Bioreactor System Design
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Bioreactor System Design
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Author : Juan A. Asenjo
language : en
Publisher: CRC Press
Release Date : 1994-11-17
Bioreactor System Design written by Juan A. Asenjo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-17 with Science categories.
Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.
Bioreactors
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Author : Carl-Fredrik Mandenius
language : en
Publisher: John Wiley & Sons
Release Date : 2016-02-16
Bioreactors written by Carl-Fredrik Mandenius and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-16 with Science categories.
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
Bioreactors For Tissue Engineering
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Author : Julian Chaudhuri
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-16
Bioreactors For Tissue Engineering written by Julian Chaudhuri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-16 with Medical categories.
For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.
Bioreactor Systems For Tissue Engineering
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Author : Cornelia Kasper
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-02-03
Bioreactor Systems For Tissue Engineering written by Cornelia Kasper and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-03 with Science categories.
The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.
Bioreactor Design Fundamentals
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Author : Norton G. McDuffie
language : en
Publisher: Butterworth-Heinemann
Release Date : 2013-10-22
Bioreactor Design Fundamentals written by Norton G. McDuffie and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Technology & Engineering categories.
Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs). This book is a valuable resource for biochemical engineers and industrial microbiologists.
Design Of A Single Well Bioreactor Incubator System With Sterile Nutrient Media Supply
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Author : Manuel Kohlmann
language : en
Publisher: Diplomica Verlag
Release Date : 2011-03
Design Of A Single Well Bioreactor Incubator System With Sterile Nutrient Media Supply written by Manuel Kohlmann and has been published by Diplomica Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03 with Technology & Engineering categories.
Perfused bioreactors have been developed with different designs and with various cell lines such as fibroblasts, osteoblasts and C2C12 myoblasts. All these current systems are custom made and mostly capable for only one cell type. Small seeding spaces and chambers inhibit longer cell studies and the observation of cell interaction. This study presents an advanced perfusion bioreactor which allows cell observation for longer than 5 days on an area of 2.8cm2 with a volume of 17ml. Initial experiments investigated homogeneity of the heat distribution, which is precisely controlled and stable over the length of the experiment. The addition of perfusion to the system results in the manual feeding process with modified F12 nutrient media being unnecessary. The perfusion and perfusion rate are user controllable up to 8ml/h. Different inlets allow cell seeding, cell feeding and chemical stimulation. Since the metabolism by-products are diluted and removed by the flow of the perfused system, no inhibited growth occurs and the pH-value will maintain constant at 7.4 which removes the need for balancing the CO2 environment. Fully enclosed and sealed assemblies with a controlled hot plate can be used outside of the incubator and incorporated into the stage of a microscope to track and monitor cell growth. The bioreactor chamber consists of three parts of transparent annealed cast Acrylic plus sealing material. Acrylic is chosen since it is machinable by laser cutting, which is a fast and easy method of manufacture. Due to the annealing process sterilizing by ethanol is possible. Heat distribution analysis was made with an IR-camera. And the pH was tested by indicator paper. The flow rate was set at 3.3ml/h. Computer simulations for flow and heat distribution and standard tests with cell cultures showed that a round bioreactor chamber design has advantages due to more uniform conditions. To track the cells during their distribution and over their whole life cycle, a completely transparent system is being developed. It includes an Indium Tin Oxide (ITO) coated glass plate, which can be used as a hot plate with precise controlled heating properties to heat the whole chamber.
Principles Of Bioreactor Design
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Author : Binoy Ranjan Maiti
language : en
Publisher:
Release Date : 2018
Principles Of Bioreactor Design written by Binoy Ranjan Maiti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Bioreactors categories.
Fast Reactor System Design
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Author : Naoto Kasahara
language : en
Publisher: Springer
Release Date : 2017-03-01
Fast Reactor System Design written by Naoto Kasahara and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-01 with Technology & Engineering categories.
This book describes the fast reactor (FR), a type of new reactor for nuclear plants, currently under research and development. The book targets young researchers and engineers who will be charged with commercializing this new type of reactor to lead to the development of new components and systems for improved plant reliability and economy. This volume also helps readers to understand the methods of integrating the power plant in its entirety, from the reactor core to all of the various systems and components, and teaches the way of thinking that forms the background of these methods. This background includes the various organizational and management issues that are encountered as projects move forward and will be explored in great detail based on actual design and construction experience with Japan’s prototype FR, Monju.
Multiphase Bioreactor Design
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Author : Joaquim M.S. Cabral
language : en
Publisher: CRC Press
Release Date : 2001-09-20
Multiphase Bioreactor Design written by Joaquim M.S. Cabral and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-20 with Science categories.
Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and animal cells and higher organisms. A reference text for postgraduate students and researchers in biochemical engineering and bioreactor design, Multiphase Bioreactor Design describes the
Basic Bioreactor Design
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Author : Klaas van't Riet
language : en
Publisher: CRC Press
Release Date : 1991-01-07
Basic Bioreactor Design written by Klaas van't Riet and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-07 with Medical categories.
Based on a graduate course in biochemical engineering, provides the basic knowledge needed for the efficient design of bioreactors and the relevant principles and data for practical process engineering, with an emphasis on enzyme reactors and aerated reactors for microorganisms. Includes exercises,