Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution
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Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution
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Author : Marco Fondi
language : en
Publisher: Firenze University Press
Release Date : 2011
Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution written by Marco Fondi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Bioinformatics, that is the interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences, is expected to gain a central role in next feature. Indeed, it has now affected several fields of biology, providing crucial hints for the understanding of biological systems and also allowing a more accurate design of wet lab experiments. In this work, the analysis of sequence data has be used in different fields, such as evolution (e.g. the assembly and evolution of metabolism), infections control (e.g. the horizontal flow of antibiotic resistance), ecology (bacterial bioremediation).
Tectono Metamorphic Evolution Of The Continental Units Along The Edge Between Alpine And Hercynian Corsica
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Author : Maria Di Rosa
language : en
Publisher: Firenze University Press
Release Date : 2022
Tectono Metamorphic Evolution Of The Continental Units Along The Edge Between Alpine And Hercynian Corsica written by Maria Di Rosa and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.
Functional Validation Of Genetic Variants Identified By Next Generation Sequencing In Malformations Of Cortical Development
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Author : Dalila De Vita
language : en
Publisher: Firenze University Press
Release Date : 2022
Functional Validation Of Genetic Variants Identified By Next Generation Sequencing In Malformations Of Cortical Development written by Dalila De Vita and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Medical categories.
Malformations of cortical development (MCDs) result from a disruption in the process of the human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated the identification of MCDs causing genes: in some cases, functional studies are needed to clarify the role of genetic variants. The aim of this PhD project has been to apply a multidisciplinary approach to identify causative mutations in patients with MCDs, validate the pathogenic role of the identified mutations, and assess the effectiveness of novel in vitro treatment for mTOR pathway related MCDs.
Isotopic Fractionation Study Towards Massive Star Forming Regions Across The Galaxy
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Author : Laura Colzi
language : en
Publisher: Firenze University Press
Release Date : 2022
Isotopic Fractionation Study Towards Massive Star Forming Regions Across The Galaxy written by Laura Colzi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.
Cerebral Small Vessel Disease And Cerebral Amyloid Angiopathy
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Author : Raffaella Valenti
language : en
Publisher: Firenze University Press
Release Date : 2018
Cerebral Small Vessel Disease And Cerebral Amyloid Angiopathy written by Raffaella Valenti and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects. We investigated clinical (neuroimaging and cognitive) biomarkers in the SVD, through a series of analyses from our five studies. Sporadic cerebral SVD is a complex 'micro-world' to be globally considered. All the relevant lesion types and SVD neuroimaging burden should be taken into account. The cumulative effects of microangiopathy burden in the brain of patients affected by SVD are crucial. Cognitive rehabilitation could represent a promising approach to prevent vascular dementia or to improve cognitive performances in patients with cerebral SVD. Longitudinal studies may provide more robust information about the progression and prognostic significance of our findings.
Molecular Imaging In Parkinson S Disease
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Author : Cristina Polito
language : en
Publisher: Firenze University Press
Release Date : 2011
Molecular Imaging In Parkinson S Disease written by Cristina Polito and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.
An Integrated Nonlinear Wind Waves Model For Offshore Wind Turbines
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Author : Enzo Marino
language : en
Publisher: Firenze University Press
Release Date : 2010
An Integrated Nonlinear Wind Waves Model For Offshore Wind Turbines written by Enzo Marino and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Coastal engineering categories.
This thesis presents a numerical model capable of simulating offshore wind turbines exposed to extreme loading conditions. External condition-based extreme responses are reproduced by coupling a fully nonlinear wave kinematic solver with a hydro-aero-elastic simulator. First, a two-dimensional fully nonlinear wave simulator is developed. The transient nonlinear free surface problem is formulated assuming the potential theory and a high-order boundary element method is implemented to discretize Laplace's equation. For temporal evolution a second-order Taylor series expansion is used. The code, after validation with experimental data, is successfully adopted to simulate overturning plunging breakers which give rise to dangerous impact loads when they break against wind turbine substructures. Emphasis is then placed on the random nature of the waves. Indeed, through a domain decomposition technique a global simulation framework embedding the numerical wave simulator into a more general stochastic environment is developed. The proposed model is meant as a contribution to meet the more and more pressing demand for research in the offshore wind energy sector as it permits taking into account dangerous effects on the structural response so as to increase the global structural safety level.
Bioinformatics Of Genome Evolution
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Author : Marco Fondi
language : en
Publisher:
Release Date : 2009
Bioinformatics Of Genome Evolution written by Marco Fondi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Legalit E Mutamenti Giurisprudenziali Nel Diritto Penale
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Author : Andrea Galante
language : it
Publisher: Firenze University Press
Release Date : 2021
Legalit E Mutamenti Giurisprudenziali Nel Diritto Penale written by Andrea Galante and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Law categories.
Se il legislatore volesse incriminare nuove condotte o aggravare il trattamento sanzionatorio previsto per tipologie di condotte già penalmente rilevanti, lo potrebbe fare solo con efficacia per il futuro in virtù del divieto costituzionale di retroattività. Qualora un comportamento penalmente irrilevante al momento della sua commissione diventi, al contrario, penalmente rilevante a seguito del verificarsi di un cambio di interpretazione giurisprudenziale oppure finisca per essere sanzionato in astratto con pene più sfavorevoli, quali garanzie sono riconosciute al cittadino? Il lavoro affronta, in prospettiva anche europea e comparata, il tema delle garanzie costituzionali riconosciute al singolo a fronte del verificarsi di un mutamento giurisprudenziale produttivo di conseguenze sfavorevoli.
Tuo Lumine
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Author : Maria Fedi
language : it
Publisher: Firenze University Press
Release Date : 2011
Tuo Lumine written by Maria Fedi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with History categories.
Starting from a vast documentary corpus, the result of in-depth archival research, the volume offers an original perspective on the main forms of entertainment in Pistoia between the seventeenth and eighteenth centuries, focusing in particular on the theatrical activity of the most important cultural institution in the city, the Accademia dei Risvegliati. The survey also examines realities of secondary importance that contributed to enriching the urban cultural fabric, such as the minor stages, the sacred theatre and private entertainment. A broader overview also allows the readers to frame the scope of festive celebrations and occasions for public entertainment, presented through significant exempla.