Bioassay Techniques For Drug Development

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Bioassay Techniques For Drug Development

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Author : Atta-ur-Rahman
language : en
Publisher: CRC Press
Release Date : 2001-10-04

Bioassay Techniques For Drug Development written by Atta-ur-Rahman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-04 with Medical categories.

The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa

In Vitro Bioassay Techniques For Anticancer Drug Discovery And Development

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Author : Dhanya Sunil
language : en
Publisher: CRC Press
Release Date : 2017-05-18

In Vitro Bioassay Techniques For Anticancer Drug Discovery And Development written by Dhanya Sunil and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-18 with Medical categories.

This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules. The major emphasis of the book is to present those bioassays which can be readily set up and practiced in any laboratory with limited funds, facilities or technical know-how.

Pharmaceutical Bioassays

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Author : Shiqi Peng
language : en
Publisher: John Wiley & Sons
Release Date : 2009-11-09

Pharmaceutical Bioassays written by Shiqi Peng and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-09 with Medical categories.

The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer’s, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any ­pharmaceutical researcher Suggests guidelines and systems to enhance communication between ­pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications

In Vitro Bioassay Techniques For Anticancer Drug Discovery And Development

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Author : Dhanya Sunil
language : en
Publisher: CRC Press
Release Date : 2022-07-12

In Vitro Bioassay Techniques For Anticancer Drug Discovery And Development written by Dhanya Sunil and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-12 with categories.

This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way into animal or clinical trials. In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules. The major emphasis of the book is to present those bioassays which can be readily set up and practiced in any laboratory with limited funds, facilities, or technical know-how. Key Features, Provides a user-friendly, one-stop, comprehensive and coherent foundation for in vitro anticancer drug development, An essential guide to young investigators starting a program on natural resources in the anticancer area from biodiversity-rich countries, This handbook presents old and new protocols that are relevant for cancer drug screening, The reader is offered an insight into the intricate processes in drug discovery and the importance and role of in vitro bioassays for screening compounds and their specific applications in the assessment of therapies for cancer, Useful for any pharmaceutical researcher or medicinal chemist researching the principles behind clinically relevant methods, ideas, and techniques in this field Book jacket.

Bioassay Methods In Natural Product Research And Drug Development

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Author : Lars Bohlin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Bioassay Methods In Natural Product Research And Drug Development written by Lars Bohlin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Bioassays In Experimental And Preclinical Pharmacology

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Author : Karuppusamy Arunachalam
language : en
Publisher:
Release Date : 2021

Bioassays In Experimental And Preclinical Pharmacology written by Karuppusamy Arunachalam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Biological assay categories.

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Drug Development Supported By Informatics

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Author : Hiroko Satoh
language : en
Publisher: Springer Nature
Release Date : 2024-10-18

Drug Development Supported By Informatics written by Hiroko Satoh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-18 with Science categories.

This book describes the state-of-the-art of chemoinformatics, bioinformatics, materials informatics and measurement/metrology informatics to develop drugs with desired activity or physicochemical properties and to optimize the functionality, efficacy, safety and quality of the compounds for drugs. Recently, "AI drug discovery", drug discovery research utilizing artificial intelligence technology such as machine learning, has attracted much attention. This book provides an overview of the four applied informatics fields and their applications in drug development for a wide spectrum of readers from learners to professional scientists in academia and industry. It focuses on the basic research stage of drug development with contributions from experts at the forefront of these fields. The authors hope that this book will be of assistance to explore new opportunities for collaboration between pharmaceutical science and informatics.

Introduction To Statistical Analysis Of Laboratory Data

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Author : Alfred Bartolucci
language : en
Publisher: John Wiley & Sons
Release Date : 2015-11-02

Introduction To Statistical Analysis Of Laboratory Data written by Alfred Bartolucci and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-02 with Mathematics categories.

Introduction to Statistical Analysis of Laboratory Data presents a detailed discussion of important statistical concepts and methods of data presentation and analysis Provides detailed discussions on statistical applications including a comprehensive package of statistical tools that are specific to the laboratory experiment process Introduces terminology used in many applications such as the interpretation of assay design and validation as well as “fit for purpose” procedures including real world examples Includes a rigorous review of statistical quality control procedures in laboratory methodologies and influences on capabilities Presents methodologies used in the areas such as method comparison procedures, limit and bias detection, outlier analysis and detecting sources of variation Analysis of robustness and ruggedness including multivariate influences on response are introduced to account for controllable/uncontrollable laboratory conditions

Rare Diseases And Orphan Products

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-04-03

Rare Diseases And Orphan Products written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-03 with Medical categories.

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Quantum Chemistry

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Author : Tomofumi Tada
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-21

Quantum Chemistry written by Tomofumi Tada and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-21 with Science categories.

Molecules, small structures composed of atoms, are essential substances for lives. However, we didn't have the clear answer to the following questions until the 1920s: why molecules can exist in stable as rigid networks between atoms, and why molecules can change into different types of molecules. The most important event for solving the puzzles is the discovery of the quantum mechanics. Quantum mechanics is the theory for small particles such as electrons and nuclei, and was applied to hydrogen molecule by Heitler and London at 1927. The pioneering work led to the clear explanation of the chemical bonding between the hydrogen atoms. This is the beginning of the quantum chemistry. Since then, quantum chemistry has been an important theory for the understanding of molecular properties such as stability, reactivity, and applicability for devices. This book is devoted for the theoretical foundations and innovative applications in quantum chemistry.