Biosimulation In Drug Development
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Biosimulation In Drug Development
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Author : Martin Bertau
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Biosimulation In Drug Development written by Martin Bertau and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Medical categories.
This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.
Biosimulation In Drug Development
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Author : Martin Bertau
language : en
Publisher: John Wiley & Sons
Release Date : 2007-11-28
Biosimulation In Drug Development written by Martin Bertau and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-28 with Science categories.
This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.
Biosimulation In Biomedical Research Health Care And Drug Development
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Author : Erik Mosekilde
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-01
Biosimulation In Biomedical Research Health Care And Drug Development written by Erik Mosekilde and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-01 with Medical categories.
Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.
Systems Biology In Drug Discovery And Development
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Author : Daniel L. Young
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-23
Systems Biology In Drug Discovery And Development written by Daniel L. Young and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-23 with Medical categories.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
Global New Drug Development
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Author : Jan A. Rosier
language : en
Publisher: John Wiley & Sons
Release Date : 2014-07-03
Global New Drug Development written by Jan A. Rosier and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-03 with Medical categories.
The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service providers, in constant dialogue with regulatory authorities, payers, academic experts, clinicians and patient organizations. Within the different phases of the drug life cycle, drug development is by far the most crucial part for the initial and continued success of a drug on the market. This book offers an introduction to the field of drug development with a clear overview of the different processes that lead to a successful new medicine and of the regulatory pathways that are used to launch a new drug that are both safe and efficacious. "This is the most comprehensive and detailed book on drug development I have ever read and I feel that it is likely to become a staple of drug development courses, such as those taught at Masters Level in my own University.... I think in the light of increasing integration of company and academic approaches to drug development both sides can read this book... (and, therefore)... this book could not be more timely." —Professor Mike Coleman, University of Aston, UK ( from his review of the final manuscript)
Drug Efficacy Safety And Biologics Discovery
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Author : Sean Ekins
language : en
Publisher: John Wiley & Sons
Release Date : 2009-01-28
Drug Efficacy Safety And Biologics Discovery written by Sean Ekins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-28 with Medical categories.
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
The Singularity Is Nearer
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Author : Ray Kurzweil
language : en
Publisher: Random House
Release Date : 2024-06-27
The Singularity Is Nearer written by Ray Kurzweil and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-27 with Computers categories.
THE INTERNATIONAL BESTSELLER The legendary oracle of technological change explains how AI will transform our species beyond recognition. ‘The best person I know at predicting the future of AI’ BILL GATES 'Essential reading to understand our exponential times' MUSTAFA SULEYMAN 'Fascinating . . . raises the most profound philosophical questions' YUVAL NOAH HARARI By the end of this decade, AI will exceed human levels of intelligence. During the 2030s, it will become ‘superintelligent’, vastly outstripping our capabilities and enabling dramatic interventions in our bodies. By 2045, we will be able to connect our brains directly with AI, enhancing our intelligence a millionfold and expanding our consciousness in ways we can barely imagine. This is the Singularity. Ray Kurzweil is one of the greatest inventors of our time with over 60 years’ experience in the field of Artificial Intelligence, whose long-range predictions about the rise of the internet, AI and bioengineering have all borne out. In this visionary, fundamentally optimistic book, Kurzweil explains how the Singularity will occur, explores what it will mean to live free from the limits of biology and argues that we can and will transform life on Earth profoundly for the better. 'The greatest oracle of our digital age' PETER H. DIAMANDIS, founder of XPRIZE 'Curious about the future? Read this book' VINT CERF, Chief Internet Evangelist, Google
Antibody Drug Conjugates
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Author : Kenneth J. Olivier, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2016-11-14
Antibody Drug Conjugates written by Kenneth J. Olivier, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Medical categories.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Mathematical Methods And Models In Biomedicine
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Author : Urszula Ledzewicz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-20
Mathematical Methods And Models In Biomedicine written by Urszula Ledzewicz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-20 with Mathematics categories.
Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phenomena in various temporal and spatial settings. This book illustrates the breadth and depth of research opportunities that exist in the general field of mathematical biomedicine by highlighting some of the fascinating interactions that continue to develop between the mathematical and biomedical sciences. It consists of five parts that can be read independently, but are arranged to give the reader a broader picture of specific research topics and the mathematical tools that are being applied in its modeling and analysis. The main areas covered include immune system modeling, blood vessel dynamics, cancer modeling and treatment, and epidemiology. The chapters address topics that are at the forefront of current biomedical research such as cancer stem cells, immunodominance and viral epitopes, aggressive forms of brain cancer, or gene therapy. The presentations highlight how mathematical modeling can enhance biomedical understanding and will be of interest to both the mathematical and the biomedical communities including researchers already working in the field as well as those who might consider entering it. Much of the material is presented in a way that gives graduate students and young researchers a starting point for their own work.