Binding And Linkage
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Binding And Linkage
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Author : Jeffries Wyman
language : en
Publisher: University Science Books
Release Date : 1990
Binding And Linkage written by Jeffries Wyman and has been published by University Science Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Science categories.
Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.
Energetics Of Biological Macromolecules
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Author : Michael L. Johnson
language : en
Publisher: Elsevier
Release Date : 1998
Energetics Of Biological Macromolecules written by Michael L. Johnson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Allosteric regulation categories.
Essential publication for researchers in all fields of life sciences. Key Features * Major topics covered include: * Deciphering rules of helix stability in peptides * Protein Folding in Membranes * Molecular Crowding * Study of the Bohr Effect in Hemoglobin Intermediates * Photoacoustic Calorimetry of Proteins * Theoretical Aspects of Isothermal Titration Calorimetry * Energetic Methods to Study Bifunctional Biotin Repressor.
Introduction To Macromolecular Binding Equilibria
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Author : Charles P. Woodbury
language : en
Publisher: CRC Press
Release Date : 2007-11-08
Introduction To Macromolecular Binding Equilibria written by Charles P. Woodbury and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-08 with Science categories.
Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat
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Author :
language : en
Publisher: Delene Kvasnicka
Release Date :
written by and has been published by Delene Kvasnicka this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Protein Ligand Binding Thermodynamics
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Author : Justin M. Miller
language : en
Publisher: American Chemical Society
Release Date : 2023-06-01
Protein Ligand Binding Thermodynamics written by Justin M. Miller and has been published by American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-01 with Science categories.
Ligand binding by macromolecules represents a core event of broad relevance to a range of systems, including catalytic systems alongside noncatalytic systems such as nucleic acid binding by transcription factors or extracellular ligand binding by proteins involved in signaling pathways. The scope of this primer is constrained to introduce only foundational models without significant discussion of more advanced topics such as allosteric or linkage effects. Linkage occurs when the binding of a ligand is influenced by the binding of another molecule of the same ligand (homotropic linkage), the binding of a different ligand (heterotropic linkage), physical variables such as temperature or pressure (physical linkage), or changes in macromolecular assembly state (polysteric linkage). Taking this into account, the foundational themes presented in this primer can be used to describe any macromolecule–ligand interaction either by direct use of the models and techniques described here or by applying them to develop more advanced models to explain additional complexities such as those allosteric or linkage effects just mentioned. The target audience of this primer is the senior undergraduate or junior graduate student who lacks a foundation in ligand-binding thermodynamics. As such, we have focused primarily on foundational thermodynamic treatments and presented only general discussions of relevant experimental designs. Readers of this primer will learn how to build a working understanding of common factors that promote energetic favorability for ligand binding; develop a functional toolbox to understand ligand binding from the perspective of collecting, plotting, and interpreting ligand-binding data; enhance proficiency in deriving thermodynamic mechanisms for ligand binding; and become comfortable in interpreting binding data reported in the literature and independently expanding knowledge beyond the scope introduced in this primer.
Technical Manual
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Author : United States Department of the Army
language : en
Publisher:
Release Date : 1955
Technical Manual written by United States Department of the Army and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1955 with categories.
In Silico Drug Discovery And Design
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Author : Claudio N. Cavasotto
language : en
Publisher: CRC Press
Release Date : 2015-08-06
In Silico Drug Discovery And Design written by Claudio N. Cavasotto and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-06 with Medical categories.
In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita
Troubleshooting Organizational Level
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Author :
language : en
Publisher:
Release Date : 1981
Troubleshooting Organizational Level written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Military trucks categories.
Studyguide For Binding And Linkage
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Author : Cram101 Textbook Reviews
language : en
Publisher: Cram101
Release Date : 2014-05-28
Studyguide For Binding And Linkage written by Cram101 Textbook Reviews and has been published by Cram101 this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-28 with categories.
Never HIGHLIGHT a Book Again! Includes all testable terms, concepts, persons, places, and events. Cram101 Just the FACTS101 studyguides gives all of the outlines, highlights, and quizzes for your textbook with optional online comprehensive practice tests. Only Cram101 is Textbook Specific. Accompanies: 9781891389641. This item is printed on demand.
Guide To Protein Purification
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Author : Murray P. Deutscher
language : en
Publisher: Gulf Professional Publishing
Release Date : 1990
Guide To Protein Purification written by Murray P. Deutscher and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Proteins categories.
Guide to Protein Purification , designed to serve the needs of the student, experienced researcher and newcomer to the field, is a comprehensive manual that provides all the up-to-date procedures necessary for purifying, characterizing, and handling proteins and enzymes in one source. Key Features* Detailed procedures newly written for this volume* Extensive practical information* Rationale and strategies for protein and enzyme purification* Personal perspectives on enzyme purification by eminent researchersAmong the Topics Covered* General methods for handling proteins and enzymes * Extraction, subcellular fractionation, and solubilization procedures * Comprehensive purification techniques * Specialized purification procedures * Protein characterization * Immunological procedures * Computer analysis of protein structure.