Biomaterials Effect On The Bone Microenvironment

DOWNLOAD
FREE 30 Days

Download Biomaterials Effect On The Bone Microenvironment PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Biomaterials Effect On The Bone Microenvironment book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Biomaterials Effect On The Bone Microenvironment

DOWNLOAD
FREE 30 Days

Author : Jiacan Su
language : en
Publisher: John Wiley & Sons
Release Date : 2023-03-20

Biomaterials Effect On The Bone Microenvironment written by Jiacan Su and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-20 with Technology & Engineering categories.

Biomaterials Effect on the Bone Microenvironment Practical resource on clinical bone regeneration from a variety of related interdisciplinary researchers Biomaterials Effect on the Bone Microenvironment focuses on the structure-activity relationship between bone biomaterials and microenvironment regulation, presenting a systematic exposition from all aspects of biomaterials regulated microenvironment in bone regeneration and covering design strategies, applications, and mechanisms of biomaterials that regulate bone microenvironment, along with the methods for manufacturing biomaterials and their clinical translation. The subject’s potential challenges and future development direction are discussed, and the design and initiative principle of tailored biomaterials with various features, including bioactive components and physicochemical property, are elucidated in depth. Numerous biomaterials, including natural and synthetic, are summarized and compared. Their advantages and features are also evaluated, particularly in bone microenvironmental regulation and bone generation. Moreover, the stimulation mechanism of the microenvironment to bone generation is discussed in detail, including mechanical-support effect, redox effect, pro-angiogenesis effect, inflammatory immune effect, and anti-aging effect. Biomaterials Effect on the Bone Microenvironment provides further coverage of sample topics such as: Role of bone microenvironment and its associated biomaterials in modulation bone diseases, reviewing the biomaterials used to regulate bone microenvironment Relationship between biological factors of various materials and physiological functions in bone microenvironment Application of the third generation of biomaterials, which would regenerate the bone to regulate bone microenvironment Emerging biological material manufacturing technology and mechanisms of novel biomaterial modulating microenvironment for bone regeneration Future outlook of bone tissue engineering along with the general process of bone remodeling and regeneration With comprehensive coverage of one of the most promising and valuable candidates for clinical bone regeneration, Biomaterials Effect on the Bone Microenvironment is an ideal resource for materials scientists, biotechnologists, biochemists, bioengineers, orthopedists, and clinical chemists who want to stay on the cutting edge of this rapidly evolving field.

Detection Of Biomaterial In Vivo Microenvironment Ph E Ph And Its Effect On Bone Defect Regeneration Under Unbalanced Bone Remodling Condition

DOWNLOAD
FREE 30 Days

Author : Wenlong Liu
language : en
Publisher:
Release Date : 2017-01-26

Detection Of Biomaterial In Vivo Microenvironment Ph E Ph And Its Effect On Bone Defect Regeneration Under Unbalanced Bone Remodling Condition written by Wenlong Liu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with categories.

This dissertation, "Detection of Biomaterial in Vivo Microenvironment PH (μe-pH) and Its Effect on Bone Defect Regeneration Under Unbalanced Bone Remodling Condition" by Wenlong, Liu, 刘文龙, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: In scenario of osteoporotic fracture, significantly higher activity of osteoclasts than osteoblasts may lead to continuous loss of bone in fracture/defect site. The impaired bone regeneration efficiency is the major barrier that influences endosseous implants to get a better performance, and this substantially increases the risk of a second fracture, non-union and aseptic implant loosening. Currently, there are no clinically approved biomaterials specifically tailored for applications in osteoporotic bones, and it is a challenging topic for material scientists to design proper orthopaedic biomaterials with biological functions for osteoporotic patients. The key issue for developing such biomaterials is to re-establish normal bone regeneration at the fracture site. According to the literatures, acid-base equilibrium is one of the most important factors that influence behaviours of bone cells. Therefore, microenvironment pH (μe-pH), which is influenced by implants biodegradation, may play a crucial role in guiding the localized bone regeneration. We then propose to reconstruct the regeneration balance by controlling the μe-pH through the application of biodegradable materials. The aims of this study include: 1. Establish a method for in vivo μe-pH detection; 2. Evaluate the effect of μe-pH on early-stage bone regeneration process; 3. Reveal the mechanisms by examining osteoclasts behavior in response to the change of μe-pH. The measurement of in vivo μe-pH was realized by using the pH microelectrode. Alkaline biodegradable materials generated an in vivo μe-pH which was higher than the normal physiological value, in particular, at the initial stage. The preliminary results indicated that osteoclasts may play important roles in the early-stage of defect healing process. Therefore, in order to further study the osteoclasts behaviors in response to the elevated μe-pH in a bone marrow microenvironment, a boneimplant interaction mouse model and a borosilicate glass system (with μe-pH gradient) with same type of ions and similar composition were developed. Based on our in vitro data, osteoclasts differentiation and pit-formation activity were significantly suppressed when RANKL-stimulated RAW264.7 cells were cultured in different glasses extracts which were adjusted to higher pH conditions (pH 7.59-8.02). Furthermore, the abnormal osteoclastogenesis potential of bone marrow cells in mouse after hindlimb unloading treatment could also be balanced by the elevated culture media pH (pH 7.62-7.84). In vivo, significantly suppressed osteoclasts activity together with a thicker new bone on materials surface were observed for glasses with higher e-pHs. Further assessments by using RT-PCR and immunostaining indicated that the decreased activity of matrix-degrading proteases (e.g. cathepsin K) may be one of the reasons for the suppressed osteoclasts activity under higher μe-pH conditions. In conclusion, the impaired regeneration process under osteoporotic or immobilized conditions may be ameliorated by adjusting the materials to generate a weakly-alkaline microenvironment. And the e-pH is an important and accessible factor which should be taken into consideration in the development of orthopaedic biomaterials, in particular for repair of osteoporotic bone fracture /defect. Subjects:

Detection Of Biomaterial In Vivo Microenvironment Ph E Ph And Its Effect On Bone Defect Regeneration Under Unbalanced Bone Remodling Condition

DOWNLOAD
FREE 30 Days

Author : Wenlong Liu
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26

Detection Of Biomaterial In Vivo Microenvironment Ph E Ph And Its Effect On Bone Defect Regeneration Under Unbalanced Bone Remodling Condition written by Wenlong Liu and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Biomedical materials categories.

This dissertation, "Detection of Biomaterial in Vivo Microenvironment PH (μe-pH) and Its Effect on Bone Defect Regeneration Under Unbalanced Bone Remodling Condition" by Wenlong, Liu, 刘文龙, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: In scenario of osteoporotic fracture, significantly higher activity of osteoclasts than osteoblasts may lead to continuous loss of bone in fracture/defect site. The impaired bone regeneration efficiency is the major barrier that influences endosseous implants to get a better performance, and this substantially increases the risk of a second fracture, non-union and aseptic implant loosening. Currently, there are no clinically approved biomaterials specifically tailored for applications in osteoporotic bones, and it is a challenging topic for material scientists to design proper orthopaedic biomaterials with biological functions for osteoporotic patients. The key issue for developing such biomaterials is to re-establish normal bone regeneration at the fracture site. According to the literatures, acid-base equilibrium is one of the most important factors that influence behaviours of bone cells. Therefore, microenvironment pH (μe-pH), which is influenced by implants biodegradation, may play a crucial role in guiding the localized bone regeneration. We then propose to reconstruct the regeneration balance by controlling the μe-pH through the application of biodegradable materials. The aims of this study include: 1. Establish a method for in vivo μe-pH detection; 2. Evaluate the effect of μe-pH on early-stage bone regeneration process; 3. Reveal the mechanisms by examining osteoclasts behavior in response to the change of μe-pH. The measurement of in vivo μe-pH was realized by using the pH microelectrode. Alkaline biodegradable materials generated an in vivo μe-pH which was higher than the normal physiological value, in particular, at the initial stage. The preliminary results indicated that osteoclasts may play important roles in the early-stage of defect healing process. Therefore, in order to further study the osteoclasts behaviors in response to the elevated μe-pH in a bone marrow microenvironment, a boneimplant interaction mouse model and a borosilicate glass system (with μe-pH gradient) with same type of ions and similar composition were developed. Based on our in vitro data, osteoclasts differentiation and pit-formation activity were significantly suppressed when RANKL-stimulated RAW264.7 cells were cultured in different glasses extracts which were adjusted to higher pH conditions (pH 7.59-8.02). Furthermore, the abnormal osteoclastogenesis potential of bone marrow cells in mouse after hindlimb unloading treatment could also be balanced by the elevated culture media pH (pH 7.62-7.84). In vivo, significantly suppressed osteoclasts activity together with a thicker new bone on materials surface were observed for glasses with higher e-pHs. Further assessments by using RT-PCR and immunostaining indicated that the decreased activity of matrix-degrading proteases (e.g. cathepsin K) may be one of the reasons for the suppressed osteoclasts activity under higher μe-pH conditions. In conclusion, the impaired regeneration process under osteoporotic or immobilized conditions may be ameliorated by adjusting the materials to generate a weakly-alkaline microenvironment. And the e-pH is an important and accessible factor which should be taken into consideration in the development of orthopaedic biomaterials, in particular for repair of osteoporotic bone fracture /defect. Subjects:

Bioactive Materials For Bone Regeneration

DOWNLOAD
FREE 30 Days

Author : Jiang Chang
language : en
Publisher: Academic Press
Release Date : 2020-02-28

Bioactive Materials For Bone Regeneration written by Jiang Chang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Technology & Engineering categories.

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments

Cells Biomaterials And Biophysical Stimuli For Bone Cartilage And Muscle Regeneration Volume Ii

DOWNLOAD
FREE 30 Days

Author : Lorenzo Fassina
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-28

Cells Biomaterials And Biophysical Stimuli For Bone Cartilage And Muscle Regeneration Volume Ii written by Lorenzo Fassina and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-28 with Technology & Engineering categories.

This Research Topic is Volume II of the article collection, Cells, Biomaterials, and Biophysical Stimuli for Bone, Cartilage, and Muscle Regeneration Over the last few years, a variety of tissue engineering strategies have been developed to improve the regeneration of bone, cartilage, and skeletal muscle. Numerous studies have proven that physical factors (external mechanical forces, and biomaterials’ features), as well as biochemical factors, may induce cells to reprogram their functions and dynamically adapt to the cellular microenvironment conditions. The advances in understanding the role of biophysical cues in the stem cells microenvironment point out the importance of their application in biomedicine and biotechnology to drive and modulate cell behavior for therapeutic purposes. In this context, many efforts are dedicated to design different strategies to engineer the physical aspects of the natural cellular microenvironment. The development of these technologies may be useful for identifying and studying the physical factors and help to clarify their downstream mechanisms to control cell behavior. This Research Topic will promote an overview of recent advances and cutting-edge approaches based on primary cells, stem cells, extracellular vesicles (EVs), biomaterial scaffolds, bioreactors, biophysical stimuli (e.g., mechanical forces, electromagnetic waves), and biochemical cues. All research involving one or more of the aforementioned cells and methods is welcome to elucidate new basic-research findings (e.g., molecular insights, biochemical pathways toward regeneration) and possible new clinical strategies (e.g., bioreactors for cell factories). An interdisciplinary design (e.g., biology/biochemistry plus bioengineering) is very welcome.

Developments And Applications Of Calcium Phosphate Bone Cements

DOWNLOAD
FREE 30 Days

Author : Changsheng Liu
language : en
Publisher: Springer
Release Date : 2017-10-20

Developments And Applications Of Calcium Phosphate Bone Cements written by Changsheng Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-20 with Technology & Engineering categories.

This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.

Bone Repair Biomaterials

DOWNLOAD
FREE 30 Days

Author : Kendell Pawelec
language : en
Publisher: Woodhead Publishing
Release Date : 2018-11-29

Bone Repair Biomaterials written by Kendell Pawelec and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-29 with Technology & Engineering categories.

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Smart Biomaterials

DOWNLOAD
FREE 30 Days

Author : Mitsuhiro Ebara
language : en
Publisher: Springer
Release Date : 2014-05-28

Smart Biomaterials written by Mitsuhiro Ebara and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-28 with Technology & Engineering categories.

This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.

Bone Tissue Engineering

DOWNLOAD
FREE 30 Days

Author : Jeffrey O. Hollinger
language : en
Publisher: CRC Press
Release Date : 2004-10-14

Bone Tissue Engineering written by Jeffrey O. Hollinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-14 with Medical categories.

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

In Situ Tissue Regeneration

DOWNLOAD
FREE 30 Days

Author : Sang Jin Lee
language : en
Publisher: Academic Press
Release Date : 2016-07-17

In Situ Tissue Regeneration written by Sang Jin Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-17 with Medical categories.

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry