Bioinformatics And Biomarker Discovery

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Bioinformatics And Biomarker Discovery

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Author : Francisco Azuaje
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-24

Bioinformatics And Biomarker Discovery written by Francisco Azuaje and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-24 with Science categories.

This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations

Cancer Biomarkers

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Author : Mahmoud H. Hamdan
language : en
Publisher: John Wiley & Sons
Release Date : 2007-04-23

Cancer Biomarkers written by Mahmoud H. Hamdan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-23 with Science categories.

Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: * Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies * Includes a detailed discussion of protein networks and protein phosphorylation in cancer * Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics * Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies * Discusses related regulatory and ethical issues With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.

Omics Technologies In Cancer Biomarker Discovery

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Author : Xuewu Zhang
language : en
Publisher: CRC Press
Release Date : 2011-03-10

Omics Technologies In Cancer Biomarker Discovery written by Xuewu Zhang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-10 with Science categories.

The early detection of human cancer is still one of the great challenges in the battle against this disease. Single biomarkers are not likely to provide sufficient diagnostic power and multibiomarker assays should be developed in order to reach high diagnostic accuracy for cancer screening at the population level. Omics technologies are emerging ne

Comprehensive Biomarker Discovery And Validation For Clinical Application

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Author : Péter Horvatovich
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013

Comprehensive Biomarker Discovery And Validation For Clinical Application written by Péter Horvatovich and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.

This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (EMEA and FDA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of different LC-MS profiling platforms and affinity array for screening complex body fluids. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers.

Multivariate Biomarker Discovery

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Author : Darius M. Dziuda
language : en
Publisher: Cambridge University Press
Release Date : 2024-05-31

Multivariate Biomarker Discovery written by Darius M. Dziuda and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-31 with Medical categories.

A concise guide to all aspects of predictive modeling for biomarker discovery for medical diagnosis, prognosis, and personalized medicine.

Biomarker Discovery And Clinical Outcome Prediction Using Knowledge Based Bioinformatics

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Author : John H. Phan
language : en
Publisher:
Release Date : 2009

Biomarker Discovery And Clinical Outcome Prediction Using Knowledge Based Bioinformatics written by John H. Phan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

Paradigm Shift Multidisciplinary Research For A Changing World Volume 2

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Author : Dr. Sagarika Dash
language : en
Publisher: REDSHINE Publication
Release Date : 2024-08-31

Paradigm Shift Multidisciplinary Research For A Changing World Volume 2 written by Dr. Sagarika Dash and has been published by REDSHINE Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-31 with Antiques & Collectibles categories.

Systems Biomedicine Approaches In Cancer Research

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Author : Shailza Singh
language : en
Publisher: Springer Nature
Release Date : 2022-08-10

Systems Biomedicine Approaches In Cancer Research written by Shailza Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-10 with Science categories.

This book presents the applications of systems biology and synthetic biology in cancer medicine. It highlights the use of computational and mathematical models to decipher the complexity of cancer heterogeneity. The book emphasizes the modeling approaches for predicting behavior of cancer cells, tissues in context of drug response, and angiogenesis. It introduces cell-based therapies for the treatment of various cancers and reviews the role of neural networks for drug response prediction. Further, it examines the system biology approaches for the identification of medicinal plants in cancer drug discovery. It explores the opportunities for metabolic engineering in the realm of cancer research towards development of new cancer therapies based on metabolically derived targets. Lastly, it discusses the applications of data mining techniques in cancer research. This book is an excellent guide for oncologists and researchers who are involved in the latest cancer research.

Pacific Symposium On Biocomputing 2014

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Author : Russ B Altman
language : en
Publisher: World Scientific
Release Date : 2013-11-19

Pacific Symposium On Biocomputing 2014 written by Russ B Altman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-19 with Science categories.

The Pacific Symposium on Biocomputing (PSB) 2014 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2014 will be held from January 3 - 7, 2014 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2014 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis

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Author : Arup Giri
language : en
Publisher: Academic Press
Release Date : 2025-05-30

Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis written by Arup Giri and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Science categories.

Exploring Noninvasive Disease Biomarkers with Urinary Omics Analysis offers a transformative journey into the world of non-invasive diagnostics. This comprehensive volume delves into the molecular foundations of urinary biomarkers, illuminating the intricate signatures that indicate various pathological conditions and elucidating the mechanisms behind their release into urine. Readers will gain invaluable insights into cutting-edge analytical technologies, methodologies, and data integration techniques essential for biomarker discovery. From genomic approaches to transcriptomics, proteomics, and metabolomics, each chapter provides a thorough examination of the latest advancements, accompanied by practical guidance and case studies showcasing their clinical applications across diverse health conditions.In addition to the foundational knowledge, the book highlights the clinical applications of urinary omics in diagnosing renal disorders, metabolic syndromes, and infectious diseases. It equips professionals and students with the tools needed to navigate the complexities of urinary omics, revolutionize personalized medicine, and advance transformative healthcare solutions. The practical guidance and case studies included in the book make it an invaluable resource for those looking to implement these advanced diagnostic techniques in clinical settings. - Provides a comprehensive exploration of urinary omics, including an in-depth analysis of genomics, proteomics, and metabolomics - Highlights advances in analytical technologies for analyzing urinary biomarkers, offering a comprehensive overview - Elucidates clinical application across health conditions, highlighting a holistic examination of urine's potential as a diagnostic reservoir