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Biochemistry Of Nickel

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Biochemistry Of Nickel

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Author : Robert P. Hausinger
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Biochemistry Of Nickel written by Robert P. Hausinger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.

In this timely monograph, the author summarizes the rapidly growing body of knowledge regarding nickel by providing a balanced discussion of its harmful and beneficial effects. Coverage includes a history of nickel; the chemistry of nickel, descriptions of the four known enzymes which contain nickel; and nickel metabolism in microbes, plants, and animals. Taken as a whole, Dr. Hausinger's work will highlight key features of this important element and help define future research.

The Biological Chemistry Of Nickel

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Author : Deborah Zamble
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-04-04

The Biological Chemistry Of Nickel written by Deborah Zamble and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-04 with Science categories.

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Metal Ions In Biological Systems

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Author : Helmut Sigel
language : en
Publisher: CRC Press
Release Date : 1988-03-30

Metal Ions In Biological Systems written by Helmut Sigel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-03-30 with Science categories.

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Devoted solely to the vibrant research area of nickel and its role in biology, Volume 23 offers a comprehensive account of this important subject from the perspectives of 24 distinguished, international authorities. In 11 stimulating, in-depth chapters, Nickel and Its Role in Biology covers nickel and its function in the environment, in aquatic systems, in plants, as well as its metabolism in man and animals ... treats nickel ion binding to amino acids and peptides ... examines nickel in proteins and enzymes, including hydrogenases ... considers the interaction of nickel with nucleic acids and their constituents ... displays thoroughly the toxicology of nickel compounds ... and describes the analysis of nickel in biological materials. With more than 1,400 references to assist further research, Nickel and Its Role in Biology is an essential resource for scientists and students in several disciplines, including biochemistry; bioinorganic, inorganic, and coordination chemistry; biophysics; molecular biology; enzymology; pharmacology; clinical chemistry; nutrition; and toxicology. Book jacket.

The Bioinorganic Chemistry Of Nickel

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Author : Jack R. Lancaster
language : en
Publisher: Wiley-VCH
Release Date : 1988

The Bioinorganic Chemistry Of Nickel written by Jack R. Lancaster and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Bioinorganic chemistry categories.

Bioinorganic Chemistry Of Nickel

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Author : Michael J. Maroney
language : en
Publisher: MDPI
Release Date : 2020-06-16

Bioinorganic Chemistry Of Nickel written by Michael J. Maroney and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-16 with Science categories.

The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology.

Nickel And Its Surprising Impact In Nature

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Author : Astrid Sigel
language : en
Publisher: John Wiley & Sons
Release Date : 2007-03-13

Nickel And Its Surprising Impact In Nature written by Astrid Sigel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-13 with Science categories.

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons, launch a new Series “Metal Ions in Life Sciences”. The philosophy of the Series is based on the one successfully applied to a previous series published by another publisher, but the move from “biological systems” to “life sciences” will open the aims and scope and allow for the publication of books touching on the interface between chemistry, biology, pharmacology, biochemistry and medicine. Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2,800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine. In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenensis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights in the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases...and it reveals the chaperones of nickel metabolism.