Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution
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Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution
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Author : Marco Fondi
language : en
Publisher: Firenze University Press
Release Date : 2011
Bioinformatics Of Genome Evolution From Ancestral To Modern Metabolism Phylogenomics And Comparative Genomics To Understand Microbial Evolution written by Marco Fondi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Bioinformatics, that is the interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences, is expected to gain a central role in next feature. Indeed, it has now affected several fields of biology, providing crucial hints for the understanding of biological systems and also allowing a more accurate design of wet lab experiments. In this work, the analysis of sequence data has be used in different fields, such as evolution (e.g. the assembly and evolution of metabolism), infections control (e.g. the horizontal flow of antibiotic resistance), ecology (bacterial bioremediation).
Bioinformatics Of Genome Evolution
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Author : Marco Fondi
language : en
Publisher:
Release Date : 2009
Bioinformatics Of Genome Evolution written by Marco Fondi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Tectono Metamorphic Evolution Of The Continental Units Along The Edge Between Alpine And Hercynian Corsica
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Author : Maria Di Rosa
language : en
Publisher: Firenze University Press
Release Date : 2022
Tectono Metamorphic Evolution Of The Continental Units Along The Edge Between Alpine And Hercynian Corsica written by Maria Di Rosa and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.
Models And Algorithms For Genome Evolution
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Author : Cedric Chauve
language : en
Publisher: Springer
Release Date : 2016-09-27
Models And Algorithms For Genome Evolution written by Cedric Chauve and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-27 with Computers categories.
This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.
Functional Validation Of Genetic Variants Identified By Next Generation Sequencing In Malformations Of Cortical Development
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Author : Dalila De Vita
language : en
Publisher: Firenze University Press
Release Date : 2022
Functional Validation Of Genetic Variants Identified By Next Generation Sequencing In Malformations Of Cortical Development written by Dalila De Vita and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Medical categories.
Malformations of cortical development (MCDs) result from a disruption in the process of the human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated the identification of MCDs causing genes: in some cases, functional studies are needed to clarify the role of genetic variants. The aim of this PhD project has been to apply a multidisciplinary approach to identify causative mutations in patients with MCDs, validate the pathogenic role of the identified mutations, and assess the effectiveness of novel in vitro treatment for mTOR pathway related MCDs.
Isotopic Fractionation Study Towards Massive Star Forming Regions Across The Galaxy
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Author : Laura Colzi
language : en
Publisher: Firenze University Press
Release Date : 2022
Isotopic Fractionation Study Towards Massive Star Forming Regions Across The Galaxy written by Laura Colzi and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.
An Integrated Nonlinear Wind Waves Model For Offshore Wind Turbines
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Author : Enzo Marino
language : en
Publisher: Firenze University Press
Release Date : 2010
An Integrated Nonlinear Wind Waves Model For Offshore Wind Turbines written by Enzo Marino and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Coastal engineering categories.
This thesis presents a numerical model capable of simulating offshore wind turbines exposed to extreme loading conditions. External condition-based extreme responses are reproduced by coupling a fully nonlinear wave kinematic solver with a hydro-aero-elastic simulator. First, a two-dimensional fully nonlinear wave simulator is developed. The transient nonlinear free surface problem is formulated assuming the potential theory and a high-order boundary element method is implemented to discretize Laplace's equation. For temporal evolution a second-order Taylor series expansion is used. The code, after validation with experimental data, is successfully adopted to simulate overturning plunging breakers which give rise to dangerous impact loads when they break against wind turbine substructures. Emphasis is then placed on the random nature of the waves. Indeed, through a domain decomposition technique a global simulation framework embedding the numerical wave simulator into a more general stochastic environment is developed. The proposed model is meant as a contribution to meet the more and more pressing demand for research in the offshore wind energy sector as it permits taking into account dangerous effects on the structural response so as to increase the global structural safety level.
Molecular Imaging In Parkinson S Disease
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Author : Cristina Polito
language : en
Publisher: Firenze University Press
Release Date : 2011
Molecular Imaging In Parkinson S Disease written by Cristina Polito and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.
Comparative Genomics
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Author : Francesca D. Ciccarelli
language : en
Publisher: Springer
Release Date : 2009-09-30
Comparative Genomics written by Francesca D. Ciccarelli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-30 with Science categories.
As genome-sequencing costs continue their downward spiral, sequencing of closely related organisms has become increasingly a?ordable. The growing amount of genomic data available demands for the constant development of computational tools to be applied in comparative genomics. The RECOMB Workshop on C- parative Genomics (RECOMB-CG) is devoted to bringing together scientists working on all aspects of comparative genomics, from computer scientists, ma- ematicians and statisticians working on novel computational approaches for genome analysis and comparison, to biologists applying these computational tools to study the structure and the evolution of prokaryotic and eukaryotic genomes. This volume contains the 19 papers presented at the 7th Annual RECOMB-CG workshop held during September 27–29, 2009 at the Renyi Institute, in Budapest, Hungary. The papers published in these proceedings were selected for oral p- sentation from 31 submissions from scientists around the world. Each paper was reviewed by at least three members of the Program Committee in a stringent and thoughtful peer-review process.
Computational Methods For Understanding Bacterial And Archaeal Genomes
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Author : Ying Xu
language : en
Publisher: Imperial College Press
Release Date : 2008
Computational Methods For Understanding Bacterial And Archaeal Genomes written by Ying Xu and has been published by Imperial College Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.