Biocatalysis In The Pharmaceutical And Biotechnology Industries
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Biocatalysis In The Pharmaceutical And Biotechnology Industries
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Author : Ramesh N. Patel
language : en
Publisher: CRC Press
Release Date : 2006-09-26
Biocatalysis In The Pharmaceutical And Biotechnology Industries written by Ramesh N. Patel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-26 with Science categories.
Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.
Biocatalysis For The Pharmaceutical Industry
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Author : Junhua (Alex) Tao
language : en
Publisher: John Wiley & Sons
Release Date : 2009-07-23
Biocatalysis For The Pharmaceutical Industry written by Junhua (Alex) Tao and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-23 with Science categories.
Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.
Biocatalytic Membrane Reactors
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Author : Enrico Drioli
language : en
Publisher: CRC Press
Release Date : 2020-10-07
Biocatalytic Membrane Reactors written by Enrico Drioli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-07 with Medical categories.
This research level reference book has been co-written by Enrico Drioli, perhaps one of the world's best known researchers into membrane technology. The application of membrane technology to chemical transformation and molecular separation are beginning to be exploited in the pharmaceutical science and biotechnology industries, but there is a need for researchers and students to have up-to-date literature - and this book provides it. The book will be of interest to students of chemistry, chemical engineering, pharmacy and biotechnology.
Biocatalysis
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Author : Gonzalo de Gonzalo
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-11-02
Biocatalysis written by Gonzalo de Gonzalo and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-02 with Science categories.
Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.
Biocatalysis For Practitioners
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Author : Gonzalo de Gonzalo
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-13
Biocatalysis For Practitioners written by Gonzalo de Gonzalo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-13 with Science categories.
This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Applied Biocatalysis In Pharmaceuticals
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Author : Vivek Kothari
language : en
Publisher: Daya Books
Release Date : 2007
Applied Biocatalysis In Pharmaceuticals written by Vivek Kothari and has been published by Daya Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Bioacatalysis Has Increasingly Become The Technology Of Choice To Introduce Chirality In Fine-Chemical Processes. Biocatalysis Sculpts Chemical Precursors Into The Precise Molecular Shapes That Are The Heart Of Many Pharmaceuticals. In Reviewing How Biocatalysis Can Be Applied To Improve Chiral Synthesis For Pharmaceutical It Becomes Clear That There Will Be Many Opportunities Using A Simple Enzyme System But That Many Of The More Useful Applications Will Require The Whole Cell Because Of The Requirement For Cofactors. In The Ever More Global Commercial Arena, Biocatalysts Becomes Ever More Central To The Competitiveness Of Individual Products, Companies, Industries, And Countries. The Use Of Biocatalysis Often Leads To Less Complex, Syntheses, Lower Production Costs, And More Sustainable Production Processes. Written For Practitioners And Students Of Chemistry, Biology And Bioengineering, This Book Provides A Comprehensive Review Of The Applications Of Biocatalysis In The Pharmaceutical Industry. Contents Chaptre 1: Introduction; Chapter 2: Synthesis Of Chiral Intermediates; Chapter 3: Synthesis Of Amino Alcohols; Chapter 4: Enzymatic Synthesis Of Amplicillin; Chapter 5: Synthesis Of Chiral Amines With W-Transaminase; Chapter 6: Synthesis Of Chiral Long Chain Diamines And Tetramines; Chapter 7: Applications For Oxidoreductases; Chapter 8: Non-Aqueous Biocatalysis; Chapter 9: Eukaryotes For Industrial Biocatalysis; Chapter 10: Biopolymers For Biocatalysis; Chapter 11: Use Of Enantiopure Naphthalene Dihydrodiols; Chapter 12: Multidrug-Resistant Mycobacterium Tuberculosis; Chapter 13: Flavin Biochemistry.
Applied Biocatalysis
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Author : Lutz Hilterhaus
language : en
Publisher: John Wiley & Sons
Release Date : 2016-07-27
Applied Biocatalysis written by Lutz Hilterhaus and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Science categories.
This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Biocatalysis And Pharmaceuticals A Smart Tool For Sustainable Development
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Author : Andres R Alcantara
language : en
Publisher: MDPI
Release Date : 2019-10-30
Biocatalysis And Pharmaceuticals A Smart Tool For Sustainable Development written by Andres R Alcantara and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-30 with Science categories.
Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.
Applied Biocatalysis
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Author : John Whittall
language : en
Publisher: John Wiley & Sons
Release Date : 2020-08-21
Applied Biocatalysis written by John Whittall and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-21 with Science categories.
Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.
Green Biocatalysis
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Author : Ramesh N. Patel
language : en
Publisher: John Wiley & Sons
Release Date : 2016-05-12
Green Biocatalysis written by Ramesh N. Patel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-12 with Technology & Engineering categories.
Green Biocatalysis presents an exciting green technology that uses mild and safe processes with high regioselectivity and enantioselectivity. Bioprocesses are carried out under ambient temperature and atmospheric pressure in aqueous conditions that do not require any protection and deprotection steps to shorten the synthetic process, offering waste prevention and using renewable resources. Drawing on the knowledge of over 70 internationally renowned experts in the field of biotechnology, Green Biocatalysis discusses a variety of case studies with emphases on process R&D and scale-up of enzymatic processes to catalyze different types of reactions. Random and directed evolution under process conditions to generate novel highly stable and active enzymes is described at length. This book features: A comprehensive review of green bioprocesses and application of enzymes in preparation of key compounds for pharmaceutical, fine chemical, agrochemical, cosmetic, flavor, and fragrance industries using diverse enzymatic reactions Discussion of the development of efficient and stable novel biocatalysts under process conditions by random and directed evolution and their applications for the development of environmentally friendly, efficient, economical, and sustainable green processes to get desired products in high yields and enantiopurity The most recent technological advances in enzymatic and microbial transformations and cuttingedge topics such as directed evolution by gene shuffling and enzyme engineering to improve biocatalysts With over 3000 references and 800 figures, tables, equations, and drawings, Green Biocatalysis is an excellent resource for biochemists, organic chemists, medicinal chemists, chemical engineers, microbiologists, pharmaceutical chemists, and undergraduate and graduate students in the aforementioned disciplines.