Bioreaction Engineering Bioprocess Monitoring
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Bioreaction Engineering Fundamentals Thermodynamics Formal Kinetics Idealized Reactor Types And Operation Modes
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Author : Karl Schügerl
language : en
Publisher: Wiley
Release Date : 1987-10-27
Bioreaction Engineering Fundamentals Thermodynamics Formal Kinetics Idealized Reactor Types And Operation Modes written by Karl Schügerl and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-10-27 with Technology & Engineering categories.
Bioreaction Engineering Reactions Involving Microorganisms and Cells Volume 1 Fundamentals, Thermodynamics, Formal kinetics, Idealized reactor types and Operation modes Karl Schügerl, Professor of Technical Chemistry, Institut für Technische Chemie, Universität Hannover, West Germany This book is designed to provide a basic introduction to the principles of bioreactors, their operating parameters, and their dynamic behaviour under different conditions. The following topics are covered: Introduction Principles Modus operandi of bioreactors Idealized types Formal kinetics of cell growth and product formation in idealized reactors Operation modes in stirred reactors The book will be valuable to both process and control engineers in the fermentation industry and to researchers and lecturers in biotechnology departments of universities.
Bioreaction Engineering Bioprocess Monitoring
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Author : Karl Schügerl
language : en
Publisher: John Wiley & Sons
Release Date : 1997-04-03
Bioreaction Engineering Bioprocess Monitoring written by Karl Schügerl and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-03 with Science categories.
Volume 3 of Bioreaction Engineering covers the general principles and techniques of bioprocess monitoring and their application for various bioprocesses. Methods based on the author's long standing experience working with various bioprocesses are applied within the book. In particular, the cultivation of Baker's yeast; production of fusion protein with recombinant E. Coli, alkaline serine protease production with Bacillus licheniformis; production of penicillin V with Penicillin chrysogenum; Cephalosporin C with Acremonium chrysogenum and tetracycline with Streptomyces aureofaciens are considered. This book deals with the monitoring of batch and perfusion cultivations of animal cells and production of monoclonal antibodies with hybridoma cells, Antithrombin III with BHK and CHO cells and ß -galactosidase with insect cells. The topics covered include: Bioprocess monitoring techniques Cultivation of Saccharomyces cerevisiae Production of Fusion Protein with Recombinanat E. coli Alkaline Protease Production with Bacillus licheniformis Antibiotica Production by Fungi and Streptomycetes Continuous Production of Primary Metabolites with Suspended and Immobilized Microorganisms Cultivation of Animal Cells and Production of Proteins Anaerobic Waste Water Treatment Fast Process Monitoring Techniques Image Analysis of Cells and Cell Aggregates Evaluation of Experimental Data to the Calculation of Metabolite Flux in Microorganisms and Animal Cells Signal Evaluation, Automation and Expert Systems for Process Monitoring Bioprocess Monitoring is invaluable for process engineers, analytical chemists and researchers in biotechnological, pharmaceutical, environmnental and chemical industries.
Control In Bioprocessing
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Author : Pablo A. López Pérez
language : en
Publisher: John Wiley & Sons
Release Date : 2020-03-10
Control In Bioprocessing written by Pablo A. López Pérez and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-10 with Technology & Engineering categories.
Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.
Bioreaction Engineering Principles
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Author : Jens Nielsen
language : en
Publisher: Springer
Release Date : 2012-12-06
Bioreaction Engineering Principles written by Jens Nielsen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.
This is the second edition of the text "Bioreaction Engineering Principles" by Jens Nielsen and John Villadsen, originally published in 1994 by Plenum Press (now part of Kluwer). Time runs fast in Biotechnology, and when Kluwer Plenum stopped reprinting the first edition and asked us to make a second, revised edition we happily accepted. A text on bioreactions written in the early 1990's will not reflect the enormous development of experimental as well as theoretical aspects of cellular reactions during the past decade. In the preface to the first edition we admitted to be newcomers in the field. One of us (JV) has had 10 more years of job training in biotechnology, and the younger author (IN) has now received international recognition for his work with the hottest topics of "modem" biotechnology. Furthermore we are happy to have induced Gunnar Liden, professor of chemical reaction engineering at our sister university in Lund, Sweden to join us as co-author of the second edition. His contribution, especially on the chemical engineering aspects of "real" bioreactors has been of the greatest value. Chapter 8 of the present edition is largely unchanged from the first edition. We wish to thank professor Martin Hjortso from LSU for his substantial help with this chapter.
Bioreaction Engineering Principles
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Author : Jens Nielsen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Bioreaction Engineering Principles written by Jens Nielsen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
Integrating recent research on the physiology and modelling of bioreactions and bioreactors, the authors present a comprehensive, unified introduction to the principles and practices of the field. The work features nearly 100 detailed design examples and problems, many of which are suitable for hands-on demonstrations on a personal computer or for expanded research. The text will serve as a highly instructive guide for students in bioengineering and biotechnology, as well as biochemical, chemical, and environmental engineering.
Bioreaction Engineering
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Author : K. Schügerl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Bioreaction Engineering written by K. Schügerl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.
Advances In Bioprocess Engineering And Technology
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Author : Doraiswami Ramkrishna
language : en
Publisher: Springer Nature
Release Date : 2020-09-29
Advances In Bioprocess Engineering And Technology written by Doraiswami Ramkrishna and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-29 with Technology & Engineering categories.
This book presents the select peer-reviewed proceedings of the International Conference on Advances in Bioprocess Engineering and Technology (ICABET 2020). The book covers all aspects of bioprocesses, especially related to fermentation technology, food technology, environmental biotechnology, and sustainable energy. Along with this primary theme, the focus is on recent advances in bioprocessing research such as biosensors, micro-reactors, novel separation techniques, bioprocess control, bio-safety, advanced techniques for waste to wealth generation, and nanobiotechnology. This contents are divided according to the major themes of the conference: (i) Fermentation Technology and Bioreactor, (ii) Food Pharmaceuticals and Health care, (iii) Environment and Agriculture, and (iv) Sustainable Energy. This book is intended to help students, researchers, and industry professionals acquire knowledge on innovative technologies and recent advancements in the field of bioprocess engineering and technology.
Measurement Monitoring Modelling And Control Of Bioprocesses
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Author : Carl-Fredrik Mandenius
language : en
Publisher: Springer
Release Date : 2014-07-08
Measurement Monitoring Modelling And Control Of Bioprocesses written by Carl-Fredrik Mandenius and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, by Bernhard Sonnleitner Automatic Control of Bioprocesses, by Marc Stanke, Bernd Hitzmann An Advanced Monitoring Platform for Rational Design of Recombinant Processes, by G. Striedner, K. Bayer Modelling Approaches for Bio-Manufacturing Operations, by Sunil Chhatre Extreme Scale-Down Approaches for Rapid Chromatography Column Design and Scale-Up During Bioprocess Development, by Sunil Chhatre Applying Mechanistic Models in Bioprocess Development, by Rita Lencastre Fernandes, Vijaya Krishna Bodla, Magnus Carlquist, Anna-Lena Heins, Anna Eliasson Lantz, Gürkan Sin and Krist V. Gernaey Multivariate Data Analysis for Advancing the Interpretation of Bioprocess Measurement and Monitoring Data, by Jarka Glassey Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks, by Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira Knowledge Management and Process Monitoring of Pharmaceutical Processes in the Quality by Design Paradigm, by Anurag S Rathore, Anshuman Bansal, Jaspinder Hans The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses, by Ian Marison, Siobhán Hennessy, Róisín Foley, Moira Schuler, Senthilkumar Sivaprakasam, Brian Freeland
Development Of Soft Sensors For Monitoring And Control Of Bioprocesses
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Author : Robert Gustavsson
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-10-31
Development Of Soft Sensors For Monitoring And Control Of Bioprocesses written by Robert Gustavsson and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-31 with categories.
In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online sensor signals can be used as inputs to mathematical models to derive new valuable process information. This information could then be used for better monitoring and control of the bioprocess. The aim of the present thesis has been to develop soft sensor solutions for upstream bioprocessing and demonstrate their usefulness in improving robustness and increase the batch-to-batch reproducibility in bioprocesses. The thesis reviews the potential and possibilities with soft sensors for use in production of bio-therapeutics to realize FDA´s process analytical technology (PAT) initiative. Modelling and hardware sensor alternatives which could be used in a soft sensor setup are described and critically analyzed. Different soft sensor approaches to control glucose feeding in fed-batch cultures of Escherichia coli are described. Measurements of metabolic fluxes and specific carbon dioxide production was used as control parameters to increase product yield and decrease the variability of produced recombinant proteins. Metabolic heat signals were used in uninduced cultures to estimate and control the specific growth rate at a desired level and thereby also estimate the biomass concentration online. The introduction of sequential filtering of the signal enabled this method to be used in a down-scaled system. The risk and high impact of contaminations in cell cultures are also described. An in situ microscope (ISM) was used as an online tool to estimate cell concentration and also to determine cell diameter size which enabled the detection of contaminant cells at an early stage. The work presented in this thesis supports the idea that soft sensors can be a useful tool in the strive towards robust and reliable bioprocesses, to ensure high product quality and increased economic profit.
Recent Advances In Bioprocess Engineering And Bioreactor Design
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Author : Swasti Dhagat
language : en
Publisher: Springer Nature
Release Date :
Recent Advances In Bioprocess Engineering And Bioreactor Design written by Swasti Dhagat and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.