Bioinformatics Tools For Detection And Clinical Interpretation Of Genomic Variations
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Bioinformatics Tools For Detection And Clinical Interpretation Of Genomic Variations
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Author : Ali Samadikuchaksaraei
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-09-04
Bioinformatics Tools For Detection And Clinical Interpretation Of Genomic Variations written by Ali Samadikuchaksaraei and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-04 with Medical categories.
Genomic variations and phenotypic diversity are closely linked and form the underlying mechanism for development of many human diseases. This book addresses the methods of detection, analysis, and interpretation of genomic variations in clinically relevant scenarios. If your research or clinical practice involves handling of genomic sequencing data, this book is for you. Topics covered include: methods for identifying genetic diversity, the workflow for analyzing whole exome and whole genome sequencing data, local ancestry deconvolution models, the value of molecular patterns and pattern biomarkers in cancer diagnosis and prognosis, and genotyping and profiling resistance-associated variants of hepatitis C. If your research or clinical practice involves handling of genomic sequencing data, this book is for you.
Handbook Of Statistical Genomics
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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-09
Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-09 with Science categories.
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Omics Approaches In Veterinary Parasitology
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Author : Muhammad Sohail Sajid
language : en
Publisher: CRC Press
Release Date : 2024-11-28
Omics Approaches In Veterinary Parasitology written by Muhammad Sohail Sajid and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-28 with Medical categories.
Omics Approaches in Veterinary Parasitology: Diagnosis, Biomarkers, and Drug Development explores applications of omics approaches for diagnosis, biomarker discovery, and drug development against parasites of veterinary importance. It presents the fundamental principles of parasite biology and their complex physiological processes. The chapters review key aspects such as parasite life cycles, host-parasite interactions, and the molecular mechanisms that underlie parasitic diseases. The subsequent chapters delve into the principles and applications of genomics, transcriptomics, proteomics, and metabolomics in understanding parasites at a molecular level. The use of next-generation sequencing, PCR-based assays, and metagenomics in identifying and characterizing parasites for accurate and efficient diagnosis are also covered in detail. Toward the end, the book focuses on target identification, drug repurposing, and the optimization of drug efficacy while minimizing drug resistance using omics data. The book is useful for researchers, students, and professionals in the field of veterinary parasitology.
Practical Guide To Life Science Databases
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Author : Imad Abugessaisa
language : en
Publisher: Springer Nature
Release Date : 2022-01-06
Practical Guide To Life Science Databases written by Imad Abugessaisa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Science categories.
This book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Artificial Intelligence
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-07-31
Artificial Intelligence written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-31 with Medical categories.
Artificial intelligence (AI) is taking on an increasingly important role in our society today. In the early days, machines fulfilled only manual activities. Nowadays, these machines extend their capabilities to cognitive tasks as well. And now AI is poised to make a huge contribution to medical and biological applications. From medical equipment to diagnosing and predicting disease to image and video processing, among others, AI has proven to be an area with great potential. The ability of AI to make informed decisions, learn and perceive the environment, and predict certain behavior, among its many other skills, makes this application of paramount importance in today's world. This book discusses and examines AI applications in medicine and biology as well as challenges and opportunities in this fascinating area.
Genome Data Analysis
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Author : Ju Han Kim
language : en
Publisher: Springer
Release Date : 2019-04-30
Genome Data Analysis written by Ju Han Kim and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-30 with Computers categories.
This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.
Kernel Methods For Pattern Analysis
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Author : John Shawe-Taylor
language : en
Publisher: Cambridge University Press
Release Date : 2004-06-28
Kernel Methods For Pattern Analysis written by John Shawe-Taylor and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-28 with Computers categories.
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Biological Sequence Analysis
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Author : Richard Durbin
language : en
Publisher: Cambridge University Press
Release Date : 1998-04-23
Biological Sequence Analysis written by Richard Durbin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-04-23 with Medical categories.
Presents up-to-date computer methods for analysing DNA, RNA and protein sequences.
Computational Exome And Genome Analysis
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Author : Peter N. Robinson
language : en
Publisher: CRC Press
Release Date : 2017-09-13
Computational Exome And Genome Analysis written by Peter N. Robinson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-13 with Computers categories.
Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.
Predictive Preventive And Personalised Medicine From Bench To Bedside
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Author : Halina Podbielska
language : en
Publisher: Springer Nature
Release Date : 2023-10-30
Predictive Preventive And Personalised Medicine From Bench To Bedside written by Halina Podbielska and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-30 with Medical categories.
This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.