful for physicists working in material sciences and organic/pharmaceutical chemists, who rapidly want to find out the availability of (or how to make) a specific thiophene. Contains a systematic description and critical evaluation of the best methods for preparation of thiophenes and polymers containing thiophenes Rapid location of methods achieved by systematic division of substituents following the periodic table All chapters are richly illustrated by detailed experimental proceedures for the synthesis of five membered heterocycles containing sulfur
Free Radical Chain Reactions In Organic Synthesis
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Author : William B. Motherwell
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Free Radical Chain Reactions In Organic Synthesis written by William B. Motherwell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Written for both the experienced practitioner and the newcomer, this book provides essential guidance to the practical aspects of free radical chain reactions. The book presents tried and tested synthetic schemes as well as a selection of recently developed methods describing rationally designed, highly efficient syntheses giving high yield interconversions of functional groups and carbon*b1carbon bond formation under mild, neutral conditions. Written by two experienced practitioners in the field, this volume explodes the myth that free radicals are highly reactive, non-selective intermediates. Contains an extensive introduction discussing principles, advantages, and disadvantages of radical chain reactions Demonstrates functional group interconversions by radical chain reactions Lists carbon*b1carbon bond formations Presents inter- and intramolecular radical chain reactions Includes many examples and experimental details selected by experienced practitioners in this field
Tellurium In Organic Synthesis
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Author : Nicola Petragnani
language : en
Publisher: Elsevier
Release Date : 2010-07-07
Tellurium In Organic Synthesis written by Nicola Petragnani and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-07 with Science categories.
The increasing number of publications that use tellurium clearly demonstrates the important role of tellurium compounds as unique and powerful tools in a broad range of organic chemical manipulations, often characterized by their selective behavior. Tellurium in Organic Synthesis provides an overview of the principal aspects of organic tellurium chemistry. Many chapters have been enriched and updated in this second edition. New chapters include overviews of toxicology and pharmacology and a review on the preparation and reactivity of several tellurium heterocycles. The first part of the book focuses on the preparation of selected inorganic tellurium compounds and on the main classes of organotellurium compounds. The second part, and main interest of the book, details the use of these inorganic and organic compounds as reagents to perform specific organic manipulations and synthesis. Reactions covered include reduction, formation and reaction of anionic species, deprotection, tellurium cyclizations, formation of alkenes, use of vinyllic tellurides, free radical chemistry, transmetallations, and removal of tellurium. Overview of inorganic and organic tellurium chemistry Synthetic applications of tellurium compounds All topics accompanied by detailed experimental procedures