Biofabrication And 3d Tissue Modeling
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Biofabrication And 3d Tissue Modeling
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Author : Dong-Woo Cho
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-01-02
Biofabrication And 3d Tissue Modeling written by Dong-Woo Cho and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-02 with Technology & Engineering categories.
3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.
3d Bioprinting
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Author : Dong-Woo Cho
language : en
Publisher: Springer Nature
Release Date : 2019-12-04
3d Bioprinting written by Dong-Woo Cho and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Medical categories.
This text advances fundamental knowledge in modeling in vitro tissues/organs as an alternative to 2D cell culture and animal testing. Prior to engineering in vitro tissues/organs,the descriptions of prerequisites (from pre-processing to post-processing) in modeling in vitro tissues/organs are discussed. The most prevalent technologies that have been widely used for establishing the in vitro tissue/organ models are also described, including transwell, cell spheroids/sheets, organoids, and microfluidic-based chips. In particular, the authors focus on 3D bioprinting in vitro tissue/organ models using tissue-specific bioinks. Several representative bioprinting methods and conventional bioinks are introduced. As a bioink source, decellularized extracellular matrix (dECM) are importantly covered, including decellularization methods, evaluation methods for demonstrating successful decellularization, and material safety. Taken together, the authors delineate various application examples of 3D bioprinted in vitro tissue/organ models especially using dECM bioinks.
Engineering 3d Tissue Test Systems
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Author : Karen J.L. Burg
language : en
Publisher: CRC Press
Release Date : 2017-07-28
Engineering 3d Tissue Test Systems written by Karen J.L. Burg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-28 with Medical categories.
Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.
Biofabrication
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Author : Joydip Kundu
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-03-18
Biofabrication written by Joydip Kundu and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-18 with Medical categories.
Biomaterials have advanced from merely interacting with the body to controlling biological processes toward the goal of tissue regeneration. In order to reconstitute a new tissue or repair a damaged/diseased tissue, three components are critical for regenerative medicine or tissue engineering: cells, biomaterials as scaffold substrates, and growth factors. Thus, the design and selection of materials and the methods used for scaffold fabrication play a very important role in tissue engineering and regenerative medicine. Recent developments in biofabrication strategies have created enormous possibilities for the construction of biomimetic 3D scaffolds, where well-defined architectures can be generated with suitable surface chemistry using appropriate materials. This chapter summarizes the materials used for the fabrication of scaffolds, the different types of scaffold manufacturing processes, and the basics of the various tissue-specific scaffolds used in regenerative medicine.
Essentials Of 3d Biofabrication And Translation
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Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2015-07-17
Essentials Of 3d Biofabrication And Translation written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-17 with Science categories.
Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms
3d Bioprinting
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Author : Ibrahim Tarik Ozbolat
language : en
Publisher: Academic Press
Release Date : 2016-11-21
3d Bioprinting written by Ibrahim Tarik Ozbolat and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Technology & Engineering categories.
3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics
Kenzan Method For Scaffold Free Biofabrication
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Author : Koichi Nakayama
language : en
Publisher: Springer Nature
Release Date : 2021-01-22
Kenzan Method For Scaffold Free Biofabrication written by Koichi Nakayama and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-22 with Technology & Engineering categories.
This is the first book about the “Kenzan” method for scaffold-free biofabrication, which does not rely on biomaterials as scaffolds to ensure correct multicellular spheroid positioning for building three dimensional construct only made from cells. The book explains the basic principles and concepts of the microneedle-based (“Kenzan”) method of building surgically-implantable tissue constructs using robotic cell spheroid-based three-dimensional bioprinting, a novel technology that opens up unique opportunities for the bioengineering of tissues and organs. First book on the novel Kenzan method of tissue engineering; Explains basic concepts and applications for organ regeneration modeling; Introduces a unique robotic system for scaffold-free cell construction.
3d Printing And Biofabrication
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Author : Aleksandr Ovsianikov
language : en
Publisher: Springer
Release Date : 2018-06-08
3d Printing And Biofabrication written by Aleksandr Ovsianikov and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-08 with Science categories.
This volume provides an in-depth introduction to 3D printing and biofabrication and covers the recent advances in additive manufacturing for tissue engineering. The book is divided into two parts, the first part on 3D printing discusses conventional approaches in additive manufacturing aimed at fabrication of structures, which are seeded with cells in a subsequent step. The second part on biofabrication presents processes which integrate living cells into the fabrication process.
Biofabrication And 3d Tissue Modeling
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Author : Dong-Woo Cho
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-01-02
Biofabrication And 3d Tissue Modeling written by Dong-Woo Cho and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-02 with Technology & Engineering categories.
3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.
3d Bioprinting
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Author : Jeremy M. Crook
language : en
Publisher: Springer Nature
Release Date : 2020-03-23
3d Bioprinting written by Jeremy M. Crook and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-23 with Science categories.
This volume explores the latest developments and contributions to the field of 3D bioprinting, and discusses its use for quality R&D and translation. The chapters in this book are divided into two parts: Part one covers generic themes in bioprinting to introduce novice readers to the field, while also providing experts with new and helpful information. Part two discusses protocols used to prepare, characterize, and print a variety of biomaterials, cells, and tissues. These chapters also emphasize methods used for printing defined and humanized constructs suitable for human tissue modelling in research and applicable to clinical product development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, 3D Bioprinting: Methods and Protocols is a valuable resource for researchers and bioprinting laboratories/facilities interested in learning more about this rapidly evolving technology.