Biologic And Gene Therapy Of Autoimmune Disease
DOWNLOAD
Download Biologic And Gene Therapy Of Autoimmune Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Biologic And Gene Therapy Of Autoimmune Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Biologic And Gene Therapy Of Autoimmune Disease
DOWNLOAD
Author : C. Garrison Fathman
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2000-01-01
Biologic And Gene Therapy Of Autoimmune Disease written by C. Garrison Fathman and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-01 with Medical categories.
The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.
Biologics And Biosimilars
DOWNLOAD
Author : Xiaodong Feng
language : en
Publisher: CRC Press
Release Date : 2022-06-13
Biologics And Biosimilars written by Xiaodong Feng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-13 with Medical categories.
Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.
Gene Therapy For Autoimmune And Inflammatory Diseases
DOWNLOAD
Author : Yuti Chernajovsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-28
Gene Therapy For Autoimmune And Inflammatory Diseases written by Yuti Chernajovsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-28 with Medical categories.
In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
Gene Therapy Of Autoimmune Disease
DOWNLOAD
Author : Gerald J. Prud'homme
language : en
Publisher: Springer
Release Date : 2011-02-11
Gene Therapy Of Autoimmune Disease written by Gerald J. Prud'homme and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-11 with Medical categories.
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Autoimmune Diseases
DOWNLOAD
Author : James Chan
language : en
Publisher: IntechOpen
Release Date : 2012-07-25
Autoimmune Diseases written by James Chan and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-25 with Medical categories.
Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases.
Biologic Therapy In Patients With Juvenile Idiopathic Arthritis A Unique Single Centre Experience At The Scientific Research Pediatric Centre In The Russian Federation
DOWNLOAD
Author : A.A. Baranov
language : en
Publisher:
Release Date : 2012
Biologic Therapy In Patients With Juvenile Idiopathic Arthritis A Unique Single Centre Experience At The Scientific Research Pediatric Centre In The Russian Federation written by A.A. Baranov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Biotherapy
DOWNLOAD
Author : Paula Trahan Rieger
language : en
Publisher: Jones & Bartlett Publishers
Release Date : 1995
Biotherapy written by Paula Trahan Rieger and has been published by Jones & Bartlett Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
Rieger (U. of Texas M.D. Anderson Cancer Center) synthesizes knowledge about this rapidly expanding field to help other nurses understand its biological basis and clinical indications. Targeted at oncology nurses, the text will also be of interest in other specialties using biological agents to treat conditions such as hepatitis, autoimmune diseases, and multiple sclerosis. New to this edition are chapters on the retinoids, vaccines, gene therapy, the management of anorexia as a toxic effect, and patients' perspectives on participation in clinical trials. Other new information includes recent data on the immune system, emerging strategies in molecular medicine, clinical "pearls" or tips that summarize key points, and lists of useful Web sites and other resources. Annotation copyrighted by Book News, Inc., Portland, OR
The Autoimmune Diseases
DOWNLOAD
Author : Noel R. Rose
language : en
Publisher: Academic Press
Release Date : 2006
The Autoimmune Diseases written by Noel R. Rose and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. New to This Edition: * Tissue-specific interventions to arrest or “cure” autoimmune disease * Bone marrow eradication and replacement * Both basic science and clinical medicine is covered * Boxed points to emphasize key features of each chapter
Biologics In Rheumatology
DOWNLOAD
Author : Coziana Ciurtin
language : en
Publisher:
Release Date : 2016
Biologics In Rheumatology written by Coziana Ciurtin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with HEALTH & FITNESS categories.
Significant progress has been acquired in the treatment of rheumatic conditions with the introduction of biologic therapies, which has enabled better control of disease activity and improved patients' long-term outcome. Apart from several biologic treatments already licensed for use in autoimmune rheumatic conditions, numerous other agents are currently under investigation. This rapid expansion of the therapeutic armamentarium requires a critical analysis of individual biologic options and their clinical indications, in order to facilitate the optimal use of these new therapies. The authors felt that a comprehensive book revisiting all the evidence available regarding the efficacy, cost-effectiveness and health implications of the use of biologics in rheumatology was needed in order to integrate the clinical, ethical and socio-economic aspects related to their use. This book is aimed at specialist doctors, trainees, nurses and health professionals working in the field of rheumatology. It critically appraises the level of evidence behind the use of biologic agents in diverse autoimmune diseases, comprising separate chapters which focus on rheumatoid arthritis, systemic lupus erythematosus, myositis, systemic sclerosis, Sjogren's syndrome, seronegative spondyloarthropathies, psoriatic arthritis and psoriasis, small, medium and large vessel vasculitis, osteoporosis, and interstitial lung disease associated with rheumatic conditions. In addition, the book explores aspects related to the use of biologic agents, such as ethical considerations of consenting patients to take part in clinical trials with biologics, and adolescent and adult rheumatology nurse perspectives related to patients' benefits of biologic therapies. Particular interest is given to the use of biologics during pregnancy and assessment of their infectious risks. A separate chapter explores the off-target benefits associated with the use of anti-TNF therapies. Several chapters include data about cost-effectiveness, and national and international guidelines for the use of biologic agents in different rheumatic conditions.
Handbook Of Biologics For Rheumatological Disorders
DOWNLOAD
Author : Neeraj Jain
language : en
Publisher:
Release Date : 2022
Handbook Of Biologics For Rheumatological Disorders written by Neeraj Jain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Biologics have revolutionized the treatment of autoimmune diseases due to their efficacy, speed of onset, and tolerability. The development of new agents and expanded use of existing agents continues to be a highly active area of investigation among rheumatic diseases, with a multitude of innovative therapeutic strategies in various stages of development. Although the story of treatments continues rapidly, therapeutic research in some conditions is hindered by the rarity of the disease, variation in phenotype, and concerns about toxicity. This fast-paced development of therapeutics,necessitates immediate evaluation of individual biologic agents and their best use in the new treatment regimens. This book provides an inclusive approach with the existing evidence concerning effectiveness and implications on the usage of biologics in treating various rheumatologic disorders. It also covers the evidence behind the rational use of these agents in varied autoimmune diseases. This manual also offers a complete overview of the existing & futuristic biologic treatments, and draws recommendations on how to standardize the most suitable regimen for a specific patient in the context of current guidelines. The handbook of Biologics in Rheumatology serves as a present and concise compendium to the modern therapeutic developments in the field. This book is likely to benefit clinicians, residents, fellow and other healthcare workers dealing with rheumatological disorders, and also hard-core Rheumatologists, who are looking for a quick recap of Biologics of their interest.